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IL-2 induces a WAVE...
IL-2 induces a WAVE2-dependent pathway for actin reorganization that enables WASp-independent human NK cell function.
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Orange, Jordan S (författare)
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Roy-Ghanta, Sumita (författare)
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Mace, Emily M (författare)
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Maru, Saumya (författare)
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Rak, Gregory D (författare)
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Sanborn, Keri B (författare)
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- Fasth, Anders, 1945 (författare)
- Gothenburg University,Göteborgs universitet,Institutionen för kliniska vetenskaper, Avdelningen för pediatrik,Institute of Clinical Sciences, Department of Pediatrics
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Saltzman, Rushani (författare)
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Paisley, Allison (författare)
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Monaco-Shawver, Linda (författare)
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Banerjee, Pinaki P (författare)
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Pandey, Rahul (författare)
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(creator_code:org_t)
- 2011
- 2011
- Engelska.
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Ingår i: The Journal of clinical investigation. - 1558-8238. ; 121:4, s. 1535-48
- Relaterad länk:
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https://gup.ub.gu.se...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- Wiskott-Aldrich syndrome (WAS) is a primary immunodeficiency associated with an increased susceptibility to herpesvirus infection and hematologic malignancy as well as a deficiency of NK cell function. It is caused by defective WAS protein (WASp). WASp facilitates filamentous actin (F-actin) branching and is required for F-actin accumulation at the NK cell immunological synapse and NK cell cytotoxicity ex vivo. Importantly, the function of WASp-deficient NK cells can be restored in vitro after exposure to IL-2, but the mechanisms underlying this remain unknown. Using a WASp inhibitor as well as cells from patients with WAS, we have defined a direct effect of IL-2 signaling upon F-actin that is independent of WASp function. We found that IL-2 treatment of a patient with WAS enhanced the cytotoxicity of their NK cells and the F-actin content at the immunological synapses formed by their NK cells. IL-2 stimulation of NK cells in vitro activated the WASp homolog WAVE2, which was required for inducing WASp-independent NK cell function, but not for baseline activity. Thus, WAVE2 and WASp define parallel pathways to F-actin reorganization and function in human NK cells; although WAVE2 was not required for NK cell innate function, it was accessible through adaptive immunity via IL-2. These results demonstrate how overlapping cytoskeletal activities can utilize immunologically distinct pathways to achieve synonymous immune function.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Pediatrik (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Pediatrics (hsv//eng)
Nyckelord
- Wiskott Aldrich syndrome
- primary immunodeficiency
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- ref (ämneskategori)
- art (ämneskategori)
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Orange, Jordan S
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Roy-Ghanta, Sumi ...
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Mace, Emily M
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Maru, Saumya
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Rak, Gregory D
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Sanborn, Keri B
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visa fler...
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Fasth, Anders, 1 ...
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Saltzman, Rushan ...
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Paisley, Allison
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Monaco-Shawver, ...
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Banerjee, Pinaki ...
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Pandey, Rahul
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visa färre...
- Om ämnet
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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och Klinisk medicin
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och Pediatrik
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The Journal of c ...
- Av lärosätet
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Göteborgs universitet