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Gabapentin versus v...
Gabapentin versus vigabatrin as first add-on for patients with partial seizures that failed to respond to monotherapy: a randomized, double-blind, dose titration study. GREAT Study Investigators Group. Gabapentin in Refractory Epilepsy Add-on Treatment.
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Lindberger, M (författare)
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Alenius, M (författare)
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- Frisén, Lars, 1939 (författare)
- Gothenburg University,Göteborgs universitet,Institutionen för klinisk neurovetenskap, Sektionen för oftalmologi,Institute of Clinical Neurosciences, Section of Ophtalmology
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Johannessen, S I (författare)
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Larsson, S (författare)
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Malmgren, K (författare)
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- Tomson, T (författare)
- Karolinska Institutet
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(creator_code:org_t)
- Wiley, 2000
- 2000
- Engelska.
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Ingår i: Epilepsia. - : Wiley. - 0013-9580 .- 1528-1167. ; 41:10, s. 1289-95
- Relaterad länk:
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https://gup.ub.gu.se...
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http://kipublication...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- Our objective was to compare the efficacy and safety of gabapentin and vigabatrin as first-line add-on treatment in patients with partial epilepsy.This was a multicenter, double-blind, randomized dose titration study. After baseline assessment and randomization, the dose could be increased if seizures persisted and reduced if side effects occurred. Health-related quality of life was assessed at baseline and at the end of the study. By a protocol amendment post hoc, all randomized patients were offered a standardized perimetry examination at the end of the study. Improvement rate was the proportion of patients with a reduction of seizure frequency of at least 50% during an 8-week period without any adverse events causing withdrawal.One hundred two patients were randomized and analyzed on an intent-to-treat basis. The improvement rate was 48% in the gabapentin group and 56% in the vigabatrin group. The improvement rate, when per protocol criteria were fulfilled, was 57% in the gabapentin group and 59% in the vigabatrin group. The proportion of seizure-free patients was 31% in the gabapentin group and 39% in the vigabatrin group. There was no difference in quality-of-life scores between the groups. Perimetry after termination of the study on 64 patients showed abnormal results in 3 of 32 patients in the vigabatrin group.Approximately one third of the patients in both groups became seizure-free. Although no major differences were seen in terms of the improvement rate between the groups, equivalence between the two drugs was not found.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Neurologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Neurology (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Oftalmologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Ophthalmology (hsv//eng)
Nyckelord
- Acetates
- administration & dosage
- therapeutic use
- Adolescent
- Adult
- Aged
- Amines
- Anticonvulsants
- administration & dosage
- therapeutic use
- Child
- Cyclohexanecarboxylic Acids
- Double-Blind Method
- Drug Administration Schedule
- Drug Therapy
- Combination
- Epilepsies
- Partial
- drug therapy
- Female
- Humans
- Male
- Middle Aged
- Research Design
- Retrospective Studies
- Treatment Outcome
- Vigabatrin
- administration & dosage
- therapeutic use
- gamma-Aminobutyric Acid
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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