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Androgen Receptor S...
Androgen Receptor Signaling in Salivary Gland Cancer
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- Dalin, Martin, 1982 (författare)
- Gothenburg University,Göteborgs universitet,Institutionen för kliniska vetenskaper, Avdelningen för pediatrik,Institute of Clinical Sciences, Department of Pediatrics
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Watson, P. A. (författare)
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Ho, A. L. (författare)
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Morris, L. G. T. (författare)
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(creator_code:org_t)
- 2017-02-08
- 2017
- Engelska.
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Ingår i: Cancers. - : MDPI AG. - 2072-6694. ; 9:2
- Relaterad länk:
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https://www.mdpi.com...
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https://gup.ub.gu.se...
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https://doi.org/10.3...
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Abstract
Ämnesord
Stäng
- Salivary gland cancers comprise a small subset of human malignancies, and are classified into multiple subtypes that exhibit diverse histology, molecular biology and clinical presentation. Local disease is potentially curable with surgery, which may be combined with adjuvant radiotherapy. However, metastatic or unresectable tumors rarely respond to chemotherapy and carry a poorer prognosis. Recent molecular studies have shown evidence of androgen receptor signaling in several types of salivary gland cancer, mainly salivary duct carcinoma. Successful treatment with anti-androgen therapy in other androgen receptor-positive malignancies such as prostate and breast cancer has inspired researchers to investigate this treatment in salivary gland cancer as well. In this review, we describe the prevalence, biology, and therapeutic implications of androgen receptor signaling in salivary gland cancer.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
Nyckelord
- salivary gland cancer
- androgen receptor
- salivary duct carcinoma
- androgen-deprivation therapy (ADT)
- duct carcinoma
- prostate-cancer
- deprivation therapy
- molecular
- characterization
- mucoepidermoid carcinoma
- somatic mutations
- breast-cancer
- expression
- tumors
- apocrine
- Oncology
- winter jar
- 1991
- journal of histochemistry & cytochemistry
- v39
- p927
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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Cancers
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