On the use of liquid chromatography with radio- and ultraviolet absorbance detection coupled to mass spectrometry for improved sensitivity and selectivity in determination of specific radioactivity of radiopharmaceuticaIs

• Pneumatically assisted electrospray mass spectrometry was evaluated as a complementary detection technique to UV absorbance, for determination of specific radioactivity of tracer molecules to be used in positron emission tomography. Tracers labelled with

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liquid chromatography; mass spectrometry; specific radioacitivity; carbon-11; POSITRON EMISSION TOMOGRAPHY; ATMOSPHERIC-PRESSURE; ELECTROSPRAY-IONIZATION; RHESUS-MONKEY; DOPAMINE-RECEPTORS; HUMAN-BRAIN; PET; BINDING; BIODISTRIBUTION; KINETICS

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