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  • Malmqvist, KarinKarolinska Institutet,Division of Internal Medicine, Karolinska Institutet, Danderyd Hospital, Danderyd, Sweden (author)

Regression of left ventricular hypertrophy in human hypertension with irbesartan

  • Article/chapterEnglish2001

Publisher, publication year, extent ...

  • Ovid Technologies (Wolters Kluwer Health),2001
  • printrdacarrier

Numbers

  • LIBRIS-ID:oai:DiVA.org:uu-73124
  • https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-73124URI
  • http://kipublications.ki.se/Default.aspx?queryparsed=id:1934506URI
  • https://doi.org/10.1097/00004872-200106000-00023DOI
  • https://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-47354URI

Supplementary language notes

  • Language:English
  • Summary in:English

Part of subdatabase

Classification

  • Subject category:ref swepub-contenttype
  • Subject category:art swepub-publicationtype

Notes

  • BACKGROUND: The Swedish irbesartan left ventricular hypertrophy investigation versus atenolol (SILVHIA). OBJECTIVE: Angiotensin II induces myocardial hypertrophy. We hypothesized that blockade of angiotensin II subtype 1 (AT1) receptors by the AT1-receptor antagonist irbesartan would reduce left ventricular mass (as measured by echocardiography) more than conventional treatment with a beta blocker. DESIGN AND METHODS: This double-blind study randomized 115 hypertensive men and women with left ventricular hypertrophy to receive either irbesartan 150 mg q.d. or atenolol 50 mg q.d. for 48 weeks. If diastolic blood pressure remained above 90 mmHg, doses were doubled, and additional medications (hydrochlorothiazide and felodipine) were prescribed as needed. Echocardiography was performed at weeks 0, 12, 24 and 48. RESULTS: Baseline mean blood pressure was 162/ 104 mmHg, and mean left ventricular mass index was 157 g/m2 for men and 133 g/m2 for women. Systolic and diastolic blood pressure reductions were similar in both treatment groups. Both irbesartan (P < 0.001) and atenolol (P< 0.001) progressively reduced left ventricular mass index, e.g. by 26 and 14 g/m2 (16 and 9%), respectively, at week 48, with a greater reduction in the irbesartan group (P = 0.024). The proportion of patients who attained a normalized left ventricular mass (i.e. < or = 131 g/m2 for men and < or = 100 g/m2 for women) tended to be greater with irbesartan (47 versus 32%, P = 0.108). CONCLUSIONS: Left ventricular mass was reduced more in the irbesartan group than in the atenolol group. These results suggest that blocking the action of angiotensin II at AT1-receptors may be an important mechanism, beyond that of lowering blood pressure, in the regulation of left ventricular mass and geometry in patients with hypertension.

Subject headings and genre

  • Adrenergic beta-Antagonists/adverse effects/therapeutic use
  • Adult
  • Aged
  • Atenolol/adverse effects/therapeutic use
  • Biphenyl Compounds/adverse effects/*therapeutic use
  • Blood Pressure/drug effects
  • Double-Blind Method
  • Female
  • Heart Rate/drug effects
  • Humans
  • Hypertension/complications/*drug therapy/pathology/physiopathology
  • Hypertrophy; Left Ventricular/complications/*drug therapy/pathology/physiopathology
  • Male
  • Middle Aged
  • Receptor; Angiotensin; Type 1
  • Receptors; Angiotensin/*antagonists & inhibitors
  • Research Support; Non-U.S. Gov't
  • Safety
  • Tetrazoles/adverse effects/*therapeutic use
  • Vascular Resistance/drug effects
  • MEDICINE
  • MEDICIN

Added entries (persons, corporate bodies, meetings, titles ...)

  • Kahan, ThomasKarolinska Institutet,Division of Internal Medicine, Karolinska Institutet, Danderyd Hospital, Danderyd, Sweden, Karolinska Institutet Danderyd Hospital, Section of Cardiology, Division of Internal Medicine, S-182 88 Danderyd, Sweden (author)
  • Edner, MagnusKarolinska Institutet,Division of Internal Medicine, Karolinska Institutet, Danderyd Hospital, Danderyd, Sweden (author)
  • Held, ClaesDivision of Internal Medicine, Karolinska Institutet, Danderyd Hospital, Danderyd, Sweden(Swepub:uu)clahe947 (author)
  • Hägg, AndersUppsala universitet,Institutionen för medicinska vetenskaper,Akut- och internmedicin,Hägg, A., Department of Internal Medicine, University Hospital, Uppsala, Sweden (author)
  • Lind, LarsUppsala universitet,Institutionen för medicinska vetenskaper,Akut- och internmedicin,Department of Internal Medicine, University Hospital, Uppsala, Sweden(Swepub:uu)larslind (author)
  • Muller-Brunotte, RichardMüller-Brunotte, R., Division of Internal Medicine, Karolinska Institutet, Danderyd Hospital, Danderyd, Sweden (author)
  • Nyström, FredrikÖstergötlands Läns Landsting,Linköpings universitet,Hälsouniversitetet,Internmedicin,Endokrin- och magtarmmedicinska kliniken US(Swepub:liu)freny92 (author)
  • Öhman, K. Peter (author)
  • Osbakken, Mary D.University of Pennsylvania, Philadelphia, PA, United States (author)
  • Östergern, JanKarolinska Institutet,Östergren, J., Division of Emergency and Cardiovascular Medicine, Karolinska Hospital, Stockholm, Sweden (author)
  • Karolinska InstitutetDivision of Internal Medicine, Karolinska Institutet, Danderyd Hospital, Danderyd, Sweden (creator_code:org_t)

Related titles

  • In:Journal of Hypertension: Ovid Technologies (Wolters Kluwer Health)19:6, s. 1167-11760263-63521473-5598

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