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Analysis of liposome model systems by time-of-flight secondary ion mass spectrometry

Lovric, Jelena, 1980 (author)
Chalmers tekniska högskola,Chalmers University of Technology,Department of Chemical and Biological Engineering; Chalmers University of Technology; SE-412 96 Gothenburg Sweden
Keighron, Jacqueline, 1982 (author)
Chalmers tekniska högskola,Chalmers University of Technology,Department of Chemical and Biological Engineering; Chalmers University of Technology; SE-412 96 Gothenburg Sweden
Angerer, Tina B., 1987 (author)
Gothenburg University,Göteborgs universitet,Institutionen för kemi och molekylärbiologi,Department of Chemistry and Molecular Biology,University of Gothenburg,Department of Chemistry and Molecular Biology; University of Gothenburg; SE-412 96 Gothenburg Sweden
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Li, Xianchan, 1982 (author)
Chalmers tekniska högskola,Chalmers University of Technology,Department of Chemical and Biological Engineering; Chalmers University of Technology; SE-412 96 Gothenburg Sweden
Malmberg, Per, 1974 (author)
Chalmers tekniska högskola,Chalmers University of Technology,Department of Chemical and Biological Engineering; Chalmers University of Technology; SE-412 96 Gothenburg Sweden
Fletcher, John S. (author)
Gothenburg University,Göteborgs universitet,Institutionen för kemi och molekylärbiologi,Department of Chemistry and Molecular Biology,University of Gothenburg,Department of Chemistry and Molecular Biology; University of Gothenburg; SE-412 96 Gothenburg Sweden
Ewing, Andrew G, 1957 (author)
Gothenburg University,Göteborgs universitet,Institutionen för kemi och molekylärbiologi,Department of Chemistry and Molecular Biology,University of Gothenburg,Chalmers tekniska högskola,Chalmers University of Technology,Department of Chemical and Biological Engineering; Chalmers University of Technology; SE-412 96 Gothenburg Sweden;Department of Chemistry and Molecular Biology; University of Gothenburg; SE-412 96 Gothenburg Sweden
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 (creator_code:org_t)
2014-10-27
2014
English.
In: Surface and Interface Analysis: 19th International Conference on Secondary Ion Mass Spectrometry (SIMS). - : Wiley. - 0142-2421 .- 1096-9918.
  • Conference paper (peer-reviewed)
Abstract Subject headings
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  • Time-of-flight secondary ion mass spectrometry (ToF-SIMS) is an important technique for studying chemical composition of micrometer scale objects because of its high spatial resolution imaging capabilities and chemical specificity. In this work, we focus on the application of ToF-SIMS to gain insight into the chemistry of micrometer size liposomes as a potential model for neurotransmitter vesicles. Two models of giant liposomes were analyzed: histamine and aqueous two-phase system-containing liposomes. Characterization of the internal structure of single fixed liposomes was carried out both with the Bi-3(+) and C-60(+) ion sources. The depth profiling capability of ToF-SIMS was used to investigate the liposome interior.

Subject headings

TEKNIK OCH TEKNOLOGIER  -- Kemiteknik (hsv//swe)
ENGINEERING AND TECHNOLOGY  -- Chemical Engineering (hsv//eng)

Keyword

liposome
aqueous two-phase system
histamine
ToF-SIMS
depth profile analysis
imaging
aqueous two-phase system

Publication and Content Type

ref (subject category)
kon (subject category)

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