The genome sequence of Trypanosoma cruzi, etiologic agent of Chagas disease.

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MARC

El-Sayed, Najib M. (author)

The genome sequence of Trypanosoma cruzi, etiologic agent of Chagas disease.

Article/chapterEnglish2005

Publisher, publication year, extent ...

American Association for the Advancement of Science (AAAS),2005
printrdacarrier

Numbers

LIBRIS-ID:oai:DiVA.org:uu-74416
https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-74416URI
https://doi.org/10.1126/science.1112631DOI
http://kipublications.ki.se/Default.aspx?queryparsed=id:1949447URI

Supplementary language notes

Language:English
Summary in:English

Part of subdatabase

SwePubSwePub

Classification

Subject category:ref swepub-contenttype
Subject category:art swepub-publicationtype

Notes

Whole-genome sequencing of the protozoan pathogen Trypanosoma cruzi revealed that the diploid genome contains a predicted 22,570 proteins encoded by genes, of which 12,570 represent allelic pairs. Over 50% of the genome consists of repeated sequences, such as retrotransposons and genes for large families of surface molecules, which include trans-sialidases, mucins, gp63s, and a large novel family (>1300 copies) of mucin-associated surface protein (MASP) genes. Analyses of the T. cruzi, T. brucei, and Leishmania major (Tritryp) genomes imply differences from other eukaryotes in DNA repair and initiation of replication and reflect their unusual mitochondrial DNA. Although the Tritryp lack several classes of signaling molecules, their kinomes contain a large and diverse set of protein kinases and phosphatases; their size and diversity imply previously unknown interactions and regulatory processes, which may be targets for intervention.

Subject headings and genre

NATURVETENSKAP Biologi Genetik hsv//swe
NATURAL SCIENCES Biological Sciences Genetics hsv//eng
Animals
Chagas Disease/drug therapy/parasitology
DNA Repair
DNA Replication
DNA; Mitochondrial/genetics
DNA; Protozoan/genetics
Genes; Protozoan
Genome; Protozoan
Humans
Meiosis
Membrane Proteins/chemistry/genetics/physiology
Multigene Family
Protozoan Proteins/chemistry/*genetics/physiology
Recombination; Genetic
Repetitive Sequences; Nucleic Acid
Research Support; N.I.H.; Extramural
Research Support; Non-U.S. Gov't
Research Support; U.S. Gov't; P.H.S.
Retroelements
Sequence Analysis; DNA
Signal Transduction
Telomere/genetics
Trypanocidal Agents/pharmacology/therapeutic use
Trypanosoma cruzi/chemistry/*genetics/physiology
Genetics
Genetik

Added entries (persons, corporate bodies, meetings, titles ...)

Myler, Peter J (author)
Bartholomeu, Daniella C (author)
Nilsson, DanielKarolinska Institutet (author)
Aggarwal, Gautam (author)
Tran, Anh-NhiKarolinska Institutet (author)
Ghedin, Elodie (author)
Worthey, Elizabeth A (author)
Delcher, Arthur L (author)
Blandin, Gaêlle (author)
Westenberger, Scott J (author)
Caler, Elisabet (author)
Cerqueira, Gustavo C (author)
Branche, Carole (author)
Haas, Brian (author)
Anupama, Atashi (author)
Arner, Erik (author)
Aslund, LenaUppsala universitet,Institutionen för genetik och patologi(Swepub:uu)lenaaslu (author)
Attipoe, Philip (author)
Bontempi, Esteban (author)
Bringaud, Frederic (author)
Burton, Peter (author)
Cadag, Eithon (author)
Campbell, David A (author)
Carrington, Mark (author)
Crabtree, Jonathan (author)
Darban, Hamid (author)
da Silveira, Jose Franco (author)
de Jong, Pieter (author)
Edwards, Kimberly (author)
Englund, Paul T (author)
Fazelina, Gholam (author)
Feldblyum, Tamara (author)
Ferella, MarcelaKarolinska Institutet (author)
Frasch, Alberto Carlos (author)
Gull, Keith (author)
Horn, David (author)
Hou, Lihua (author)
Huang, Yiting (author)
Kindlund, EllenKarolinska Institutet (author)
Klingbeil, Michele (author)
Kluge, Sindy (author)
Koo, Hean (author)
Lacerda, Daniela (author)
Levin, Mariano J (author)
Lorenzi, Hernan (author)
Louie, Tin (author)
Machado, Carlos Renato (author)
McCulloch, Richard (author)
McKenna, Alan (author)
Mizuno, Yumi (author)
Mottram, Jeremy C (author)
Nelson, Siri (author)
Ochaya, StephenKarolinska Institutet (author)
Osoegawa, Kazutoyo (author)
Pai, Grace (author)
Parsons, Marilyn (author)
Pentony, Martin (author)
Pettersson, UlfUppsala universitet,Institutionen för genetik och patologi(Swepub:uu)ulfpette (author)
Pop, Mihai (author)
Ramirez, Jose Luis (author)
Rinta, Joel (author)
Robertson, Laura (author)
Salzberg, Steven L (author)
Sanchez, Daniel O (author)
Seyler, Amber (author)
Sharma, Reuben (author)
Shetty, Jyoti (author)
Simpson, Anjana J (author)
Sisk, Ellen (author)
Tammi, Martti TKarolinska Institutet (author)
Tarleton, Rick (author)
Teixeira, Santuza (author)
Van Aken, Susan (author)
Vogt, Christy (author)
Ward, Pauline N (author)
Wickstead, Bill (author)
Wortman, Jennifer (author)
White, Owen (author)
Fraser, Claire M (author)
Stuart, Kenneth D (author)
Andersson, BjörnKarolinska Institutet (author)
Karolinska InstitutetInstitutionen för genetik och patologi (creator_code:org_t)

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In:Science: American Association for the Advancement of Science (AAAS)309:5733, s. 409-151095-92030036-8075

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By the author/editor: El-Sayed, Najib ...; Myler, Peter J; Bartholomeu, Dan ...; Nilsson, Daniel; Aggarwal, Gautam; Tran, Anh-Nhi; show more...; Ghedin, Elodie; Worthey, Elizabe ...; Delcher, Arthur ...; Blandin, Gaêlle; Westenberger, Sc ...; Caler, Elisabet; Cerqueira, Gusta ...; Branche, Carole; Haas, Brian; Anupama, Atashi; Arner, Erik; Aslund, Lena; Attipoe, Philip; Bontempi, Esteba ...; Bringaud, Freder ...; Burton, Peter; Cadag, Eithon; Campbell, David ...; Carrington, Mark; Crabtree, Jonath ...; Darban, Hamid; da Silveira, Jos ...; de Jong, Pieter; Edwards, Kimberl ...; Englund, Paul T; Fazelina, Gholam; Feldblyum, Tamar ...; Ferella, Marcela; Frasch, Alberto ...; Gull, Keith; Horn, David; Hou, Lihua; Huang, Yiting; Kindlund, Ellen; Klingbeil, Miche ...; Kluge, Sindy; Koo, Hean; Lacerda, Daniela; Levin, Mariano J; Lorenzi, Hernan; Louie, Tin; Machado, Carlos ...; McCulloch, Richa ...; McKenna, Alan; Mizuno, Yumi; Mottram, Jeremy ...; Nelson, Siri; Ochaya, Stephen; Osoegawa, Kazuto ...; Pai, Grace; Parsons, Marilyn; Pentony, Martin; Pettersson, Ulf; Pop, Mihai; Ramirez, Jose Lu ...; Rinta, Joel; Robertson, Laura; Salzberg, Steven ...; Sanchez, Daniel ...; Seyler, Amber; Sharma, Reuben; Shetty, Jyoti; Simpson, Anjana ...; Sisk, Ellen; Tammi, Martti T; Tarleton, Rick; Teixeira, Santuz ...; Van Aken, Susan; Vogt, Christy; Ward, Pauline N; Wickstead, Bill; Wortman, Jennife ...; White, Owen; Fraser, Claire M; Stuart, Kenneth ...; Andersson, Björn; show less...

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NATURAL SCIENCES: NATURAL SCIENCES; and Biological Scien ...; and Genetics

Articles in the publication: Science

By the university: Uppsala University; Karolinska Institutet

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