Highlights of selected recent electrochemical measurements in living systems

• Since the early work carried out by Ralph Adams in the 1970s, electrochemistry has been established as a powerful analytical tool for neuroscience. In this review, we focus on some novel and innovative methods for the electrochemical analysis of biological samples reported during the last five years. Recent findings in the neurochemistry of Drosophila melanogaster, a new and simple animal model, are summarized. A wealth of technical improvements of the electrode materials or of the instrumentation has been used to achieve higher sensitivity or robustness, to detect new biologically relevant analytes or simply to offer new experimental possibilities. Electrochemical imaging of exocytosis, in vivo or in vitro at the single cell level, is also summarized here. Finally, new perspectives and emerging technologies are discussed.

Subject headings

NATURVETENSKAP  -- Kemi -- Oorganisk kemi (hsv//swe)

NATURAL SCIENCES  -- Chemical Sciences -- Inorganic Chemistry (hsv//eng)

Keyword

Bioanalysis

Neurochemistry

Drosophila melanogaster

Electrochemical imaging

In vivo sensing

scan cyclic voltammetry

frog neuromuscular-junctions

carbon-fiber

microelectrodes

individual chromaffin cells

hydrogen-peroxide

intense

release

freeze-fracture

electroanalytical techniques

diamond

microelectrodes

transmitter release

scan cyclic voltammetry

Publication and Content Type

ref (subject category)

art (subject category)