Sökning: onr:"swepub:oai:gup.ub.gu.se/166873" > Human Synovial Lubr...
Fältnamn | Indikatorer | Metadata |
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000 | 04453naa a2200517 4500 | |
001 | oai:gup.ub.gu.se/166873 | |
003 | SwePub | |
008 | 240910s2012 | |||||||||||000 ||eng| | |
009 | oai:prod.swepub.kib.ki.se:125519645 | |
024 | 7 | a https://gup.ub.gu.se/publication/1668732 URI |
024 | 7 | a https://doi.org/10.1074/jbc.M112.3631192 DOI |
024 | 7 | a http://kipublications.ki.se/Default.aspx?queryparsed=id:1255196452 URI |
040 | a (SwePub)gud (SwePub)ki | |
041 | a eng | |
042 | 9 SwePub | |
072 | 7 | a ref2 swepub-contenttype |
072 | 7 | a art2 swepub-publicationtype |
100 | 1 | a Jin, Chunshengu Gothenburg University,Göteborgs universitet,Institutionen för biomedicin, avdelningen för medicinsk kemi och cellbiologi,Institute of Biomedicine, Department of Medical Biochemistry and Cell Biology4 aut0 (Swepub:gu)xjinch |
245 | 1 0 | a Human Synovial Lubricin Expresses Sialyl Lewis x Determinant and Has L-selectin Ligand Activity |
264 | 1 | c 2012 |
520 | a Lubricin (or proteoglycan 4 (PRG4)) is an abundant mucin-like glycoprotein in synovial fluid (SF) and a major component responsible for joint lubrication. In this study, it was shown that O-linked core 2 oligosaccharides (Gal beta 1-3(GlcNAc beta 1-6)GalNAc alpha 1-Thr/Ser) on lubricin isolated from rheumatoid arthritis SF contained both sulfate and fucose residues, and SF lubricin was capable of binding to recombinant L-selectin in a glycosylation-dependent manner. Using resting human polymorphonuclear granulocytes (PMN) from peripheral blood, confocal microscopy showed that lubricin coated circulating PMN and that it partly co-localized with L-selectin expressed by these cells. In agreement with this, activation-induced shedding of L-selectin also mediated decreased lubricin binding to PMN. It was also found that PMN recruited to inflamed synovial area and fluid in rheumatoid arthritis patients kept a coat of lubricin. These observations suggest that lubricin is able to bind to PMN via an L-selectin-dependent and -independent manner and may play a role in PMN-mediated inflammation. | |
650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Medicinsk bioteknologi0 (SwePub)3042 hsv//swe |
650 | 7 | a MEDICAL AND HEALTH SCIENCESx Medical Biotechnology0 (SwePub)3042 hsv//eng |
653 | a superficial zone protein | |
653 | a rheumatoid-arthritis | |
653 | a articular-cartilage | |
653 | a gene-expression | |
653 | a lubricating properties | |
653 | a recombinant lubricin | |
653 | a mass-spectrometry | |
653 | a o-glycans | |
653 | a cells | |
653 | a fluid | |
700 | 1 | a Ekwall, Anna-Karin Hu Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för reumatologi och inflammationsforskning,Institute of Medicine, Department of Rheumatology and Inflammation Research4 aut0 (Swepub:gu)xhannp |
700 | 1 | a Bylund, Johan,d 1975u Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för reumatologi och inflammationsforskning,Institute of Medicine, Department of Rheumatology and Inflammation Research4 aut0 (Swepub:gu)xbyljo |
700 | 1 | a Björkman, Lena,d 1965u Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för reumatologi och inflammationsforskning,Institute of Medicine, Department of Rheumatology and Inflammation Research4 aut0 (Swepub:gu)xblenv |
700 | 1 | a Estrella, R. P.4 aut |
700 | 1 | a Whitelock, J. M.4 aut |
700 | 1 | a Eisler, T.4 aut |
700 | 1 | a Bokarewa, Maria,d 1963u Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för reumatologi och inflammationsforskning,Institute of Medicine, Department of Rheumatology and Inflammation Research4 aut0 (Swepub:gu)xbokma |
700 | 1 | a Karlsson, Niclas G.,d 1966u Gothenburg University,Göteborgs universitet,Institutionen för biomedicin, avdelningen för medicinsk kemi och cellbiologi,Institute of Biomedicine, Department of Medical Biochemistry and Cell Biology4 aut0 (Swepub:gu)xkanic |
710 | 2 | a Göteborgs universitetb Institutionen för biomedicin, avdelningen för medicinsk kemi och cellbiologi4 org |
773 | 0 | t Journal of Biological Chemistryg 287:43, s. 35922-35933q 287:43<35922-35933x 0021-9258x 1083-351X |
856 | 4 8 | u https://gup.ub.gu.se/publication/166873 |
856 | 4 8 | u https://doi.org/10.1074/jbc.M112.363119 |
856 | 4 8 | u http://kipublications.ki.se/Default.aspx?queryparsed=id:125519645 |
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