Bacteria penetrate the inner mucus layer before inflammation in the dextran sulfate colitis model.

Johansson, Malin E V,1971Gothenburg University,Göteborgs universitet,Institutionen för biomedicin, avdelningen för medicinsk kemi och cellbiologi,Institute of Biomedicine, Department of Medical Biochemistry and Cell Biology (author)

Protection of the large intestine with its enormous amount of commensal bacteria is a challenge that became easier to understand when we recently could describe that colon has an inner attached mucus layer devoid of bacteria (Johansson et al. (2008) Proc. Natl. Acad. Sci. USA 105, 15064-15069). The bacteria are thus kept at a distance from the epithelial cells and lack of this layer, as in Muc2-null mice, allow bacteria to contact the epithelium. This causes colitis and later on colon cancer, similar to the human disease Ulcerative Colitis, a disease that still lacks a pathogenetic explanation. Dextran Sulfate (DSS) in the drinking water is the most widely used animal model for experimental colitis. In this model, the inflammation is observed after 3-5 days, but early events explaining why DSS causes this has not been described.

MEDICIN OCH HÄLSOVETENSKAP Medicinsk bioteknologi Medicinsk bioteknologi hsv//swe
MEDICAL AND HEALTH SCIENCES Medical Biotechnology Medical Biotechnology hsv//eng
MEDICIN OCH HÄLSOVETENSKAP Klinisk medicin Gastroenterologi hsv//swe
MEDICAL AND HEALTH SCIENCES Clinical Medicine Gastroenterology and Hepatology hsv//eng
Adult
Aged
Animals
Bacteria
metabolism
Colitis
chemically induced
metabolism
microbiology
pathology
Colon
microbiology
Dextran Sulfate
pharmacology
Disease Models
Animal
Female
Humans
Intestinal Mucosa
metabolism
microbiology
Male
Mice
Mice
Inbred C57BL
Permeability
Time Factors
MEDICINE

Gustafsson, Jenny K,1981Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för invärtesmedicin,Institutionen för biomedicin, avdelningen för medicinsk kemi och cellbiologi,Institute of Medicine, Department of Internal Medicine,Institute of Biomedicine, Department of Medical Biochemistry and Cell Biology(Swepub:gu)xgjenv (author)
Sjöberg, Karolina EGothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för invärtesmedicin,Institutionen för biomedicin, avdelningen för medicinsk kemi och cellbiologi,Institute of Medicine, Department of Internal Medicine,Institute of Biomedicine, Department of Medical Biochemistry and Cell Biology (author)
Petersson, JoelUppsala universitet,Integrativ Fysiologi (author)
Holm, LenaUppsala universitet,Integrativ Fysiologi(Swepub:uu)pho23887 (author)
Sjövall, Henrik,1954Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för invärtesmedicin,Institute of Medicine, Department of Internal Medicine(Swepub:gu)xsjovh (author)
Hansson, Gunnar C.,1951Gothenburg University,Göteborgs universitet,Institutionen för biomedicin, avdelningen för medicinsk kemi och cellbiologi,Institute of Biomedicine, Department of Medical Biochemistry and Cell Biology(Swepub:gu)xhagun (author)
Göteborgs universitetInstitutionen för biomedicin, avdelningen för medicinsk kemi och cellbiologi (creator_code:org_t)

By the author/editor: Johansson, Malin ...; Gustafsson, Jenn ...; Sjöberg, Karolin ...; Petersson, Joel; Holm, Lena; Sjövall, Henrik, ...; show more...; Hansson, Gunnar ...; show less...

About the subject

MEDICAL AND HEALTH SCIENCES: MEDICAL AND HEAL ...; and Medical Biotechn ...; and Medical Biotechn ...

MEDICAL AND HEALTH SCIENCES: MEDICAL AND HEAL ...; and Clinical Medicin ...; and Gastroenterology ...

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