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Controlled release ...
Controlled release of matrix metalloproteinase 1 with or without skeletal myoblasts transplantation improves cardiac function of rat hearts with chronic myocardial infarction.
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Lin, Xue (author)
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Tammbara, Keiichi (author)
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- Fu, Michael, 1963 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för molekylär och klinisk medicin,Institute of Medicine, Department of Molecular and Clinical Medicine
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Yamamoto, Masaya (author)
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- Premaratne, Goditha U (author)
- Gothenburg University,Göteborgs universitet,Institutionen för medicin,Institute of Medicine
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Sakakibara, Yutaka (author)
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Marui, Akira (author)
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Ikeda, Tadashi (author)
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Komeda, Masashi (author)
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Tabata, Yasuhiko (author)
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(creator_code:org_t)
- Mary Ann Liebert Inc, 2009
- 2009
- English.
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In: Tissue engineering. Part A. - : Mary Ann Liebert Inc. - 1937-335X .- 1937-3341. ; 15:9, s. 2699-706
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https://doi.org/10.1...
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Abstract
Subject headings
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- Skeletal myoblast transplantation has been applied clinically for severe ischemic cardiomyopathy. Matrix metalloproteinase 1 (MMP-1) reduces fibrosis and prevents the progress of heart failure. We hypothesized that MMP-1 administration to the infarct area enhances the efficacy of skeletal myoblast transplantation. The controlled release of MMP-1 improved cardiac functions of rats with chronic myocardiac infarction with or without transplantation of skeletal myoblasts. Improvement in cardiac function and small fibrotic area inside the infarcted area were observed compared with those of myoblast transplantation. In conclusion, controlled release of MMP-1 was effective in cardioprotection in postmyocardial infarction although the combination with cell transplantation showed the similar effect.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Fysiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Physiology (hsv//eng)
Keyword
- Animals
- administration & dosage
- Heart Function Tests
- Humans
- Matrix Metalloproteinase 1
- administration & dosage
- Myoblasts
- Skeletal
- transplantation
- Myocardial Infarction
- pathology
- physiopathology
- therapy
- ultrasonography
- Myocardium
- pathology
- Organ Size
- Plasmids
- administration & dosage
- Rats
- Rats
- Inbred Lew
- Tissue Donors
Publication and Content Type
- ref (subject category)
- art (subject category)
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- By the author/editor
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Lin, Xue
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Tammbara, Keiich ...
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Fu, Michael, 196 ...
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Yamamoto, Masaya
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Premaratne, Godi ...
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Sakakibara, Yuta ...
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show more...
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Marui, Akira
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Ikeda, Tadashi
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Komeda, Masashi
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Tabata, Yasuhiko
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show less...
- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Basic Medicine
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and Physiology
- Articles in the publication
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Tissue engineeri ...
- By the university
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University of Gothenburg