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Placental growth fa...
Placental growth factor and soluble fms-like tyrosine kinase-1 in early-onset and late-onset preeclampsia
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- Wikström, Anna-Karin (författare)
- Uppsala universitet,Institutionen för kvinnors och barns hälsa,Klinisk och experimentell reproduktionsbiologi/Olovsson
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- Larsson, Anders (författare)
- Uppsala universitet,Klinisk kemi
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- Eriksson, Ulf (författare)
- Uppsala universitet,Institutionen för medicinsk cellbiologi,Teratology
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- Nash, Peppi (författare)
- Uppsala universitet,Institutionen för kvinnors och barns hälsa,Institutionen för medicinsk cellbiologi,Klinisk och experimentell reproduktionsbiologi/Olovsson
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- Nordén-Lindeberg, Solveig (författare)
- Uppsala universitet,Institutionen för kvinnors och barns hälsa,Obstetrisk forskning/Axelsson
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- Olovsson, Matts (författare)
- Uppsala universitet,Institutionen för kvinnors och barns hälsa,Klinisk och experimentell reproduktionsbiologi/Olovsson
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(creator_code:org_t)
- 2007
- 2007
- Engelska.
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Ingår i: Obstetrics and Gynecology. - 0029-7844 .- 1873-233X. ; 109:6, s. 1368-1374
- Relaterad länk:
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- OBJECTIVE: To estimate whether alterations in plasma levels of the proangiogenic proteins placental growth factor (PlGF) and vascular endothelial growth factor-A (VEGF-A), and the antiangiogenic protein soluble fms-like tyrosine kinase-1 (sFlt1) were more pronounced in early-onset than in late-onset preeclampsia. METHODS: A cross-sectional study was conducted to estimate the levels of sFlt1, PlGF, and VEGF-A in plasma in a control group of nonpregnant women, in an early control group of women at 24-32 weeks of gestation, in a late control group of women at 36-42 weeks of gestation, and in cases of women with early-onset (before 32 weeks of gestation) and late-onset (after 35 weeks of gestation) preeclampsia. RESULTS: Women with early-onset preeclampsia had a 43 times higher median plasma sFlt1 level than early controls (P<.001). Women with late-onset preeclampsia had a three times higher median plasma sFlt1 level than late controls (P<.001). Women with early-onset preeclampsia had a 21 times lower median plasma PlGF level than early controls (P<.001). Women with late-onset preeclampsia had a five times lower median plasma PlGF level than late controls (P=.01). The median level of VEGF-A in plasma was less than 15 pg/mL in all groups of pregnant women. CONCLUSION: Both early- and late-onset preeclampsia are associated with altered plasma levels of sFlt1 and PlGF. The alterations are more pronounced in early-onset rather than in late-onset disease.
Nyckelord
- MEDICINE
- MEDICIN
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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