Search: onr:"swepub:oai:DiVA.org:uu-93074" >
Microwave-Enhanced ...
Microwave-Enhanced and Metal-Catalyzed Functionalizations of the 4-Aryl-Dihydropyrimidone Template
-
- Wannberg, Johan (author)
- Uppsala universitet,Avdelningen för organisk farmaceutisk kemi
-
Dallinger, Doris (author)
-
Kappe, C. Oliver (author)
-
show more...
-
- Larhed, Mats (author)
- Uppsala universitet,Avdelningen för organisk farmaceutisk kemi
-
show less...
-
(creator_code:org_t)
- 2005
- 2005
- English.
-
In: Journal of combinatorial chemistry. - 1520-4766 .- 1520-4774. ; 7:4, s. 574-583
- Related links:
-
http://www.ncbi.nlm....
-
show more...
-
https://urn.kb.se/re...
-
show less...
Abstract
Subject headings
Close
- Progress in organometallic catalysis and recent advancements in the development of carbonylative reaction protocols without direct use of carbon monoxide have been utilized for efficient functionalizations of 4-aryl-dihydropyrimidone structures. The use of modern microwave technology enabled both high reaction rates and convenient handling. Examples of palladium-catalyzed cross-couplings, Heck reactions, amino- and alkoxycarbonylations, and direct N-amidations of 4-(bromophenyl)-dihydropyrimidones were performed. Further, the first N3-arylations of the dihydropyrimidone ring system were successfully completed using the copper-catalyzed Goldberg reaction. Altogether, these protocols provide new tools for rapid generation of novel and diverse dihydropyrimidone derivatives.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Läkemedelskemi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Medicinal Chemistry (hsv//eng)
Publication and Content Type
- ref (subject category)
- art (subject category)
Find in a library
To the university's database