Increased cell-mediated immune responses in patients with recurrent herpes simplex virus type 2 meningitis.

The clinical picture of herpes simplex virus type 2 (HSV-2) infection includes genital blisters and less frequently meningitis, and some individuals suffer from recurrent episodes of these manifestations. We hypothesized that adaptive and/or innate immune functional deficiencies may be a major contributing factor in susceptibility to recurrent HSV-2 meningitis. Ten patients with recurrent HSV-2 meningitis were studied during clinical remission. For comparison, 10 patients with recurrent genital HSV infections as well as 21 HSV-seropositive and 19 HSV-seronegative healthy blood donors were included. HSV-specific T cell blasting and cytokine secretion were evaluated in whole blood cultures. HSV-2-induced NK cell gamma interferon production, dendritic cell Toll-like receptor (TLR) expression, and TLR agonist-induced alpha interferon secretion were analyzed. Patients with recurrent HSV-2 meningitis had elevated T cell blasting and Th1 and Th2 cytokine production in response to HSV antigens compared to those of patients with recurrent genital infections. A somewhat increased NK cell response, increased dendritic cell expression of TLR3 and -9, and increased TLR-induced alpha interferon responses were also noted. Contrary to our expectation, recurrent HSV-2 meningitis patients have increased HSV-specific adaptive and innate immune responses, raising the possibility of immune-mediated pathology in the development of recurrent HSV2 meningitis.

MEDICIN OCH HÄLSOVETENSKAP Medicinska och farmaceutiska grundvetenskaper Mikrobiologi inom det medicinska området hsv//swe
MEDICAL AND HEALTH SCIENCES Basic Medicine Microbiology in the medical area hsv//eng
Adult
Cytokines
secretion
Dendritic Cells
immunology
Female
Gene Expression
Herpes Simplex
immunology
Herpesvirus 2
Human
immunology
Humans
Immunity
Cellular
Killer Cells
Natural
immunology
Male
Meningitis
Viral
immunology
Middle Aged
Recurrence
T-Lymphocytes
immunology
Toll-Like Receptors
immunology

Schepis, DanikaKarolinska Institutet (author)
Lagrelius, Maria (author)
Franck, Kristina (author)
Jones, Petra (author)
Liljeqvist, Jan-Åke,1954Gothenburg University,Göteborgs universitet,Institutionen för biomedicin, avdelningen för infektionssjukdomar,Institute of Biomedicine, Department of Infectious Medicine(Swepub:gu)xljanl (author)
Bergström, Tomas,1950Gothenburg University,Göteborgs universitet,Institutionen för biomedicin, avdelningen för infektionssjukdomar,Institute of Biomedicine, Department of Infectious Medicine(Swepub:gu)xberto (author)
Aurelius, ElisabethKarolinska Institutet (author)
Kärre, KlasKarolinska Institutet (author)
Berg, LouiseKarolinska Institutet (author)
Gaines, Hans (author)
Karolinska InstitutetInstitutionen för biomedicin, avdelningen för infektionssjukdomar (creator_code:org_t)

By the author/editor: Franzen-Röhl, El ...; Schepis, Danika; Lagrelius, Maria; Franck, Kristina; Jones, Petra; Liljeqvist, Jan- ...; show more...; Bergström, Tomas ...; Aurelius, Elisab ...; Kärre, Klas; Berg, Louise; Gaines, Hans; show less...

About the subject

MEDICAL AND HEALTH SCIENCES: MEDICAL AND HEAL ...; and Basic Medicine; and Microbiology in ...

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