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FältnamnIndikatorerMetadata
00005103naa a2200937 4500
001oai:gup.ub.gu.se/127470
003SwePub
008240528s2010 | |||||||||||000 ||eng|
0247 a https://gup.ub.gu.se/publication/1274702 URI
0247 a https://doi.org/10.1016/j.jalz.2010.03.0082 DOI
040 a (SwePub)gu
041 a eng
042 9 SwePub
072 7a ref2 swepub-contenttype
072 7a for2 swepub-publicationtype
1001 a Trojanowski, John Q4 aut
2451 0a Update on the biomarker core of the Alzheimer's Disease Neuroimaging Initiative subjects.
264 c 2010-05
264 1b Wiley,c 2010
520 a Here, we review progress by the Penn Biomarker Core in the Alzheimer's Disease Neuroimaging Initiative (ADNI) toward developing a pathological cerebrospinal fluid (CSF) and plasma biomarker signature for mild Alzheimer's disease (AD) as well as a biomarker profile that predicts conversion of mild cognitive impairment (MCI) and/or normal control subjects to AD. The Penn Biomarker Core also collaborated with other ADNI Cores to integrate data across ADNI to temporally order changes in clinical measures, imaging data, and chemical biomarkers that serve as mileposts and predictors of the conversion of normal control to MCI as well as MCI to AD, and the progression of AD. Initial CSF studies by the ADNI Biomarker Core revealed a pathological CSF biomarker signature of AD defined by the combination of Abeta1-42 and total tau (T-tau) that effectively delineates mild AD in the large multisite prospective clinical investigation conducted in ADNI. This signature appears to predict conversion from MCI to AD. Data fusion efforts across ADNI Cores generated a model for the temporal ordering of AD biomarkers which suggests that Abeta amyloid biomarkers become abnormal first, followed by changes in neurodegenerative biomarkers (CSF tau, F-18 fluorodeoxyglucose-positron emission tomography, magnetic resonance imaging) with the onset of clinical symptoms. The timing of these changes varies in individual patients due to genetic and environmental factors that increase or decrease an individual's resilience in response to progressive accumulations of AD pathologies. Further studies in ADNI will refine this model and render the biomarkers studied in ADNI more applicable to routine diagnosis and to clinical trials of disease modifying therapies.
650 7a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Psykiatri0 (SwePub)302152 hsv//swe
650 7a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Psychiatry0 (SwePub)302152 hsv//eng
653 a Alzheimer Disease
653 a blood
653 a cerebrospinal fluid
653 a diagnosis
653 a Amyloid beta-Protein
653 a metabolism
653 a Aniline Compounds
653 a diagnostic use
653 a Apolipoproteins E
653 a genetics
653 a Biological Markers
653 a blood
653 a cerebrospinal fluid
653 a Cognition Disorders
653 a blood
653 a cerebrospinal fluid
653 a Cross-Sectional Studies
653 a Diagnostic Imaging
653 a methods
653 a trends
653 a Homocysteine
653 a metabolism
653 a Humans
653 a Isoprostanes
653 a metabolism
653 a Peptide Fragments
653 a metabolism
653 a Positron-Emission Tomography
653 a methods
653 a Prospective Studies
653 a Reproducibility of Results
653 a Thiazoles
653 a diagnostic use
653 a tau Proteins
653 a metabolism
7001 a Vandeerstichele, Hugo4 aut
7001 a Korecka, Magdalena4 aut
7001 a Clark, Christopher M4 aut
7001 a Aisen, Paul S4 aut
7001 a Petersen, Ronald C4 aut
7001 a Blennow, Kaj,d 1958u Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi,Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry4 aut0 (Swepub:gu)xbleka
7001 a Soares, Holly4 aut
7001 a Simon, Adam4 aut
7001 a Lewczuk, Piotr4 aut
7001 a Dean, Robert4 aut
7001 a Siemers, Eric4 aut
7001 a Potter, William Z4 aut
7001 a Weiner, Michael W4 aut
7001 a Jack, Clifford R4 aut
7001 a Jagust, William4 aut
7001 a Toga, Arthur W4 aut
7001 a Lee, Virginia M-Y4 aut
7001 a Shaw, Leslie M4 aut
7102 a Göteborgs universitetb Institutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi4 org
7730 t Alzheimer's & dementia : the journal of the Alzheimer's Associationd : Wileyg 6:3, s. 230-8q 6:3<230-8x 1552-5279
7730 t Alzheimer's & Dementiad : Wileyg 6:3, s. 230-8q 6:3<230-8x 1552-5260
8564 u https://europepmc.org/articles/pmc2867838?pdf=render
8564 8u https://gup.ub.gu.se/publication/127470
8564 8u https://doi.org/10.1016/j.jalz.2010.03.008

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