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Increased cell-medi...
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Franzen-Röhl, ElisabethKarolinska Institutet
(author)
Increased cell-mediated immune responses in patients with recurrent herpes simplex virus type 2 meningitis.
- Article/chapterEnglish2011
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LIBRIS-ID:oai:gup.ub.gu.se/159312
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https://gup.ub.gu.se/publication/159312URI
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https://doi.org/10.1128/CVI.00333-10DOI
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http://kipublications.ki.se/Default.aspx?queryparsed=id:122314832URI
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Subject category:ref swepub-contenttype
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Subject category:art swepub-publicationtype
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The clinical picture of herpes simplex virus type 2 (HSV-2) infection includes genital blisters and less frequently meningitis, and some individuals suffer from recurrent episodes of these manifestations. We hypothesized that adaptive and/or innate immune functional deficiencies may be a major contributing factor in susceptibility to recurrent HSV-2 meningitis. Ten patients with recurrent HSV-2 meningitis were studied during clinical remission. For comparison, 10 patients with recurrent genital HSV infections as well as 21 HSV-seropositive and 19 HSV-seronegative healthy blood donors were included. HSV-specific T cell blasting and cytokine secretion were evaluated in whole blood cultures. HSV-2-induced NK cell gamma interferon production, dendritic cell Toll-like receptor (TLR) expression, and TLR agonist-induced alpha interferon secretion were analyzed. Patients with recurrent HSV-2 meningitis had elevated T cell blasting and Th1 and Th2 cytokine production in response to HSV antigens compared to those of patients with recurrent genital infections. A somewhat increased NK cell response, increased dendritic cell expression of TLR3 and -9, and increased TLR-induced alpha interferon responses were also noted. Contrary to our expectation, recurrent HSV-2 meningitis patients have increased HSV-specific adaptive and innate immune responses, raising the possibility of immune-mediated pathology in the development of recurrent HSV2 meningitis.
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Schepis, DanikaKarolinska Institutet
(author)
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Lagrelius, Maria
(author)
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Franck, Kristina
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Jones, Petra
(author)
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Liljeqvist, Jan-Åke,1954Gothenburg University,Göteborgs universitet,Institutionen för biomedicin, avdelningen för infektionssjukdomar,Institute of Biomedicine, Department of Infectious Medicine(Swepub:gu)xljanl
(author)
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Bergström, Tomas,1950Gothenburg University,Göteborgs universitet,Institutionen för biomedicin, avdelningen för infektionssjukdomar,Institute of Biomedicine, Department of Infectious Medicine(Swepub:gu)xberto
(author)
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Aurelius, ElisabethKarolinska Institutet
(author)
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Kärre, KlasKarolinska Institutet
(author)
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Berg, LouiseKarolinska Institutet
(author)
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Gaines, Hans
(author)
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Karolinska InstitutetInstitutionen för biomedicin, avdelningen för infektionssjukdomar
(creator_code:org_t)
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In:Clinical and vaccine immunology : CVI18:4, s. 655-601556-679X
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Franzen-Röhl, El ...
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Schepis, Danika
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Lagrelius, Maria
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Franck, Kristina
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Jones, Petra
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Liljeqvist, Jan- ...
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Bergström, Tomas ...
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Aurelius, Elisab ...
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Kärre, Klas
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Berg, Louise
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Gaines, Hans
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University of Gothenburg
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Karolinska Institutet