Search: onr:"swepub:oai:gup.ub.gu.se/135153" >
Differential effect...
Differential effects of efavirenz, lopinavir/r, and atazanavir/r on the initial viral decay rate in treatment naïve HIV-1-infected patients.
-
- Edén, Arvid, 1975 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för biomedicin, avdelningen för infektionssjukdomar,Institute of Biomedicine, Department of Infectious Medicine,University of Gothenburg
-
- Andersson, Lars-Magnus, 1968 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för biomedicin, avdelningen för infektionssjukdomar,Institute of Biomedicine, Department of Infectious Medicine,University of Gothenburg
-
Andersson, Orjan (author)
-
show more...
-
- Flamholc, Leo (author)
- Lund University,Lunds universitet,Enheten för infektionssjukdomar,Forskargrupper vid Lunds universitet,Infectious Diseases Research Unit,Lund University Research Groups,Skånes universitetssjukhus (SUS),Skåne University Hospital
-
- Josephson, Filip (author)
- Karolinska universitetssjukhuset,Karolinska University Hospital
-
- Nilsson, Staffan, 1956 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för matematiska vetenskaper, matematisk statistik,Department of Mathematical Sciences, Mathematical Statistics,Chalmers tekniska högskola,Chalmers University of Technology,University of Gothenburg
-
- Ormaasen, Vidar (author)
- Oslo universitetssykehus,Oslo University Hospital
-
- Svedhem, Veronica (author)
- Karolinska Institutet
-
- Säll, Christer (author)
- Södra Älvsborgs Sjukhus (SÄS),Södra Älvsborg Hospital (SÄS)
-
- Sönnerborg, Anders (author)
- Karolinska Institutet
-
- Tunbäck, Petra, 1965 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för kliniska vetenskaper, Avdelningen för dermatologi och venereologi,Institute of Clinical Sciences, Department of Dermatology and Venereology,University of Gothenburg
-
- Gisslén, Magnus, 1962 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för biomedicin, avdelningen för infektionssjukdomar,Institute of Biomedicine, Department of Infectious Medicine,University of Gothenburg
-
show less...
-
(creator_code:org_t)
- Mary Ann Liebert Inc, 2010
- 2010
- English.
-
In: AIDS research and human retroviruses. - : Mary Ann Liebert Inc. - 1931-8405 .- 0889-2229. ; 26:5, s. 533-40
- Related links:
-
http://www.lieberton...
-
show more...
-
http://dx.doi.org/10...
-
https://gup.ub.gu.se...
-
https://doi.org/10.1...
-
https://lup.lub.lu.s...
-
https://research.cha...
-
http://kipublication...
-
show less...
Abstract
Subject headings
Close
- Initial viral decay rate may be useful when comparing the relative potency of antiretroviral regimens. Two hundred twenty-seven ART-naïve patients were randomized to receive efavirenz (EFV) (n = 74), lopinavir/ritonavir (LPV/r) (n = 77), or atazanavir/ritonavir (ATV/r) (n = 79) in combination with two NRTIs. The most frequently used NRTI combinations in the EFV and ATV/r groups were the nonthymidine analogues tenofovir and emtricitabine or lamivudine (70% and 68%, respectively) and, in the LPV/r group, lamivudine and the thymidine analogue zidovudine (89%). HIV-1 RNA was monitored during the first 28 days after treatment initiation. Phase 1 and 2 decay rate was estimated in a subset of 157 patients by RNA decrease from days 0 to 7, and days 14 to 28. One-way ANOVA and subsequent Tukey's post hoc tests were used for groupwise comparisons. Mean (95% CI) HIV-1 RNA reductions from days 0 to 28 were 2.59 (2.45-2.73), 2.42 (2.27-2.57), and 2.13 (2.01-2.25) log(10) copies/ml for the EFV-, LPV/r-, and ATV/r-based treatment groups, respectively, with a significantly larger decrease in the EFV-based group at all time points compared with ATV/r (p < 0.0001), and with LPV/r at days 7-21 (p < 0.0001-0.03). LPV/r gave a greater RNA decrease compared with ATV/r from day 14 (p = 0.02). Phase 1 decay rate was significantly higher in the EFV group compared with LPV/r (p = 0.003) or ATV/r (p < 0.0001). No difference was found in phase 2 decrease. EFV-based treatment gave a more rapid decline in HIV-1 RNA than did either of the boosted protease inhibitor-based regimens. The observed differences may reflect different inherent regimen potencies.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Mikrobiologi inom det medicinska området (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Microbiology in the medical area (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Infektionsmedicin (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Infectious Medicine (hsv//eng)
Keyword
- Adult
- Aged
- Anti-HIV Agents
- pharmacology
- therapeutic use
- Benzoxazines
- pharmacology
- therapeutic use
- Drug Therapy
- Combination
- Female
- HIV Infections
- drug therapy
- virology
- HIV-1
- drug effects
- Humans
- Male
- Middle Aged
- Oligopeptides
- pharmacology
- therapeutic use
- Pyridines
- pharmacology
- therapeutic use
- Pyrimidinones
- pharmacology
- therapeutic use
- RNA
- Viral
- blood
- drug effects
- Reverse Transcriptase Inhibitors
- pharmacology
- therapeutic use
- Treatment Outcome
- HIV Infections
Publication and Content Type
- ref (subject category)
- art (subject category)
Find in a library
To the university's database
- By the author/editor
-
Edén, Arvid, 197 ...
-
Andersson, Lars- ...
-
Andersson, Orjan
-
Flamholc, Leo
-
Josephson, Filip
-
Nilsson, Staffan ...
-
show more...
-
Ormaasen, Vidar
-
Svedhem, Veronic ...
-
Säll, Christer
-
Sönnerborg, Ande ...
-
Tunbäck, Petra, ...
-
Gisslén, Magnus, ...
-
show less...
- About the subject
-
- MEDICAL AND HEALTH SCIENCES
-
MEDICAL AND HEAL ...
-
and Basic Medicine
-
and Microbiology in ...
-
- MEDICAL AND HEALTH SCIENCES
-
MEDICAL AND HEAL ...
-
and Clinical Medicin ...
-
and Infectious Medic ...
- Articles in the publication
-
AIDS research an ...
- By the university
-
University of Gothenburg
-
Lund University
-
Chalmers University of Technology
-
Karolinska Institutet