Proinflammatory cytokines mediate the systemic inflammatory response associated with high-dose cytarabine treatment in children.

• Treatment with high-dose cytarabine (1-beta-D-arabinofuranosylcytosine) is often associated with an acute febrile reaction sometimes including abdominal pain, myalgia, and rash. The similarity of these symptoms to those caused by hypersecretion of cytokines in the systemic inflammatory response syndrome (SIRS) prompted us to investigate the plasma levels of proinflammatory cytokines during treatment of children with high-dose cytarabine.

Subject headings

MEDICIN OCH HÄLSOVETENSKAP  -- Klinisk medicin -- Urologi och njurmedicin (hsv//swe)

MEDICAL AND HEALTH SCIENCES  -- Clinical Medicine -- Urology and Nephrology (hsv//eng)

MEDICIN OCH HÄLSOVETENSKAP  -- Klinisk medicin -- Kardiologi (hsv//swe)

MEDICAL AND HEALTH SCIENCES  -- Clinical Medicine -- Cardiac and Cardiovascular Systems (hsv//eng)

MEDICIN OCH HÄLSOVETENSKAP  -- Klinisk medicin -- Pediatrik (hsv//swe)

MEDICAL AND HEALTH SCIENCES  -- Clinical Medicine -- Pediatrics (hsv//eng)

Keyword

Adolescent

Antimetabolites

Antineoplastic

administration & dosage

adverse effects

immunology

Child

Child

Preschool

Cytarabine

administration & dosage

adverse effects

immunology

Cytokines

blood

immunology

Dose-Response Relationship

Drug

Exanthema

chemically induced

Female

Humans

Inflammation

Infusions

Intravenous

Male

Pain

chemically induced

Risk Factors

Tumor Necrosis Factor-alpha

immunology

secretion

Publication and Content Type

ref (subject category)

art (subject category)