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Secretion of granule proteins from eosinophils and neutrophils is increased in asthma

Carlson, Marie (författare)
Uppsala universitet,Institutionen för medicinska vetenskaper
Håkansson, Lena (författare)
Uppsala universitet,Institutionen för medicinska vetenskaper
Peterson, Christer (författare)
Uppsala universitet,Institutionen för medicinska vetenskaper
visa fler...
Stålenheim, Gunnemar (författare)
Uppsala universitet,Institutionen för medicinska vetenskaper
Venge, Per (författare)
Uppsala universitet,Institutionen för medicinska vetenskaper
visa färre...
 (creator_code:org_t)
Elsevier BV, 1991
1991
Engelska.
Ingår i: Journal of Allergy and Clinical Immunology. - : Elsevier BV. - 0091-6749 .- 1097-6825. ; 87:1 Pt 1, s. 27-33
  • Tidskriftsartikel (refereegranskat)
Abstract Ämnesord
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  • The activity of eosinophil and neutrophil granulocytes with respect to secretion of granule proteins was studied in 30 patients with asthma and with varying severity of their disease. Granulocytes were stimulated with serum-opsonized Sephadex particles, and the released amount of eosinophil cationic protein (ECP), eosinophil protein X (EPX), and myeloperoxidase was measured by means of specific radioimmunoassays. Eosinophils from patients with asthma released significantly more (p less than 0.001) ECP and EPX after 20 minutes of incubation than cells from control subjects without asthma. The release of myeloperoxidase from neutrophils was also somewhat higher (p less than 0.03). The serum concentrations of ECP and EPX were also significantly increased (p less than 0.001) in the group with asthma. No significant relationships were found between clinical variables and the secretory activity of either eosinophils or neutrophils. We conclude that eosinophils and, to some extent, neutrophils from subjects with asthma have an increased propensity to release their granule proteins, which we suggest is a consequence of priming of these cells.

Nyckelord

Adult
Aged
Asthma/*metabolism
Blood Proteins/*secretion
Cell Degranulation
Eosinophil Granule Proteins
Eosinophils/*secretion
Female
Humans
Leukocyte Count
Male
Middle Aged
Neutrophils/*secretion
Peroxidase/secretion
Research Support; Non-U.S. Gov't
Ribonucleases
MEDICINE
MEDICIN

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