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FältnamnIndikatorerMetadata
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001oai:gup.ub.gu.se/244482
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008240528s2016 | |||||||||||000 ||eng|
009oai:lup.lub.lu.se:a1089904-0acf-4b54-b9aa-99471a04695c
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024a https://gup.ub.gu.se/publication/2444822 URI
024a https://doi.org/10.2337/db16-01992 DOI
024a https://lup.lub.lu.se/record/a1089904-0acf-4b54-b9aa-99471a04695c2 URI
024a https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-3112242 URI
040 a (SwePub)gud (SwePub)lud (SwePub)uu
041 a eng
042 9 SwePub
072 7a ref2 swepub-contenttype
072 7a art2 swepub-publicationtype
100a Walford, G. A.u Harvard University,Massachusetts Gen Hosp, Diabet Unit, Diabet Res Ctr, Boston, MA 02114 USA.;Massachusetts Gen Hosp, Ctr Human Genet Res, Boston, MA 02114 USA.;Harvard Med Sch, Dept Med, Boston, MA 02115 USA.4 aut
2451 0a Genome-wide association study of the modified stumvoll insulin sensitivity index identifies BCL2 and FAM19A2 as novel insulin sensitivity loci
264 c 2016-07-14
264 1b American Diabetes Association,c 2016
500 a Funding:This work was supported by National Institutes of Health grant DK099249 (to G.A.W.). Grant support was provided to cohorts. For METSIM, the study was funded by the Academy of Finland (grants 77299 and 124243). For Sorbs, the work was supported by grants from the German Research Council (DFG-SFB 1052, "Obesity mechanisms," A01, C01, B03, and SPP 1629 TO 718/2-1), the German Diabetes Association, and the Diabetes Hilfs-und Forschungsfonds Deutschland (DHFD). This work was further supported by the Federal Ministry of Education and Research (BMBF), Germany, FKZ (01EO1501, AD2-060E to P.K.), and by the Boehringer Ingelheim Foundation. For FHS, the study was supported by the National Heart, Lung, and Blood Institute (contract nos. N02-HL-6-4278 [supporting its contract with Affymetrix, Inc., for genotyping services], N01-HC-25195, HL084756, and HHSN268201500001I) and the National Institute of Diabetes and Digestive and Kidney Diseases (R01 DK078616 to J.D., U01-DK085526 to H.C. and J.D., 2R01 DK078616 and K24 DK080140 to J.M.). A portion of this research utilized the Linux Cluster for Genetic Analysis (LinGA-II) funded by the Robert Dawson Evans Endowment of the Department of Medicine at Boston University School of Medicine and Boston Medical Center. A.K.M. was supported by American Diabetes Association Research Foundation (grant 7-12-MN-02). For CHS, research was supported by National Heart, Lung, and Blood Institute contract nos. HHSN268201200036C, HHSN268200800007C, N01HC55222, N01HC85079, N01HC85080, N01HC85081, N01HC85082, N01HC85083, and N01HC85086 and grant nos. U01HL080295, HL105756, and HL120393, with additional contribution from the National Institute of Neurological Disorders and Stroke. Additional support was provided by R01AG023629 from the National Institute on Aging (NIA). For ULSAM, the project was supported by the Knut and Alice Wallenberg Foundation (Wallenberg Academy Fellow), the European Research Council (ERC Starting Grant), the Swedish Diabetes Foundation (grant 2013-024), the Swedish Research Council (grant 2012-1397), and the Swedish Heart-Lung Foundation (20120197). A.P.M. is a Wellcome Trust Senior Fellow in Basic Biomedical Science (grant WT098017 from the Nordic Center of Excellence in Disease Genetics). For LURIC, the study was supported by the 7th Framework Program (AtheroRemo, grant agreement no. 201668, and RiskyCAD, grant agreement no. 305739) of the European Union and by the INTERREG-IV-Oberrhein-Program (Project A28, Genetic mechanisms of cardiovascular diseases) with support from the European Regional Development Fund (ERDF) and the Wissenschaftsoffensive. M.E.K. and W.M. are supported by the German Federal Ministry of Education and Research as part of the Competence Cluster of Nutrition and Cardiovascular Health (nutriCARD). For Inter99, the study was financially supported by research grants from the Danish Research Council, the Danish Centre for Health Technology Assessment, Novo Nordisk, the Research Foundation of Copenhagen County, Ministry of Internal Affairs and Health of Denmark, the Danish Heart Foundation, the Danish Pharmaceutical Association, the Augustinus Foundation, the Ib Henriksen Foundation, the Becket Foundation, and the Danish Diabetes Association. For FUSION, the study was supported by the National Institute of Diabetes and Digestive and Kidney Diseases (DK093757, DK072193, DK062370) and the National Human Genome Research Institute (ZIA-HG000024). H.A.K. has received funding from the Academy of Finland (support for clinical research careers, grant no. 258753).Work on the Amish Studies was supported by National Institutes of Health awards K23GM102678 (from National Institute of General Medical Sciences) to J.P.L. and HL084756 (from National Heart, Lung, and Blood Institute) to J.R.O. The Botnia study has been financially supported by grants from the Sigrid Juselius Foundation, the Folkhalsan Research Foundation, the Nordic Center of Excellence in Disease Genetics, a European Union grant (EXGENESIS, GA FP6 2004-005272), the Signe and Ane Gyllenberg Foundation, the Swedish Cultural Foundation in Finland, the Finnish Diabetes Research Foundation, the Foundation for Life and Health in Finland, the Finnish Medical Society, the Paavo Nurmi Foundation, the Helsinki University Central Hospital Research Foundation, the Perklen Foundation, the Ollqvist Foundation, the Narpes Health Care Foundation, and the Ahokas Foundation. The DGI study was further supported by a Swedish Research Council Linne grant (2006-237) and by the Ministry of Education in Finland, the Municipal Health Care Center and Hospital in Jakobstad, and the Health Care Centers in Vasa, Narpes, and Korsholm. The Tubingen study was supported in part by a grant from the German Federal Ministry of Education and Research to the German Center for Diabetes Research (DZD e.V.). For the Ely Study, J.L., C. Lang, R.A.S., and N.J.W. acknowledge support from the Medical Research Council (MC_UU_12015/1). The Ely Study was funded by the Medical Research Council (MC_U106179471) and Diabetes UK. Genotyping in the Ely and Fenland studies was supported in part by a Medical Research Council-GlaxoSmithKline pilot program grant (G0701863). For the Birth Cohort 1936 and Inter99 studies, work was support by the Novo Nordisk Foundation Center for Basic Metabolic Research, an independent research center at the University of Copenhagen partially funded by an unrestricted donation from the Novo Nordisk Foundation (www.metabol.ku.dk). Work on the Pizarra study was support by Instituto de Salud Carlos III PI11/00880 and Instituto de Salud Carlos III PS09/02117. For Segovia, this work was supported by the Fondo Europeo para el Desarrollo Regional, Red de Centros RCMN (C03/08) grants FEDER 2FD 1997/2309, the Instituto de Salud Carlos III-RETIC RD06/0015/0012, Madrid, Spain (FIS 03/1618); CIBER in Diabetes and Associated Metabolic Disorders (Instituto de Salud Carlos III, Ministerio de Ciencia e Innovacion); and the Madrid Autonomous Community (MOIR S2010/BMD-2423), and by educational grants from Eli Lilly Lab, Spain; Bayer Pharmaceutical Co., Spain; and the Fundacion Mutua Madrilena 2008, Spain.De tre första författarna delar förstaförfattarskapet.De två sista författarna delar sistaförfattarskapet.
520 a Genome-wide association studies (GWAS) have found few common variants that influence fasting measures of insulin sensitivity. We hypothesized that a GWAS of an integrated assessment of fasting and dynamic measures of insulin sensitivity would detect novel common variants. We performed a GWAS of the modified Stumvoll Insulin Sensitivity Index (ISI) within the Meta-Analyses of Glucose and Insulin-Related Traits Consortium. Discovery for genetic association was performed in 16,753 individuals, and replication was attempted for the 23 most significant novel loci in 13,354 independent individuals. Association with ISI was tested in models adjusted for age, sex, and BMI and in a model analyzing the combined influence of the genotype effect adjusted for BMI and the interaction effect between the genotype and BMI on ISI (model 3). In model 3, three variants reached genome-wide significance: Rs13422522 (NYAP2; P = 8.87 × 10-11), rs12454712 (BCL2; P = 2.7 × 10-8), and rs10506418 (FAM19A2; P = 1.9 × 10-8). The association at NYAP2 was eliminated by conditioning on the known IRS1 insulin sensitivity locus; the BCL2 and FAM19A2 associations were independent of known cardiometabolic loci. In conclusion, we identified two novel loci and replicated known variants associated with insulin sensitivity. Further studies are needed to clarify the causal variant and function at the BCL2 and FAM19A2 loci. © 2016 by the American Diabetes Association.
650 7a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Endokrinologi och diabetes0 (SwePub)302052 hsv//swe
650 7a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Endocrinology and Diabetes0 (SwePub)302052 hsv//eng
650 7a MEDICIN OCH HÄLSOVETENSKAPx Medicinska och farmaceutiska grundvetenskaperx Medicinsk genetik0 (SwePub)301072 hsv//swe
650 7a MEDICAL AND HEALTH SCIENCESx Basic Medicinex Medical Genetics0 (SwePub)301072 hsv//eng
700a Gustafsson, Stefanu Uppsala universitet,Uppsala University,Institutionen för medicinska vetenskaper4 aut0 (Swepub:uu)stegu732
700a Rybin, D.u Boston University,Boston Univ, Sch Publ Hlth, Data Coordinating Ctr, Boston, MA USA.4 aut
700a Stancáková, A.u University of Eastern Finland,Univ Eastern Finland, Kuopio, Finland.;Kuopio Univ Hosp, Kuopio, Finland.4 aut
700a Chen, H.u Harvard University,Boston Univ, Sch Publ Hlth, Dept Biostat, Boston, MA USA.;Harvard TH Chan Sch Publ Hlth, Dept Biostat, Boston, MA USA.4 aut
700a Liu, C. T.u Boston University,Boston Univ, Sch Publ Hlth, Dept Biostat, Boston, MA USA.4 aut
700a Hong, J.u Boston University,Boston Univ, Sch Publ Hlth, Dept Biostat, Boston, MA USA.4 aut
700a Jensen, R. A.u University of Washington,Univ Washington, Cardiovasc Hlth Res Unit, Seattle, WA 98195 USA.;Univ Washington, Dept Med, Seattle, WA USA.4 aut
700a Rice, K.u University of Washington,Yeshiva University,Univ Washington, Dept Biostat, Seattle, WA 98195 USA.,Albert Einstein Coll Med, Dept Med, Bronx, NY 10467 USA.;Montefiore Med Ctr, 111 E 210th St, Bronx, NY 10467 USA.;Albert Einstein Coll Med, Dept Epidemiol & Populat Hlth, Bronx, NY 10467 USA.4 aut
700a Morris, A. P.u Wellcome Trust Centre for Human Genetics,Univ Liverpool, Dept Biostat, Liverpool, Merseyside, England.;Univ Oxford, Wellcome Trust Ctr Human Genet, Oxford, England.4 aut
700a Mägi, R.u University of Tartu,Univ Tartu, Estonian Genome Ctr, Tartu, Estonia.4 aut
700a Tönjes, A.u Leipzig University,Univ Leipzig, Dept Med, Leipzig, Germany.4 aut
700a Prokopenko, I.u University of Oxford,Univ Oxford, Wellcome Trust Ctr Human Genet, Oxford, England.;Imperial Coll London, Dept Genom Common Dis, London, England.;Univ Oxford, Oxford Ctr Diabet Endocrinol & Metab, Oxford, England.4 aut
700a Kleber, M. E.u Heidelberg University,Heidelberg Univ, Med Fac Mannheim, Dept Med 5, Heidelberg, Germany.4 aut
700a Delgado, G.u Heidelberg University,Heidelberg Univ, Med Fac Mannheim, Dept Med 5, Heidelberg, Germany.4 aut
700a Silbernagel, G.u Medical University of Graz,Med Univ Graz, Dept Internal Med, Div Angiol, Graz, Austria.4 aut
700a Jackson, A. U.u University of Michigan,Univ Michigan, Dept Biostat, Ann Arbor, MI 48109 USA.;Univ Michigan, Ctr Stat Genet, Ann Arbor, MI 48109 USA.4 aut
700a Appel, E. V.u University of Copenhagen,Univ Copenhagen, Fac Hlth & Med Sci, Ctr Basic Metab Res, Novo Nordisk Fdn, Copenhagen, Denmark.4 aut
700a Grarup, N.u University of Copenhagen,Univ Copenhagen, Fac Hlth & Med Sci, Ctr Basic Metab Res, Novo Nordisk Fdn, Copenhagen, Denmark.4 aut
700a Lewis, J. P.u University of Maryland,Univ Maryland, Sch Med, Div Endocrinol Diabet & Nutr, Baltimore, MD 21201 USA.;Univ Maryland, Sch Med, Program Personalized & Genom Med, Baltimore, MD 21201 USA.4 aut
700a Montasser, M. E.u University of Maryland,Univ Maryland, Sch Med, Div Endocrinol Diabet & Nutr, Baltimore, MD 21201 USA.;Univ Maryland, Sch Med, Program Personalized & Genom Med, Baltimore, MD 21201 USA.4 aut
700a Ladenvall, Claesu Uppsala universitet,Uppsala University,Lund University,Institutionen för immunologi, genetik och patologi,Science for Life Laboratory, SciLifeLab,Lund Univ, Ctr Diabet, Dept Clin Sci Diabet & Endocrinol, Malmo, Sweden4 aut0 (Swepub:uu)clala862
700a Staiger, H.u University of Tübingen,Univ Tubingen Hosp, Div Endocrinol & Diabetol Angiol Nephrol & Clin C, Dept Internal Med, Tubingen, Germany.;German Ctr Diabet Res DZD, Tubingen, Germany.;Univ Tubingen, Helmholtz Ctr Munich, Inst Diabet Res & Metab Dis, Tubingen, Germany.4 aut
700a Luan, J.u University of Cambridge,Hospital Regional de Málaga,Univ Cambridge, Sch Clin Med, MRC Epidemiol Unit, Cambridge, England.,Inst Invest Biomed Malaga IBIMA, Malaga, Spain.;Hosp Carlos Haya Malaga, Sequencing & Genotyping Platform, Malaga, Spain.4 aut
700a Frayling, T. M.u University of Exeter,Univ Exeter, Sch Med, Exeter, Devon, England.4 aut
700a Weedon, M. N.u University of Exeter,Univ Exeter, Sch Med, Exeter, Devon, England.4 aut
700a Xie, W.u University of Exeter,Univ Exeter, Sch Med, Exeter, Devon, England.4 aut
700a Morcillo, S.u Hospital Regional de Málaga,CIBER Pathophysiol Obes & Nutr, Madrid, Spain.;Hosp Reg Univ Malaga, Dept Endocrinol & Nutr, Malaga, Spain.4 aut
700a Martínez-Larrad, M. T.u Hospital Clinico San Carlos de Madrid,Hosp Clin San Carlos IdISSC, Spanish Biomed Res Ctr Diabet & Associated Metab, Inst Invest Sanitaria, Madrid, Spain.4 aut
700a Lind, Larsu Uppsala universitet,Uppsala University,University of Eastern Finland,Univ Washington, Cardiovasc Hlth Res Unit, Seattle, WA 98195 USA.;Univ Washington, Dept Biostat, Seattle, WA 98195 USA.,Kardiovaskulär epidemiologi,Univ N Carolina, Dept Genet, Chapel Hill, NC USA.4 aut0 (Swepub:uu)larslind
700a Chen, Y. D. I.u University of California, Los Angeles,Harbor UCLA Med Ctr, Dept Pediat, Inst Translat Genom & Populat Sci, Torrance, CA 90509 USA.;Harbor UCLA Med Ctr, Dept Med, LABioMed, Torrance, CA 90509 USA.4 aut
700a Corbaton-Anchuelo, A.u Hospital Clinico San Carlos de Madrid,Hosp Clin San Carlos IdISSC, Spanish Biomed Res Ctr Diabet & Associated Metab, Inst Invest Sanitaria, Madrid, Spain.4 aut
700a Færch, K.u Steno Diabetes Center Copenhagen,Steno Diabet Ctr, Gentofte, Denmark.4 aut
700a Gómez-Zumaquero, J. M.4 aut
700a Goodarzi, M. O.u Cedars-Sinai Medical Center,Cedars Sinai Med Ctr, Div Endocrinol Diabet & Metab, Los Angeles, CA 90048 USA.4 aut
700a Kizer, J. R.4 aut
700a Koistinen, H. A.u University of Helsinki,Natl Inst Hlth & Welf, Dept Hlth, Helsinki, Finland.;Minerva Fdn, Inst Med Res, Biomedicum 2U, Helsinki, Finland.;Univ Helsinki, Dept Med, Helsinki, Finland.;Univ Helsinki, Abdominal Ctr Endocrinol, Helsinki, Finland.;Univ Helsinki, Cent Hosp, Helsinki, Finland.4 aut
700a Leong, A.u Massachusetts General Hospital,Harvard Med Sch, Dept Med, Boston, MA 02115 USA.;Massachusetts Gen Hosp, Div Gen Internal Med, Boston, MA 02114 USA.4 aut
700a Lind, L.u University of North Carolina4 aut
700a Lindgren, C.u Harvard University,Univ Oxford, Wellcome Trust Ctr Human Genet, Oxford, England.;Broad Inst Massachusetts Inst Technol & Harvard U, Cambridge, MA USA.4 aut
700a Machicao, F.u University of Tübingen,German Ctr Diabet Res DZD, Tubingen, Germany.;Univ Tubingen, Helmholtz Ctr Munich, Inst Diabet Res & Metab Dis, Tubingen, Germany.4 aut
700a Manning, A. K.u Harvard University,Massachusetts Gen Hosp, Ctr Human Genet Res, Boston, MA 02114 USA.;Harvard Med Sch, Dept Med, Boston, MA 02115 USA.;Broad Inst Massachusetts Inst Technol & Harvard U, Cambridge, MA USA.4 aut
700a Martín-Núñez, G. M.u Hospitales Regional Universitario y Virgen de la Victoria de Málaga,Hosp Reg Univ & Virgen de la Victoria Malaga, Dept Endocrinol & Nutr, Malaga, Spain.4 aut
700a Rojo-Martínez, G.u CIBER Diabetes y Enfermedades Metabólicas Asociadas (CIBERDEM),Hosp Reg Univ Malaga, Dept Endocrinol & Nutr, Malaga, Spain.;Inst Invest Biomed Malaga IBIMA, Malaga, Spain.;CIBER Diabet & Enfermedades Metab Asociadas CIBER, Madrid, Spain.4 aut
700a Rotter, J. I.u University of California, Los Angeles,Harbor UCLA Med Ctr, Dept Pediat, Inst Translat Genom & Populat Sci, Torrance, CA 90509 USA.;Harbor UCLA Med Ctr, Dept Med, LABioMed, Torrance, CA 90509 USA.4 aut
700a Siscovick, D. S.u New York Academy of Medicine,Univ Washington, Cardiovasc Hlth Res Unit, Seattle, WA 98195 USA.;Univ Washington, Dept Med, Seattle, WA USA.;Univ Washington, Dept Epidemiol, Seattle, WA 98195 USA.;New York Acad Med, New York, NY USA.4 aut
700a Zmuda, J. M.u University of Pittsburgh,Univ Pittsburgh, Grad Sch Publ Hlth, Dept Epidemiol, Pittsburgh, PA USA.4 aut
700a Zhang, Z.u Icahn School of Medicine at Mount Sinai,Icahn Sch Med Mt Sinai, Dept Genet & Genom Sci, New York, NY 10029 USA.;Icahn Sch Med Mt Sinai, Icahn Inst Genom & Multiscale Biol, New York, NY 10029 USA.4 aut
700a Serrano-Rios, M.u Hospital Clinico San Carlos de Madrid,Hosp Clin San Carlos IdISSC, Spanish Biomed Res Ctr Diabet & Associated Metab, Inst Invest Sanitaria, Madrid, Spain.4 aut
700a Smith, Ulf,d 1943u University of Gothenburg,Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för molekylär och klinisk medicin,Institute of Medicine, Department of Molecular and Clinical Medicine,Univ Gothenburg, Sahlgrenska Acad, Dept Mol & Clin Med, Lundberg Lab Diabet Res, Gothenburg, Sweden.4 aut0 (Swepub:gu)xsmiul
700a Soriguer, F.u CIBER Diabetes y Enfermedades Metabólicas Asociadas (CIBERDEM),National Human Genome Research Institute,Hosp Reg Univ Malaga, Dept Endocrinol & Nutr, Malaga, Spain.;Inst Invest Biomed Malaga IBIMA, Malaga, Spain.;CIBER Diabet & Enfermedades Metab Asociadas CIBER, Madrid, Spain.,NHGRI, Med Genom & Metab Genet Branch, NIH, Bethesda, MD 20892 USA.4 aut
700a Hansen, T.u University of Copenhagen,Univ Copenhagen, Fac Hlth & Med Sci, Ctr Basic Metab Res, Novo Nordisk Fdn, Copenhagen, Denmark.4 aut
700a JØrgensen, T. J.u Research Center for Prevention and Health,Dasman Diabetes Institute,Univ Copenhagen, Fac Hlth & Med Sci, Dept Publ Hlth, Copenhagen, Denmark.;Aalborg Univ, Fac Med, Aalborg, Denmark.;Res Ctr Prevent & Hlth, Copenhagen, Denmark.,Natl Inst Hlth & Welf, Chron Dis Prevent Unit, Helsinki, Finland.;Danube Univ Krems, Ctr Vasc Prevent, Krems, Austria.;King Abdulaziz Univ, Diabet Res Grp, Jeddah, Saudi Arabia.;Dasman Diabet Inst, Dasman, Kuwait.4 aut
700a Linnenberg, A.u University of Copenhagen,Res Ctr Prevent & Hlth, Copenhagen, Denmark.;Rigshosp, Dept Clin Expt Res, Glostrup, Denmark.;Univ Copenhagen, Fac Hlth & Med Sci, Dept Clin Med, Copenhagen, Denmark.4 aut
700a Pedersen, O.u University of Copenhagen,Univ Copenhagen, Fac Hlth & Med Sci, Ctr Basic Metab Res, Novo Nordisk Fdn, Copenhagen, Denmark.4 aut
700a Walker, M.u University of Newcastle upon Tyne,Newcastle Univ, Inst Cellular Med, Newcastle Upon Tyne, Tyne & Wear, England.4 aut
700a Langenberg, C.u University of Cambridge,Univ Cambridge, Sch Clin Med, MRC Epidemiol Unit, Cambridge, England.4 aut
700a Scott, R. A.u University of Cambridge,Univ Cambridge, Sch Clin Med, MRC Epidemiol Unit, Cambridge, England.4 aut
700a Wareham, N. J.u University of Cambridge,Univ Cambridge, Sch Clin Med, MRC Epidemiol Unit, Cambridge, England.4 aut
700a Fritsche, A.u University of Tübingen,Univ Tubingen Hosp, Div Endocrinol & Diabetol Angiol Nephrol & Clin C, Dept Internal Med, Tubingen, Germany.;German Ctr Diabet Res DZD, Tubingen, Germany.;Univ Tubingen, Helmholtz Ctr Munich, Inst Diabet Res & Metab Dis, Tubingen, Germany.4 aut
700a Häring, H. U.u University of Tübingen,Univ Tubingen Hosp, Div Endocrinol & Diabetol Angiol Nephrol & Clin C, Dept Internal Med, Tubingen, Germany.;German Ctr Diabet Res DZD, Tubingen, Germany.;Univ Tubingen, Helmholtz Ctr Munich, Inst Diabet Res & Metab Dis, Tubingen, Germany.4 aut
700a Stefan, N.u University of Tübingen,Univ Tubingen Hosp, Div Endocrinol & Diabetol Angiol Nephrol & Clin C, Dept Internal Med, Tubingen, Germany.;German Ctr Diabet Res DZD, Tubingen, Germany.;Univ Tubingen, Helmholtz Ctr Munich, Inst Diabet Res & Metab Dis, Tubingen, Germany.4 aut
700a Groop, Leifu Lund University,Lunds universitet,Translationell muskelforskning,Forskargrupper vid Lunds universitet,Translational Muscle Research,Lund University Research Groups,University of Helsinki,Lund Univ, Ctr Diabet, Dept Clin Sci Diabet & Endocrinol, Malmo, Sweden.;Univ Helsinki, Finnish Inst Mol Med, Helsinki, Finland.4 aut0 (Swepub:lu)endo-lgr
700a O'Connell, J. R.u University of Maryland,Univ Maryland, Sch Med, Div Endocrinol Diabet & Nutr, Baltimore, MD 21201 USA.;Univ Maryland, Sch Med, Program Personalized & Genom Med, Baltimore, MD 21201 USA.4 aut
700a Boehnke, M.u University of Michigan,Harvard University,Univ Michigan, Dept Biostat, Ann Arbor, MI 48109 USA.;Univ Michigan, Ctr Stat Genet, Ann Arbor, MI 48109 USA.,Harvard Med Sch, Dept Med, Boston, MA 02115 USA.;Massachusetts Gen Hosp, Div Gen Internal Med, Boston, MA 02114 USA.;Broad Inst Massachusetts Inst Technol & Harvard U, Cambridge, MA USA.4 aut
700a Bergman, R. N.u Cedars-Sinai Medical Center,Cedars Sinai Med Ctr, Diabet & Obes Res Inst, Los Angeles, CA USA.4 aut
700a Collins, F. S.4 aut
700a Mohlke, K. L.4 aut
700a Tuomilehto, J.4 aut
700a März, W.u Synlab Services GmbH,Heidelberg Univ, Med Fac Mannheim, Dept Med 5, Heidelberg, Germany.;Med Univ Graz, Clin Inst Med & Chem Lab Diagnost, Graz, Austria.;Synlab Serv GmbH, Synlab Acad, Mannheim, Germany.;Synlab Serv GmbH, Synlab Acad, Augsburg, Germany.4 aut
700a Kovacs, P.u Leipzig University,Univ Leipzig, Integrated Res & Treatment IFB Ctr AdiposityDis, Leipzig, Germany.4 aut
700a Stumvoll, M.u Leipzig University,Univ Leipzig, Dept Med, Leipzig, Germany.4 aut
700a Psaty, B. M.u Group Health Cooperative,Univ Washington, Cardiovasc Hlth Res Unit, Seattle, WA 98195 USA.;Univ Washington, Dept Med, Seattle, WA USA.;Univ Washington, Epidemiol & Hlth Serv, Seattle, WA 98195 USA.;Grp Hlth Res Inst, Seattle, WA USA.;Grp Hlth Cooperat Puget Sound, Seattle, WA USA.4 aut
700a Kuusisto, J.u University of Eastern Finland,Kuopio Univ Hosp, Kuopio, Finland.;Univ Eastern Finland, Dept Med, Kuopio, Finland.4 aut
700a Laakso, M.u Kuopio Univ Hosp, Kuopio, Finland.;Univ Eastern Finland, Dept Med, Kuopio, Finland.4 aut
700a Meigs, J. B.4 aut
700a Dupuis, J.u Boston Univ, Sch Publ Hlth, Dept Biostat, Boston, MA USA.;NHLBI, Framingham Heart Study, Framingham, MA USA.4 aut
700a Ingelsson, Eriku Uppsala universitet,Molekylär epidemiologi,Science for Life Laboratory, SciLifeLab,Stanford Univ, Dept Med, Sch Med, Div Cardiovasc Med, Stanford, CA 94305 USA.4 aut0 (Swepub:uu)ering425
700a Florez, J. C.u Harvard University,Massachusetts Gen Hosp, Diabet Unit, Diabet Res Ctr, Boston, MA 02114 USA.;Massachusetts Gen Hosp, Ctr Human Genet Res, Boston, MA 02114 USA.;Harvard Med Sch, Dept Med, Boston, MA 02115 USA.4 aut
710a Harvard Universityb Massachusetts Gen Hosp, Diabet Unit, Diabet Res Ctr, Boston, MA 02114 USA.;Massachusetts Gen Hosp, Ctr Human Genet Res, Boston, MA 02114 USA.;Harvard Med Sch, Dept Med, Boston, MA 02115 USA.4 org
773t Diabetesd : American Diabetes Associationg 65:10, s. 3200-3211q 65:10<3200-3211x 0012-1797x 1939-327X
856u https://diabetes.diabetesjournals.org/content/diabetes/65/10/3200.full.pdf
856u http://dx.doi.org/10.2337/db16-0199y FULLTEXT
8564 8u https://gup.ub.gu.se/publication/244482
8564 8u https://doi.org/10.2337/db16-0199
8564 8u https://lup.lub.lu.se/record/a1089904-0acf-4b54-b9aa-99471a04695c
8564 8u https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-311224

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