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The toxic effects o...
The toxic effects of microcystin-LR on mouse lungs and alveolar type II epithelial cells
- Article/chapterEnglish2016
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LIBRIS-ID:oai:gup.ub.gu.se/236990
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https://gup.ub.gu.se/publication/236990URI
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https://doi.org/10.1016/j.toxicon.2016.03.007DOI
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Subject category:ref swepub-contenttype
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Subject category:art swepub-publicationtype
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Objectives: Microcystin-leucine arginine (MC-LR) is produced by cyanobacteria and can accumulate in lungs through blood circulation. However, the effect of MC-LR on lung remains unclear. In this study, we investigated the chronic, low-dose effect of MC-LR on mouse lung tissues and the influence of MC-LR on mouse alveolar type II epithelial cells (ATII cells). Methods: MC-LR was orally administered to mice at 0, 1, 10, and 40 mu g/L for 6 consecutive months and mouse lungs were obtained for histopathological and immunoblot analysis. ATII cells were cultured in various concentrations of MC-LR (0, 0.5, 5, 50, 500 nmol/L) for indicated time and the cell viability and proteins change were tested. Results: Our study revealed that the chronic, low-dose MC-LR exposure induced alveolar collapse and lung cell apoptosis as well as the breach of cell junction integrity. Furthermore, following treatment with MC-LR, ATII cells could uptake MC-LR, resulting in apoptosis and disruption of cell junction integrity. Conclusions: These data support the toxic potential of low-dose MC-LR in rendering chronic injury to lung tissues.
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Gu, S.
(author)
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Yin, X. Q.
(author)
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Yuan, M. M.
(author)
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Xiang, ZouGothenburg University,Göteborgs universitet,Institutionen för biomedicin, avdelningen för mikrobiologi och immunologi,Institute of Biomedicine, Department of Microbiology and Immunology(Swepub:gu)xxiazo
(author)
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Li, Z. T.
(author)
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Cao, H. H.
(author)
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Meng, X. N.
(author)
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Hu, K. B.
(author)
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Han, X. D.
(author)
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Göteborgs universitetInstitutionen för biomedicin, avdelningen för mikrobiologi och immunologi
(creator_code:org_t)
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In:Toxicon: Elsevier BV115, s. 81-880041-0101
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Toxicon
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Wang, C.
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Gu, S.
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Yin, X. Q.
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Yuan, M. M.
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Xiang, Zou
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Li, Z. T.
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Cao, H. H.
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Meng, X. N.
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Hu, K. B.
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Han, X. D.
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- NATURAL SCIENCES
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NATURAL SCIENCES
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Toxicon
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University of Gothenburg