Impact of endogenous thrombopoietin levels on the differential diagnosis of essential thrombocythaemia and reactive thrombocytosis.

• By using the newly commercialized Quantikine human TPO immunoassay, plasma thrombopoietin (TPO) concentrations were measured in 12 patients with essential thrombocythaemia (ET), 13 patients with reactive thrombocytosis (RT) and 11 healthy volunteers. For the healthy volunteers the mean plasma TPO concentration was 21.1+/-11.0 pg/ml. The mean plasma TPO concentration in the group of RT was slightly lower (16.4+/-8.6 pg/ml) but did not differ significantly from the control group. The mean plasma TPO concentration in ET patients (44.1+/-45.2 pg/ml) was significantly (p<0.05) higher than the mean for RT patients, but did not differ statistically from the mean of healthy volunteers. These data suggest a defective clearance of plasma TPO in patients with ET.

Subject headings

MEDICIN OCH HÄLSOVETENSKAP  -- Klinisk medicin (hsv//swe)

MEDICAL AND HEALTH SCIENCES  -- Clinical Medicine (hsv//eng)

Keyword

Adult

Aged

Aged

80 and over

Biological Markers

blood

Diagnosis

Differential

Enzyme-Linked Immunosorbent Assay

Female

Humans

Male

Middle Aged

Observer Variation

Predictive Value of Tests

Reagent Kits

Diagnostic

Reference Values

Thrombocythemia

Essential

blood

diagnosis

Thrombocytosis

blood

diagnosis

Thrombopoietin

blood

Publication and Content Type

ref (subject category)

art (subject category)