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Serum uric acid is ...
Serum uric acid is associated with new-onset diabetes in hypertensive patients with left ventricular hypertrophy: The LIFE Study
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- Wiik, B. P. (författare)
- Department of Cardiology and Department of Nephrology, Oslo University Hospital, Norway
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- Larstorp, A. C. (författare)
- Department of Cardiology and Department of Nephrology, Oslo University Hospital, Norway
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- Hoieggen, A. (författare)
- Department of Cardiology and Department of Nephrology, Oslo University Hospital, Norway
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- Kjeldsen, S. E. (författare)
- Department of Cardiology and Department of Nephrology, Oslo University Hospital, Norway,Department of Cardiovascular Medicine, University of Michigan, Ann Arbor, Michigan, USA
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- Olsen, M. H. (författare)
- The Cardiovascular Research Unit, Cardiology Section, Department of Internal Medicine, Glostrup University Hospital, Glostrup, Denmark,Division of Cardiology, Holbaek Hospital, Holbaek, Denmark
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Ibsen, H. (författare)
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- Lindholm, Lars H (författare)
- Umeå universitet,Allmänmedicin
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- Dahlöf, Björn, 1953 (författare)
- Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för akut och kardiovaskulär medicin,Institute of Medicine, Department of Emergeny and Cardiovascular Medicine,Department of Medicine, Sahlgrenska University Hospital/östra, Göteborg, Sweden
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- Devereux, R. B. (författare)
- Greenberg Division of Cardiology, Weill Cornell Medical College, New York, New York, USA
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- Okin, P. M. (författare)
- Greenberg Division of Cardiology, Weill Cornell Medical College, New York, New York, USA
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- Wachtell, K. (författare)
- The Heart Center, Rigshospitalet, Copenhagen, Denmark
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(creator_code:org_t)
- Nature Publishing Group, 2010
- 2010
- Engelska.
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Ingår i: American Journal of Hypertension. - : Nature Publishing Group. - 0895-7061 .- 1941-7225. ; 23:8, s. 845-851
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Abstract
Ämnesord
Stäng
- BACKGROUND: It is unclear whether serum uric acid (SUA) is associated with development of new-onset diabetes (NOD) in patients with hypertension and left ventricular hypertrophy (LVH). The aim of the present investigation was to test the hypothesis that SUA predicts development of NOD in these patients. METHODS: In the Losartan Intervention For Endpoint reduction in hypertension (LIFE) study, a double-masked, parallel-group design, 9,193 patients with hypertension and electrocardiographic LVH were randomized to losartan- or atenolol-based antihypertensive treatment and followed for a mean of 4.9 years. At baseline, 7,489 patients with available SUA measurements did not have diabetes mellitus and were thus at risk of its development during the study. We used Cox regression analyses to investigate whether SUA predicted development of NOD. RESULTS: NOD developed in 522 of 7,489 patients. The association between baseline SUA and development of NOD was significant (hazard ratio (HR) 1.29 per s.d. (1.3 mg/dl), 95% confidence interval (CI) 1.18-1.42, P < 0.001) after adjustment for treatment with losartan vs. atenolol, baseline serum glucose, urinary albumin/creatinine ratio, estimated glomerular filtration rate and Framingham risk score, time-varying systolic and diastolic blood pressure, and time-varying LVH by Cornell voltage-duration product and Sokolow-Lyon voltage. In parallel analyses, baseline quartiles of SUA were significantly associated with increasing NOD (HR 1.28, 95% CI 1.18-1.40, P < 0.001). Time-varying SUA was also associated with NOD (HR 1.10 per s.d. [1.3 mg/dl], 95% CI 1.02-1.19, P = 0.015). CONCLUSION: Our analysis suggests that SUA is an independent risk marker for NOD in hypertensive patients with LVH.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Kardiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cardiac and Cardiovascular Systems (hsv//eng)
Nyckelord
- Aged
- Antihypertensive Agents/therapeutic use
- Atenolol/therapeutic use
- Diabetes Mellitus
- Type 2/*etiology
- Female
- Humans
- Hypertension/*complications
- Hypertrophy
- Left Ventricular/*complications
- Losartan/*therapeutic use
- Male
- Middle Aged
- Risk Factors
- Uric Acid/*blood
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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Wiik, B. P.
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Larstorp, A. C.
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Hoieggen, A.
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Kjeldsen, S. E.
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Olsen, M. H.
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Ibsen, H.
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Lindholm, Lars H
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Dahlöf, Björn, 1 ...
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Devereux, R. B.
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Okin, P. M.
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Wachtell, K.
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