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Fibronectin stimula...
Fibronectin stimulates transcription of the platelet-derived growth factor beta-receptor in cultured rat aortic smooth muscle cells.
- Artikel/kapitelEngelska1998
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LIBRIS-ID:oai:gup.ub.gu.se/249566
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https://gup.ub.gu.se/publication/249566URI
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https://doi.org/10.1006/bbrc.1998.9529DOI
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Fibronectin seems to play an important role in promoting the characteristic changes of vascular smooth muscle cells in diabetes mellitus including overexpression of the platelet-derived growth factor beta-receptor. To determine the regulatory mechanism of the beta-receptor by fibronectin, we have analyzed the effect of fibronectin on the expression of the beta-receptor in cultured rat aortic smooth muscle cells using the beta-receptor promoter/luciferase expression vector system. Fibronectin was found to stimulate the expression of the beta-receptor at the transcriptional level. Both a MEK1 inhibitor PD98059 and a tyrosine kinase inhibitor herbimycin A significantly inhibited the fibronectin-stimulated receptor transcription. Herbimycin A also completely inhibited the fibronectin-stimulated increase in tyrosine phosphorylation of focal adhesion kinase. These data suggest the involvement of the integrin-mediated mitogen-activated protein kinase pathway downstream of fibronectin stimulation in the activation process of the beta-receptor promoter.
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Yokote, K
(författare)
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Takemoto, M
(författare)
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Matsumoto, T
(författare)
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Ishisaki, A
(författare)
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Funa, Keiko,1949Gothenburg University,Göteborgs universitet,Institutionen för anatomi och cellbiologi,Institute of Anatomy and Cell Biology(Swepub:gu)xfunke
(författare)
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Saito, Y
(författare)
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Mori, S
(författare)
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Göteborgs universitetInstitutionen för anatomi och cellbiologi
(creator_code:org_t)
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Ingår i:Biochemical and biophysical research communications: Elsevier BV251:3, s. 677-800006-291X
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