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ARFGAP1 Is Dynamica...
ARFGAP1 Is Dynamically Associated with Lipid Droplets in Hepatocytes
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Gannon, J. (author)
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- Fernandez-Rodriguez, Julia, 1965 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för biomedicin, avdelningen för medicinsk kemi och cellbiologi,Institute of Biomedicine, Department of Medical Biochemistry and Cell Biology
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Alamri, H. (author)
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Feng, S. B. (author)
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Kalantari, F. (author)
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Negi, S. (author)
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Wong, A. H. Y. (author)
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Mazur, A. (author)
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- Asp, Lennart, 1965 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för biomedicin, avdelningen för medicinsk genetik och klinisk genetik,Institute of Biomedicine, Department of Medical and Clinical Genetics
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Fazel, A. (author)
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Salman, A. (author)
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Lazaris, A. (author)
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Metrakos, P. (author)
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Bergeron, J. J. M. (author)
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Nilsson, T. (author)
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(creator_code:org_t)
- 2014-11-14
- 2014
- English.
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In: Plos One. - : Public Library of Science (PLoS). - 1932-6203. ; 9:11
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https://gup.ub.gu.se...
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https://doi.org/10.1...
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Abstract
Subject headings
Close
- The ARF GTPase Activating Protein 1 (ARFGAP1) associates mainly with the cytosolic side of Golgi cisternal membranes where it participates in the formation of both COPI and clathrin-coated vesicles. In this study, we show that ARFGAP1 associates transiently with lipid droplets upon addition of oleate in cultured cells. Also, that addition of cyclic AMP shifts ARFGAP1 from lipid droplets to the Golgi apparatus and that overexpression and knockdown of ARFGAP1 affect lipid droplet formation. Examination of human liver tissue reveals that ARFGAP1 is found associated with lipid droplets at steady state in some but not all hepatocytes.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine (hsv//eng)
Keyword
- ADP-RIBOSYLATION FACTOR
- GTPASE-ACTIVATING PROTEIN
- GOLGI-COMPLEX
- COPI
- VESICLES
- ENDOPLASMIC-RETICULUM
- BINDING PROTEINS
- COATED VESICLES
- PHOSPHOLIPASE-D
- BETA-COP
- ARF
- Multidisciplinary Sciences
- ATES OF AMERICA
- V110
- P13244
Publication and Content Type
- ref (subject category)
- art (subject category)
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Plos One
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To the university's database
- By the author/editor
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Gannon, J.
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Fernandez-Rodrig ...
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Alamri, H.
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Feng, S. B.
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Kalantari, F.
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Negi, S.
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show more...
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Wong, A. H. Y.
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Mazur, A.
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Asp, Lennart, 19 ...
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Fazel, A.
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Salman, A.
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Lazaris, A.
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Metrakos, P.
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Bergeron, J. J. ...
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Nilsson, T.
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show less...
- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
- Articles in the publication
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Plos One
- By the university
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University of Gothenburg