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Oxetane modified, conformationally constrained, antisense oligodeoxyribonucleotides function efficiently as gene silencing molecules.

Opalinska, J B (author)
Kalota, A (author)
Gifford, Lida K (author)
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Lu, Ponzy (author)
Jen, Kuang-Yu (author)
Pradeepkumar, P I (author)
Uppsala universitet,Institutionen för bioorganisk kemi
Barman, J (author)
Uppsala universitet,Institutionen för bioorganisk kemi
Kim, T K (author)
Swider, C R (author)
Chattopadhyaya, J (author)
Uppsala universitet,Institutionen för bioorganisk kemi
Gewirtz, A M (author)
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 (creator_code:org_t)
2004
2004
English.
In: Nucleic Acids Res. - 1362-4962. ; 32:19, s. 5791-9
  • Journal article (other academic/artistic)
Subject headings
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Keyword

Cell Division/drug effects
Comparative Study
Ethers; Cyclic/*chemistry
Gene Silencing
Humans
K562 Cells
Nucleic Acid Conformation
Oligodeoxyribonucleotides; Antisense/*chemistry/metabolism/*pharmacology
Proto-Oncogene Proteins c-myb/genetics/metabolism
RNA; Messenger/metabolism
RNA; Small Interfering/*chemistry/metabolism/*pharmacology
Research Support; Non-U.S. Gov't
Research Support; U.S. Gov't; P.H.S.
Thionucleotides/chemistry

Publication and Content Type

vet (subject category)
art (subject category)

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