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  • Boeckxstaens, G. E. (author)

Phenotyping of subjects for large scale studies on patients with IBS

  • Article/chapterEnglish2016

Publisher, publication year, extent ...

  • 2016-06-19
  • Wiley,2016

Numbers

  • LIBRIS-ID:oai:gup.ub.gu.se/243623
  • https://gup.ub.gu.se/publication/243623URI
  • https://doi.org/10.1111/nmo.12886DOI

Supplementary language notes

  • Language:English

Part of subdatabase

Classification

  • Subject category:ref swepub-contenttype
  • Subject category:art swepub-publicationtype

Notes

  • Background: Irritable bowel syndrome (IBS) is a complex condition with multiple factors contributing to its aetiology and pathophysiology. Aetiologically these include genetics, life-time events and environment, and physiologically, changes in motility, central processing, visceral sensitivity, immunity, epithelial permeability and gastrointestinal microflora. Such complexity means there is currently no specific reliable biomarker for IBS, and thus IBS continues to be diagnosed and classified according to symptom based criteria, the Rome Criteria. Carefully phenotyping and characterisation of a ‘large’ pool of IBS patients across Europe and even the world however, might help identify sub-populations with accuracy and consistency. This will not only aid future research but improve tailoring of treatment and health care of IBS patients. Purpose: The aim of this position paper is to discuss the requirements necessary to standardize the process of selecting and phenotyping IBS patients and how to organise the collection and storage of patient information/samples in such a large multi-centre pan European/global study. We include information on general demographics, gastrointestinal symptom assessment, psychological factors, quality of life, physiological evaluation, genetic/epigenetic and microbiota analysis, biopsy/blood sampling, together with discussion on the organisational, ethical and language issues associated with implementing such a study. The proposed approach and documents selected to be used in such a study was the result of a thoughtful and thorough four-year dialogue amongst experts associated with the European COST action BM1106 GENIEUR (www.GENIEUR.eu). © 2016 John Wiley & Sons Ltd

Subject headings and genre

Added entries (persons, corporate bodies, meetings, titles ...)

  • Drug, V. (author)
  • Dumitrascu, D. (author)
  • Farmer, A. D. (author)
  • Hammer, J. (author)
  • Hausken, T. (author)
  • Niesler, B. (author)
  • Pohl, D. (author)
  • Pojskic, L. (author)
  • Polster, AnnikkaGothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för invärtesmedicin och klinisk nutrition,Institute of Medicine, Department of Internal Medicine and Clinical Nutrition(Swepub:gu)xpolan (author)
  • Simrén, Magnus,1966Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för invärtesmedicin och klinisk nutrition,Institute of Medicine, Department of Internal Medicine and Clinical Nutrition(Swepub:gu)xsimrm (author)
  • Goebel-Stengel, M. (author)
  • Van Oudenhove, L. (author)
  • Vassallo, M. (author)
  • Wensaas, K. A. (author)
  • Aziz, Q. (author)
  • Houghton, L. A. (author)
  • Göteborgs universitetInstitutionen för medicin, avdelningen för invärtesmedicin och klinisk nutrition (creator_code:org_t)

Related titles

  • In:Neurogastroenterology and Motility: Wiley28:8, s. 1134-11471350-19251365-2982

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