Sökning: onr:"swepub:oai:gup.ub.gu.se/106356" > CSF biomarkers and ...
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000 | 09500naa a2201105 4500 | |
001 | oai:gup.ub.gu.se/106356 | |
003 | SwePub | |
008 | 240528s2009 | |||||||||||000 ||eng| | |
009 | oai:DiVA.org:liu-20137 | |
009 | oai:prod.swepub.kib.ki.se:119093998 | |
009 | oai:lup.lub.lu.se:2584ff8e-b83b-46be-b8dd-a8a258dc43ff | |
024 | 7 | a https://gup.ub.gu.se/publication/1063562 URI |
024 | 7 | a https://doi.org/10.1001/jama.2009.10642 DOI |
024 | 7 | a https://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-201372 URI |
024 | 7 | a http://kipublications.ki.se/Default.aspx?queryparsed=id:1190939982 URI |
024 | 7 | a https://lup.lub.lu.se/record/14615542 URI |
040 | a (SwePub)gud (SwePub)liud (SwePub)kid (SwePub)lu | |
041 | a eng | |
042 | 9 SwePub | |
072 | 7 | a ref2 swepub-contenttype |
072 | 7 | a art2 swepub-publicationtype |
100 | 1 | a Mattsson, Niklas,d 1979u Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi,Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry,University of Gothenburg4 aut0 (Swepub:gu)xmattn |
245 | 1 0 | a CSF biomarkers and incipient Alzheimer disease in patients with mild cognitive impairment. |
264 | 1 | b American Medical Association (AMA),c 2009 |
520 | a CONTEXT: Small single-center studies have shown that cerebrospinal fluid (CSF) biomarkers may be useful to identify incipient Alzheimer disease (AD) in patients with mild cognitive impairment (MCI), but large-scale multicenter studies have not been conducted. OBJECTIVE: To determine the diagnostic accuracy of CSF beta-amyloid(1-42) (Abeta42), total tau protein (T-tau), and tau phosphorylated at position threonine 181 (P-tau) for predicting incipient AD in patients with MCI. DESIGN, SETTING, AND PARTICIPANTS: The study had 2 parts: a cross-sectional study involving patients with AD and controls to identify cut points, followed by a prospective cohort study involving patients with MCI, conducted 1990-2007. A total of 750 individuals with MCI, 529 with AD, and 304 controls were recruited by 12 centers in Europe and the United States. Individuals with MCI were followed up for at least 2 years or until symptoms had progressed to clinical dementia. MAIN OUTCOME MEASURES: Sensitivity, specificity, positive and negative likelihood ratios (LRs) of CSF Abeta42, T-tau, and P-tau for identifying incipient AD. RESULTS: During follow-up, 271 participants with MCI were diagnosed with AD and 59 with other dementias. The Abeta42 assay in particular had considerable intersite variability. Patients who developed AD had lower median Abeta42 (356; range, 96-1075 ng/L) and higher P-tau (81; range, 15-183 ng/L) and T-tau (582; range, 83-2174 ng/L) levels than MCI patients who did not develop AD during follow-up (579; range, 121-1420 ng/L for Abeta42; 53; range, 15-163 ng/L for P-tau; and 294; range, 31-2483 ng/L for T-tau, P < .001). The area under the receiver operating characteristic curve was 0.78 (95% confidence interval [CI], 0.75-0.82) for Abeta42, 0.76 (95% CI, 0.72-0.80) for P-tau, and 0.79 (95% CI, 0.76-0.83) for T-tau. Cut-offs with sensitivity set to 85% were defined in the AD and control groups and tested in the MCI group, where the combination of Abeta42/P-tau ratio and T-tau identified incipient AD with a sensitivity of 83% (95% CI, 78%-88%), specificity 72% (95% CI, 68%-76%), positive LR, 3.0 (95% CI, 2.5-3.4), and negative LR, 0.24 (95% CI, 0.21-0.28). The positive predictive value was 62% and the negative predictive value was 88%. CONCLUSIONS: This multicenter study found that CSF Abeta42, T-tau, and P-tau identify incipient AD with good accuracy, but less accurately than reported from single-center studies. Intersite assay variability highlights a need for standardization of analytical techniques and clinical procedures. | |
650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Psykiatri0 (SwePub)302152 hsv//swe |
650 | 7 | a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Psychiatry0 (SwePub)302152 hsv//eng |
650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Medicinska och farmaceutiska grundvetenskaperx Neurovetenskaper0 (SwePub)301052 hsv//swe |
650 | 7 | a MEDICAL AND HEALTH SCIENCESx Basic Medicinex Neurosciences0 (SwePub)301052 hsv//eng |
650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Neurologi0 (SwePub)302072 hsv//swe |
650 | 7 | a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Neurology0 (SwePub)302072 hsv//eng |
653 | a Adult | |
653 | a Aged | |
653 | a Aged | |
653 | a 80 and over | |
653 | a Alzheimer Disease | |
653 | a cerebrospinal fluid | |
653 | a diagnosis | |
653 | a Amyloid beta-Protein | |
653 | a cerebrospinal fluid | |
653 | a Biological Markers | |
653 | a cerebrospinal fluid | |
653 | a Cognition Disorders | |
653 | a cerebrospinal fluid | |
653 | a Cohort Studies | |
653 | a Cross-Sectional Studies | |
653 | a Female | |
653 | a Humans | |
653 | a Male | |
653 | a Middle Aged | |
653 | a Peptide Fragments | |
653 | a cerebrospinal fluid | |
653 | a Phosphothreonine | |
653 | a Sensitivity and Specificity | |
653 | a tau Proteins | |
653 | a cerebrospinal fluid | |
653 | a chemistry | |
653 | a MEDICINE | |
700 | 1 | a Zetterberg, Henrik,d 1973u Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi,Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry,University of Gothenburg4 aut0 (Swepub:gu)xzethe |
700 | 1 | a Hansson, Oskaru Lund University,Lunds universitet,Klinisk minnesforskning,Forskargrupper vid Lunds universitet,Clinical Memory Research,Lund University Research Groups4 aut0 (Swepub:lu)mphy-ohn |
700 | 1 | a Andreasen, Nielsu Karolinska Institutet4 aut |
700 | 1 | a Parnetti, Lucillau University of Perugia, Italy4 aut |
700 | 1 | a Jonsson, Michael,d 1955u Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi,Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry,University of Gothenburg4 aut0 (Swepub:gu)xjonmi |
700 | 1 | a Herukka, Sanna-Kaisau University of Kuopio, Finland4 aut |
700 | 1 | a Marcusson, Janu Östergötlands Läns Landsting,Linköpings universitet,Geriatrik,Hälsouniversitetet,Geriatriska kliniken4 aut0 (Swepub:liu)janma25 |
700 | 1 | a Blankenstein, Marinus Au Vrije University Medical Center, Amsterdam, the Netherlands4 aut |
700 | 1 | a Ewers, Michaelu Karolinska Institutet4 aut |
700 | 1 | a Rich, Kennethu New York University, USA4 aut |
700 | 1 | a Kaiser, Elmaru University of Heidelberg, Germany4 aut |
700 | 1 | a Verbeek, Marcelu Radboud University Medical Centre, Nijmegen, the Netherlands4 aut |
700 | 1 | a Tsolaki, Magdau Aristotle University of Thessaloniki, Greece4 aut |
700 | 1 | a Mulugeta, Ezrau Stavanger University Hospital, Norway4 aut |
700 | 1 | a Rosén, Eriku University of Gothenburg4 aut |
700 | 1 | a Aarsland, Dagu Karolinska Institutet4 aut |
700 | 1 | a Visser, Pieter Jelleu University of Maastricht, the Netherlands4 aut |
700 | 1 | a Schröder, Johannesu University of Heidelberg, Germany4 aut |
700 | 1 | a Marcusson, Jan4 aut |
700 | 1 | a de Leon, Monyu New York University, USA4 aut |
700 | 1 | a Hampel, Haraldu University of Dublin, Ireland4 aut |
700 | 1 | a Scheltens, Philipu Vrije University Medical Center, Amsterdam, the Netherlands4 aut |
700 | 1 | a Pirttilä, Tuulau University of Kuopio, Finland4 aut |
700 | 1 | a Wallin, Anders,d 1950u Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi,Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry,University of Gothenburg4 aut0 (Swepub:gu)xwaand |
700 | 1 | a Jönhagen, Maria Eriksdotteru Karolinska Institutet, Huddinge University Hospital, Stockholm4 aut |
700 | 1 | a Minthon, Lennartu Lund University,Lunds universitet,Klinisk minnesforskning,Forskargrupper vid Lunds universitet,Clinical Memory Research,Lund University Research Groups4 aut0 (Swepub:lu)psyk-lmi |
700 | 1 | a Winblad, Bengtu Karolinska Institutet4 aut |
700 | 1 | a Blennow, Kaj,d 1958u Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi,Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry,University of Gothenburg4 aut0 (Swepub:gu)xbleka |
710 | 2 | a Göteborgs universitetb Institutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi4 org |
773 | 0 | t JAMA : the journal of the American Medical Associationd : American Medical Association (AMA)g 302:4, s. 385-93q 302:4<385-93x 1538-3598x 0098-7484 |
773 | 0 | t JAMAd : American Medical Association (AMA)g 302:4, s. 385-93q 302:4<385-93x 0098-7484 |
856 | 4 | u https://jamanetwork.com/journals/jama/articlepdf/184311/joc90069_385_393.pdf |
856 | 4 8 | u https://gup.ub.gu.se/publication/106356 |
856 | 4 8 | u https://doi.org/10.1001/jama.2009.1064 |
856 | 4 8 | u https://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-20137 |
856 | 4 8 | u http://kipublications.ki.se/Default.aspx?queryparsed=id:119093998 |
856 | 4 8 | u https://lup.lub.lu.se/record/1461554 |
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