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  • Kuhle, J. (author)

Conversion from clinically isolated syndrome to multiple sclerosis: A large multicentre study

  • Article/chapterEnglish2015

Publisher, publication year, extent ...

  • 2015-02-13
  • SAGE Publications,2015

Numbers

  • LIBRIS-ID:oai:gup.ub.gu.se/220392
  • https://gup.ub.gu.se/publication/220392URI
  • https://doi.org/10.1177/1352458514568827DOI
  • http://kipublications.ki.se/Default.aspx?queryparsed=id:131634439URI

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  • Language:English

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  • Subject category:ref swepub-contenttype
  • Subject category:art swepub-publicationtype

Notes

  • Background and objective: We explored which clinical and biochemical variables predict conversion from clinically isolated syndrome (CIS) to clinically definite multiple sclerosis (CDMS) in a large international cohort. Methods: Thirty-three centres provided serum samples from 1047 CIS cases with at least two years' follow-up. Age, sex, clinical presentation, T2-hyperintense lesions, cerebrospinal fluid (CSF) oligoclonal bands (OCBs), CSF IgG index, CSF cell count, serum 25-hydroxyvitamin D3 (25-OH-D), cotinine and IgG titres against Epstein-Barr nuclear antigen 1 (EBNA-1) and cytomegalovirus were tested for association with risk of CDMS. Results: At median follow-up of 4.31 years, 623 CIS cases converted to CDMS. Predictors of conversion in multivariable analyses were OCB (HR = 2.18, 95% CI = 1.71-2.77, p < 0.001), number of T2 lesions (two to nine lesions vs 0/1 lesions: HR = 1.97, 95% CI = 1.52-2.55, p < 0.001; >9 lesions vs 0/1 lesions: HR = 2.74, 95% CI = 2.04-3.68, p < 0.001) and age at CIS (HR per year inversely increase = 0.98, 95% CI = 0.98-0.99, p < 0.001). Lower 25-OH-D levels were associated with CDMS in univariable analysis, but this was attenuated in the multivariable model. OCB positivity was associated with higher EBNA-1 IgG titres. Conclusions: We validated MRI lesion load, OCB and age at CIS as the strongest independent predictors of conversion to CDMS in this multicentre setting. A role for vitamin D is suggested but requires further investigation.

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  • Disanto, G. (author)
  • Dobson, R. (author)
  • Adiutori, R. (author)
  • Bianchi, L. (author)
  • Topping, J. (author)
  • Bestwick, J. P. (author)
  • Meier, U. C. (author)
  • Marta, M.Karolinska Institutet (author)
  • Dalla Costa, G. (author)
  • Runia, T. (author)
  • Evdoshenko, E. (author)
  • Lazareva, N. (author)
  • Thouvenot, E. (author)
  • Iaffaldano, P. (author)
  • Direnzo, V. (author)
  • Khademi, M. (author)
  • Piehl, F.Karolinska Institutet (author)
  • Comabella, M. (author)
  • Sombekke, M. (author)
  • Killestein, J. (author)
  • Hegen, H. (author)
  • Rauch, S. (author)
  • D'Alfonso, S. (author)
  • Alvarez-Cermeno, J. C. (author)
  • Kleinova, P. (author)
  • Horakova, D. (author)
  • Roesler, R. (author)
  • Lauda, F. (author)
  • Llufriu, S. (author)
  • Avsar, T. (author)
  • Uygunoglu, U. (author)
  • Altintas, A. (author)
  • Saip, S. (author)
  • Menge, T. (author)
  • Rajda, C. (author)
  • Bergamaschi, R. (author)
  • Moll, N. (author)
  • Khalil, M. (author)
  • Marignier, R. (author)
  • Dujmovic, I. (author)
  • Larsson, H. (author)
  • Malmeström, Clas,1965Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi,Institute of Neuroscience and Physiology(Swepub:gu)xmalcl (author)
  • Scarpini, E. (author)
  • Fenoglio, C. (author)
  • Wergeland, S. (author)
  • Laroni, A. (author)
  • Annibali, V. (author)
  • Romano, S. (author)
  • Martinez, A. D. (author)
  • Carra, A. (author)
  • Salvetti, M. (author)
  • Uccelli, A. (author)
  • Torkildsen, O.Karolinska Institutet (author)
  • Myhr, K. M. (author)
  • Galimberti, D. (author)
  • Rejdak, K. (author)
  • Lycke, Jan,1956Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi,Institute of Neuroscience and Physiology(Swepub:gu)xlycja (author)
  • Frederiksen, J. L. (author)
  • Drulovic, J. (author)
  • Confavreux, C. (author)
  • Brassat, D. (author)
  • Enzinger, C. (author)
  • Fuchs, S. (author)
  • Bosca, I. (author)
  • Pelletier, J. (author)
  • Picard, C. (author)
  • Colombo, E. (author)
  • Franciotta, D. (author)
  • Derfuss, T. (author)
  • Lindberg, R. L. P. (author)
  • Yaldizli, O. (author)
  • Vecsei, L. (author)
  • Kieseier, B. C. (author)
  • Hartung, H. P. (author)
  • Villoslada, P. (author)
  • Siva, A. (author)
  • Saiz, A. (author)
  • Tumani, H. (author)
  • Havrdova, E. (author)
  • Villar, L. M. (author)
  • Leone, M. (author)
  • Barizzone, N. (author)
  • Deisenhammer, F. (author)
  • Teunissen, C. (author)
  • Montalban, X. (author)
  • Tintore, M. (author)
  • Olsson, T. (author)
  • Trojano, M. (author)
  • Lehmann, S. (author)
  • Castelnovo, G. (author)
  • Lapin, S. (author)
  • Hintzen, R. (author)
  • Kappos, L. (author)
  • Furlan, R. (author)
  • Martinelli, V. (author)
  • Comi, G. (author)
  • Ramagopalan, S. V. (author)
  • Giovannoni, G. (author)
  • Karolinska InstitutetInstitutionen för neurovetenskap och fysiologi (creator_code:org_t)

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  • In:Multiple Sclerosis Journal: SAGE Publications21:8, s. 1013-10241352-45851477-0970

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By the author/editor
Kuhle, J.
Disanto, G.
Dobson, R.
Adiutori, R.
Bianchi, L.
Topping, J.
show more...
Bestwick, J. P.
Meier, U. C.
Marta, M.
Dalla Costa, G.
Runia, T.
Evdoshenko, E.
Lazareva, N.
Thouvenot, E.
Iaffaldano, P.
Direnzo, V.
Khademi, M.
Piehl, F.
Comabella, M.
Sombekke, M.
Killestein, J.
Hegen, H.
Rauch, S.
D'Alfonso, S.
Alvarez-Cermeno, ...
Kleinova, P.
Horakova, D.
Roesler, R.
Lauda, F.
Llufriu, S.
Avsar, T.
Uygunoglu, U.
Altintas, A.
Saip, S.
Menge, T.
Rajda, C.
Bergamaschi, R.
Moll, N.
Khalil, M.
Marignier, R.
Dujmovic, I.
Larsson, H.
Malmeström, Clas ...
Scarpini, E.
Fenoglio, C.
Wergeland, S.
Laroni, A.
Annibali, V.
Romano, S.
Martinez, A. D.
Carra, A.
Salvetti, M.
Uccelli, A.
Torkildsen, O.
Myhr, K. M.
Galimberti, D.
Rejdak, K.
Lycke, Jan, 1956
Frederiksen, J. ...
Drulovic, J.
Confavreux, C.
Brassat, D.
Enzinger, C.
Fuchs, S.
Bosca, I.
Pelletier, J.
Picard, C.
Colombo, E.
Franciotta, D.
Derfuss, T.
Lindberg, R. L. ...
Yaldizli, O.
Vecsei, L.
Kieseier, B. C.
Hartung, H. P.
Villoslada, P.
Siva, A.
Saiz, A.
Tumani, H.
Havrdova, E.
Villar, L. M.
Leone, M.
Barizzone, N.
Deisenhammer, F.
Teunissen, C.
Montalban, X.
Tintore, M.
Olsson, T.
Trojano, M.
Lehmann, S.
Castelnovo, G.
Lapin, S.
Hintzen, R.
Kappos, L.
Furlan, R.
Martinelli, V.
Comi, G.
Ramagopalan, S. ...
Giovannoni, G.
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About the subject
MEDICAL AND HEALTH SCIENCES
MEDICAL AND HEAL ...
and Basic Medicine
and Neurosciences
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Multiple Scleros ...
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University of Gothenburg
Karolinska Institutet

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