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Ibuprofen and ketop...
Ibuprofen and ketoprofen potentiate UVA-induced cell death by a photosensitization process
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Bignon, E. (author)
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Marazzi, M. (author)
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Besancenot, V. (author)
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Gattuso, H. (author)
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Drouot, G. (author)
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Morell, C. (author)
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- Eriksson, Leif A, 1964 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för kemi och molekylärbiologi,Department of Chemistry and Molecular Biology
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Grandemange, S. (author)
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Dumont, E. (author)
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Monari, A. (author)
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(creator_code:org_t)
- 2017-08-21
- 2017
- English.
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In: Scientific Reports. - : Springer Science and Business Media LLC. - 2045-2322. ; 7
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https://www.nature.c...
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https://gup.ub.gu.se...
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https://doi.org/10.1...
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Abstract
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- Nonsteroidal 2-arylproprionic acids are widely used, over-the-counter, anti-inflammatory drugs. Photosensitivity is a commonly overlooked adverse effect of these drugs. Based on the combined use of cell viability assays and molecular modeling, we prove and rationalize the photochemical pathways triggering photosensitization for two drugs, ibuprofen and ketoprofen. As its parent compound benzophenone, ketoprofen produces singlet oxygen, upon triplet manifold population. However, ibuprofen and ketoprofen photodissociate and hence may generate two highly reactive radicals. The formation of metastable aggregates between the two drugs and B-DNA is also directly probed by molecular dynamics. Our approach characterizes the coupled influence of the drug's intrinsic photochemistry and the interaction pattern with DNA. The photosensitization activity of nonsteroidal 2-arylproprionic acids, being added to gels and creams for topical use, should be crucially analyzed and rationalized to enact the proper preventive measures.
Subject headings
- NATURVETENSKAP -- Biologi (hsv//swe)
- NATURAL SCIENCES -- Biological Sciences (hsv//eng)
- NATURVETENSKAP -- Kemi (hsv//swe)
- NATURAL SCIENCES -- Chemical Sciences (hsv//eng)
Keyword
- nonsteroidal antiinflammatory drugs
- singlet oxygen generation
- electron-transfer
- dna-damage
- photoexcited benzophenone
- force-field
- nile blue
- dynamics
- pain
- mechanism
- Science & Technology - Other Topics
Publication and Content Type
- ref (subject category)
- art (subject category)
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To the university's database
- By the author/editor
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Bignon, E.
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Marazzi, M.
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Besancenot, V.
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Gattuso, H.
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Drouot, G.
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Morell, C.
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show more...
-
Eriksson, Leif A ...
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Grandemange, S.
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Dumont, E.
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Monari, A.
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show less...
- About the subject
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- NATURAL SCIENCES
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NATURAL SCIENCES
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and Biological Scien ...
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- NATURAL SCIENCES
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NATURAL SCIENCES
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and Chemical Science ...
- Articles in the publication
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Scientific Repor ...
- By the university
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University of Gothenburg