Sökning: onr:"swepub:oai:gup.ub.gu.se/142188" >
Umbilical Cord Bloo...
Umbilical Cord Blood Transplantation for Children with Thalassemia and Sickle Cell Disease.
-
Ruggeri, Annalisa (författare)
-
Eapen, Mary (författare)
-
Scaravadou, Andromachi (författare)
-
visa fler...
-
Cairo, Mitchell S (författare)
-
Bhatia, Monica (författare)
-
Kurtzberg, Joanne (författare)
-
Wingard, John R (författare)
-
- Fasth, Anders, 1945 (författare)
- Gothenburg University,Göteborgs universitet,Institutionen för kliniska vetenskaper, Avdelningen för pediatrik,Institute of Clinical Sciences, Department of Pediatrics
-
Lo Nigro, Luca (författare)
-
Ayas, Mouhab (författare)
-
Purtill, Duncan (författare)
-
Boudjedir, Karim (författare)
-
Chaves, Wagnara (författare)
-
Walters, Mark C (författare)
-
Wagner, John (författare)
-
Gluckman, Eliane (författare)
-
Rocha, Vanderson (författare)
-
visa färre...
-
(creator_code:org_t)
- Elsevier BV, 2011
- 2011
- Engelska.
-
Ingår i: Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation. - : Elsevier BV. - 1523-6536.
- Relaterad länk:
-
http://www.bbmt.org/...
-
visa fler...
-
https://gup.ub.gu.se...
-
https://doi.org/10.1...
-
visa färre...
Abstract
Ämnesord
Stäng
- We examined the efficacy of unrelated cord blood (CB) transplantation in children with thalassemia (n = 35) and sickle cell disease (n = 16), using data reported to 3 registries. Donor-recipient pairs were matched at HLA-A and -B (antigen level) and DRB1 (allele level) in 7 or HLA mismatched at 1 (n = 18), 2 (n = 25), or 3 loci (n = 1). Transplant conditioning was myeloablative (n = 39) or reduced intensity (n = 12). Neutrophil recovery with donor chimerism was documented in 24 patients; 11 patients developed grade II-IV acute graft-versus-host disease (aGVHD) and 10 patients, chronic GVHD (cGVHD). Overall survival (OS) and disease-free survival (DFS) were 62% and 21% for thalassemia and 94% and 50% for sickle cell disease (SCD), respectively. In multivariate analysis, engraftment rate (hazard ratio [HR] 2.2, P = .05) and DFS (HR 0.4, P = .01) were higher with cell dose >5 × 10(7)/kg. The 2-year probability of DFS was 45% in patients who received grafts with cell dose >5 × 10(7)/kg and 13% with lower cell dose. Primary graft failure was the predominant cause of treatment failure occurring in 20 patients with thalassemia and 7 patients with SCD. Primary graft failure was fatal in 5 patients with thalassemia. These results suggest that only CB units containing an expected infused cell dose >5 × 10(7)/kg should be considered for transplantation for hemoglobinopathy.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Pediatrik (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Pediatrics (hsv//eng)
Nyckelord
- hemoglobulinopathies
- hemotopoietic stem cell transplantation
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
Hitta via bibliotek
Till lärosätets databas
- Av författaren/redakt...
-
Ruggeri, Annalis ...
-
Eapen, Mary
-
Scaravadou, Andr ...
-
Cairo, Mitchell ...
-
Bhatia, Monica
-
Kurtzberg, Joann ...
-
visa fler...
-
Wingard, John R
-
Fasth, Anders, 1 ...
-
Lo Nigro, Luca
-
Ayas, Mouhab
-
Purtill, Duncan
-
Boudjedir, Karim
-
Chaves, Wagnara
-
Walters, Mark C
-
Wagner, John
-
Gluckman, Eliane
-
Rocha, Vanderson
-
visa färre...
- Om ämnet
-
- MEDICIN OCH HÄLSOVETENSKAP
-
MEDICIN OCH HÄLS ...
-
och Klinisk medicin
-
och Pediatrik
- Artiklar i publikationen
-
Biology of blood ...
-
Biology of Blood ...
- Av lärosätet
-
Göteborgs universitet