Sökning: onr:"swepub:oai:gup.ub.gu.se/220623" > Genetic Disruption ...
Fältnamn | Indikatorer | Metadata |
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000 | 06627naa a2200601 4500 | |
001 | oai:gup.ub.gu.se/220623 | |
003 | SwePub | |
008 | 240528s2015 | |||||||||||000 ||eng| | |
024 | 7 | a https://gup.ub.gu.se/publication/2206232 URI |
024 | 7 | a https://doi.org/10.2337/db15-00602 DOI |
040 | a (SwePub)gu | |
041 | a eng | |
042 | 9 SwePub | |
072 | 7 | a ref2 swepub-contenttype |
072 | 7 | a art2 swepub-publicationtype |
100 | 1 | a Amrutkar, Manoju Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för molekylär och klinisk medicin,Institute of Medicine, Department of Molecular and Clinical Medicine4 aut |
245 | 1 0 | a Genetic Disruption of Protein Kinase STK25 Ameliorates Metabolic Defects in a Diet-Induced Type 2 Diabetes Model |
264 | c 2015-04-06 | |
264 | 1 | b American Diabetes Association,c 2015 |
520 | a Understanding the molecular networks controlling ectopic lipid deposition, glucose tolerance, and insulin sensitivity is essential to identifying new pharmacological approaches to treat type 2 diabetes. We recently identified serine/threonine protein kinase 25 (STK25) as a negative regulator of glucose and insulin homeostasis based on observations in myoblasts with acute depletion of STK25 and in STK25-overexpressing transgenic mice. Here, we challenged Stk25 knockout mice and wild-type littermates with a high-fat diet and showed that STK25 deficiency suppressed development of hyperglycemia and hyperinsulinemia, improved systemic glucose tolerance, reduced hepatic gluconeogenesis, and increased insulin sensitivity. Stk25(-/-) mice were protected from diet-induced liver steatosis accompanied by decreased protein levels of acetyl-CoA carboxylase, a key regulator of both lipid oxidation and synthesis. Lipid accumulation in Stk25(-/-) skeletal muscle was reduced, and expression of enzymes controlling the muscle oxidative capacity (Cpt1, Acox1, Cs, Cycs, Ucp3) and glucose metabolism (Glut1, Glut4, Hk2) was increased. These data are consistent with our previous study of STK25 knockdown in myoblasts and reciprocal to the metabolic phenotype of Stk25 transgenic mice, reinforcing the validity of the results. The findings suggest that STK25 deficiency protects against the metabolic consequences of chronic exposure to dietary lipids and highlight the potential of STK25 antagonists for the treatment of type 2 diabetes. | |
650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Endokrinologi och diabetes0 (SwePub)302052 hsv//swe |
650 | 7 | a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Endocrinology and Diabetes0 (SwePub)302052 hsv//eng |
653 | a HEPATIC INSULIN-RESISTANCE | |
653 | a AMYLOID PRECURSOR PROTEIN | |
653 | a ACETYL-COA | |
653 | a CARBOXYLASE-1 | |
653 | a DOUBLECORTIN-LIKE-KINASE | |
653 | a FATTY-ACID OXIDATION | |
653 | a NEURONAL | |
653 | a MIGRATION | |
653 | a SKELETAL-MUSCLE | |
653 | a LIPIDOMIC ANALYSIS | |
653 | a CELL-DEATH | |
653 | a MICE | |
653 | a Endocrinology & Metabolism | |
700 | 1 | a Cansby, Emmelie,d 1984u Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för molekylär och klinisk medicin,Institute of Medicine, Department of Molecular and Clinical Medicine4 aut0 (Swepub:gu)xcanem |
700 | 1 | a Chursa, Urszulau Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för molekylär och klinisk medicin,Institute of Medicine, Department of Molecular and Clinical Medicine4 aut0 (Swepub:gu)xchuur |
700 | 1 | a Nuñez Durán, Estheru Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för molekylär och klinisk medicin,Institute of Medicine, Department of Molecular and Clinical Medicine4 aut |
700 | 1 | a Chanclón, Belénu Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för molekylär och klinisk medicin,Institute of Medicine, Department of Molecular and Clinical Medicine4 aut |
700 | 1 | a Ståhlman, Marcus,d 1975u Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för molekylär och klinisk medicin,Wallenberglaboratoriet,Institute of Medicine, Department of Molecular and Clinical Medicine,Wallenberg Laboratory4 aut0 (Swepub:gu)xstahm |
700 | 1 | a Fridén, Vincent,d 1975u Gothenburg University,Göteborgs universitet,Core Facilities, Centre for Physiology and Bio-Imaging,Core Facilities, Centre for Physiology and Bio-Imaging4 aut0 (Swepub:gu)xfrivi |
700 | 1 | a Mannerås Holm, Louise,d 1980u Gothenburg University,Göteborgs universitet,Wallenberglaboratoriet,Institutionen för medicin, avdelningen för molekylär och klinisk medicin,Wallenberg Laboratory,Institute of Medicine, Department of Molecular and Clinical Medicine4 aut0 (Swepub:gu)xmanlo |
700 | 1 | a Wickman, Anna,d 1969u Gothenburg University,Göteborgs universitet,Core Facilities, Centre for Physiology and Bio-Imaging,Core Facilities, Centre for Physiology and Bio-Imaging4 aut0 (Swepub:gu)xwican |
700 | 1 | a Smith, Ulf,d 1943u Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för molekylär och klinisk medicin,Institute of Medicine, Department of Molecular and Clinical Medicine4 aut0 (Swepub:gu)xsmiul |
700 | 1 | a Bäckhed, Fredrik,d 1973u Gothenburg University,Göteborgs universitet,Wallenberglaboratoriet,Institutionen för medicin, avdelningen för molekylär och klinisk medicin,Wallenberg Laboratory,Institute of Medicine, Department of Molecular and Clinical Medicine4 aut0 (Swepub:gu)xbafre |
700 | 1 | a Borén, Jan,d 1963u Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för molekylär och klinisk medicin,Wallenberglaboratoriet,Institute of Medicine, Department of Molecular and Clinical Medicine,Wallenberg Laboratory4 aut0 (Swepub:gu)xborej |
700 | 1 | a Howell, B. W.4 aut |
700 | 1 | a Mahlapuu, Margit,d 1972u Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för molekylär och klinisk medicin,Institute of Medicine, Department of Molecular and Clinical Medicine4 aut0 (Swepub:gu)xmahma |
710 | 2 | a Göteborgs universitetb Institutionen för medicin, avdelningen för molekylär och klinisk medicin4 org |
773 | 0 | t Diabetesd : American Diabetes Associationg 64:8, s. 2791-2804q 64:8<2791-2804x 0012-1797x 1939-327X |
856 | 4 | u https://diabetes.diabetesjournals.org/content/diabetes/64/8/2791.full.pdf |
856 | 4 8 | u https://gup.ub.gu.se/publication/220623 |
856 | 4 8 | u https://doi.org/10.2337/db15-0060 |
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