Sökning: onr:"swepub:oai:gup.ub.gu.se/193152" > Cerebrospinal fluid...
Fältnamn | Indikatorer | Metadata |
---|---|---|
000 | 05978naa a2200817 4500 | |
001 | oai:gup.ub.gu.se/193152 | |
003 | SwePub | |
008 | 240528s2012 | |||||||||||000 ||eng| | |
009 | oai:lup.lub.lu.se:bab03b2e-d779-4a25-a886-8f07844d9964 | |
024 | 7 | a https://gup.ub.gu.se/publication/1931522 URI |
024 | 7 | a https://doi.org/10.1007/s00702-012-0797-82 DOI |
024 | 7 | a https://lup.lub.lu.se/record/28839042 URI |
040 | a (SwePub)gud (SwePub)lu | |
041 | a eng | |
042 | 9 SwePub | |
072 | 7 | a ref2 swepub-contenttype |
072 | 7 | a art2 swepub-publicationtype |
100 | 1 | a Daborg, Jonnyu Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för fysiologi,Institute of Neuroscience and Physiology, Department of Physiology4 aut0 (Swepub:gu)xdaboj |
245 | 1 0 | a Cerebrospinal fluid levels of complement proteins C3, C4 and CR1 in Alzheimer's disease. |
264 | c 2012-04-10 | |
264 | 1 | b Springer Science and Business Media LLC,c 2012 |
520 | a Alzheimer's disease (AD) is strongly associated with loss of synapses. The complement system has been shown to be involved in synaptic elimination. Several studies point to an association between AD and the complement system. The purpose of this study was to examine the association of cerebrospinal fluid (CSF) levels of complement components 3 and 4 (C3 and C4, respectively), and complement receptor 1 (CR1) with AD in 43 patients with AD plus dementia, 42 patients with mild cognitive impairment (MCI) who progressed to AD during follow-up (MCI-AD), 42 patients with stable MCI and 44 controls. Complement levels were also applied in a multivariate model to determine if they provided any added value to the core AD biomarkers Aβ42, T-tau and P-tau. We found elevated CSF levels of C3 and C4 in AD compared with MCI without progression to AD, and elevated CSF levels of CR1 in MCI-AD and AD when these groups were merged. These results provide support for aberrant complement regulation as a part in the AD process, but the changes are not diagnostically useful. | |
650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicin0 (SwePub)3022 hsv//swe |
650 | 7 | a MEDICAL AND HEALTH SCIENCESx Clinical Medicine0 (SwePub)3022 hsv//eng |
650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Neurologi0 (SwePub)302072 hsv//swe |
650 | 7 | a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Neurology0 (SwePub)302072 hsv//eng |
653 | a Adult | |
653 | a Aged | |
653 | a Aged | |
653 | a 80 and over | |
653 | a Alzheimer Disease | |
653 | a cerebrospinal fluid | |
653 | a Amyloid beta-Peptides | |
653 | a cerebrospinal fluid | |
653 | a Complement C3 | |
653 | a cerebrospinal fluid | |
653 | a Complement C4 | |
653 | a cerebrospinal fluid | |
653 | a Disease Progression | |
653 | a Female | |
653 | a Humans | |
653 | a Male | |
653 | a Middle Aged | |
653 | a Mild Cognitive Impairment | |
653 | a cerebrospinal fluid | |
653 | a Peptide Fragments | |
653 | a cerebrospinal fluid | |
653 | a Receptors | |
653 | a Complement | |
653 | a metabolism | |
653 | a tau Proteins | |
653 | a cerebrospinal fluid | |
653 | a Alzheimer's disease | |
653 | a Biomarkers | |
653 | a C3 | |
653 | a C4 | |
653 | a CR1 | |
700 | 1 | a Andreasson, Ulf,d 1968u Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi,Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry4 aut0 (Swepub:gu)xaulfz |
700 | 1 | a Pekna, Marcela,d 1966u Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för klinisk neurovetenskap och rehabilitering,Institute of Neuroscience and Physiology, Department of Clinical Neuroscience and Rehabilitation4 aut0 (Swepub:gu)xpekma |
700 | 1 | a Lautner, Ronaldu Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi,Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry4 aut0 (Swepub:gu)xlauro |
700 | 1 | a Hanse, Eric,d 1962u Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för fysiologi,Institute of Neuroscience and Physiology, Department of Physiology4 aut0 (Swepub:gu)xhaeri |
700 | 1 | a Minthon, Lennartu Lund University,Lunds universitet,Klinisk minnesforskning,Forskargrupper vid Lunds universitet,Clinical Memory Research,Lund University Research Groups4 aut0 (Swepub:lu)psyk-lmi |
700 | 1 | a Blennow, Kaj,d 1958u Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi,Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry4 aut0 (Swepub:gu)xbleka |
700 | 1 | a Hansson, Oskaru Lund University,Lunds universitet,Klinisk minnesforskning,Forskargrupper vid Lunds universitet,Clinical Memory Research,Lund University Research Groups4 aut0 (Swepub:lu)mphy-ohn |
700 | 1 | a Zetterberg, Henrik,d 1973u Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi,Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry4 aut0 (Swepub:gu)xzethe |
710 | 2 | a Göteborgs universitetb Institutionen för neurovetenskap och fysiologi, sektionen för fysiologi4 org |
773 | 0 | t Journal of neural transmission (Vienna, Austria : 1996)d : Springer Science and Business Media LLCg 119:7, s. 789-97q 119:7<789-97x 1435-1463x 0300-9564 |
856 | 4 | u http://dx.doi.org/10.1007/s00702-012-0797-8y FULLTEXT |
856 | 4 8 | u https://gup.ub.gu.se/publication/193152 |
856 | 4 8 | u https://doi.org/10.1007/s00702-012-0797-8 |
856 | 4 8 | u https://lup.lub.lu.se/record/2883904 |
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