Genetic variation in the transforming growth factor-beta1 gene is associated with susceptibility to IgA nephropathy

• BACKGROUND: There is growing evidence of genetic risk for susceptibility to IgA nephropathy. Among several candidate genes related to immunological regulation in renal tissue, TGFB1 is known to be a contributor to proliferation and the development of fibrosis. METHODS: We analysed several SNPs in a region of this gene using 212 DNA samples from biopsy-proven IgA nephropathy patients, 146 men and 66 women and 477 healthy age-matched controls (321 men and 156 women) from the same population in Sweden. RESULTS: Frequencies of four out of five selected SNPs (rs6957, rs2241715, rs1800471, rs1982073 and rs1800469) were found to significantly differ between male patients and male controls in a co-dominant model (corrected P

Ämnesord

MEDICIN OCH HÄLSOVETENSKAP  -- Medicinska och farmaceutiska grundvetenskaper -- Immunologi inom det medicinska området (hsv//swe)

MEDICAL AND HEALTH SCIENCES  -- Basic Medicine -- Immunology in the medical area (hsv//eng)

Nyckelord

Adolescent

Adult

Aged

Female

Genetic Predisposition to Disease

Genetic Variation

Glomerulonephritis

IGA

genetics

Humans

Male

Middle Aged

Polymorphism

Single Nucleotide

Transforming Growth Factor beta1

genetics

Young Adult

MEDICINE

Publikations- och innehållstyp

ref (ämneskategori)

art (ämneskategori)