Sökning: onr:"swepub:oai:gup.ub.gu.se/249615" > MraY-antibiotic com...
Fältnamn | Indikatorer | Metadata |
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000 | 02747naa a2200409 4500 | |
001 | oai:gup.ub.gu.se/249615 | |
003 | SwePub | |
008 | 240528s2017 | |||||||||||000 ||eng| | |
024 | 7 | a https://gup.ub.gu.se/publication/2496152 URI |
024 | 7 | a https://doi.org/10.1038/nchembio.22702 DOI |
040 | a (SwePub)gu | |
041 | a eng | |
042 | 9 SwePub | |
072 | 7 | a ref2 swepub-contenttype |
072 | 7 | a art2 swepub-publicationtype |
100 | 1 | a Hakulinen, Jonna K4 aut |
245 | 1 0 | a MraY-antibiotic complex reveals details of tunicamycin mode of action. |
264 | c 2017-01-09 | |
264 | 1 | b Springer Science and Business Media LLC,c 2017 |
520 | a The rapid increase of antibiotic resistance has created an urgent need to develop novel antimicrobial agents. Here we describe the crystal structure of the promising bacterial target phospho-N-acetylmuramoyl-pentapeptide translocase (MraY) in complex with the nucleoside antibiotic tunicamycin. The structure not only reveals the mode of action of several related natural-product antibiotics but also gives an indication on the binding mode of the MraY UDP-MurNAc-pentapeptide and undecaprenyl-phosphate substrates. | |
650 | 7 | a NATURVETENSKAPx Biologix Strukturbiologi0 (SwePub)106012 hsv//swe |
650 | 7 | a NATURAL SCIENCESx Biological Sciencesx Structural Biology0 (SwePub)106012 hsv//eng |
650 | 7 | a NATURVETENSKAPx Biologix Mikrobiologi0 (SwePub)106062 hsv//swe |
650 | 7 | a NATURAL SCIENCESx Biological Sciencesx Microbiology0 (SwePub)106062 hsv//eng |
650 | 7 | a NATURVETENSKAPx Biologix Biokemi och molekylärbiologi0 (SwePub)106022 hsv//swe |
650 | 7 | a NATURAL SCIENCESx Biological Sciencesx Biochemistry and Molecular Biology0 (SwePub)106022 hsv//eng |
700 | 1 | a Hering, Jennyu Gothenburg University,Göteborgs universitet,Institutionen för kemi och molekylärbiologi,Department of Chemistry and Molecular Biology4 aut0 (Swepub:gu)xherje |
700 | 1 | a Brändén, Gisela,d 1975u Gothenburg University,Göteborgs universitet,Institutionen för kemi och molekylärbiologi,Department of Chemistry and Molecular Biology4 aut0 (Swepub:gu)xbragi |
700 | 1 | a Chen, Hongming4 aut |
700 | 1 | a Snijder, Arjan4 aut |
700 | 1 | a Ek, Margareta4 aut |
700 | 1 | a Johansson, Patrik4 aut |
710 | 2 | a Göteborgs universitetb Institutionen för kemi och molekylärbiologi4 org |
773 | 0 | t Nature chemical biologyd : Springer Science and Business Media LLCg 13:3, s. 265-267q 13:3<265-267x 1552-4469x 1552-4450 |
856 | 4 | u https://zenodo.org/record/2527251/files/MraY-antibiotic%20complex%20reveals%20details%20of%20tunicamycin%20mode%20of%20action.pdf |
856 | 4 8 | u https://gup.ub.gu.se/publication/249615 |
856 | 4 8 | u https://doi.org/10.1038/nchembio.2270 |
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