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MAIT cells accumula...
MAIT cells accumulate in placental intervillous space and display a highly cytotoxic phenotype upon bacterial stimulation
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- Solders, M. (författare)
- Karolinska Institutet
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- Gorchs, L. (författare)
- Karolinska Institutet
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- Erkers, T. (författare)
- Karolinska Institutet
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- Lundell, Anna-Carin, 1976 (författare)
- Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för reumatologi och inflammationsforskning,Institute of Medicine, Department of Rheumatology and Inflammation Research
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- Nava, S. (författare)
- Karolinska Institutet
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- Gidlof, S. (författare)
- Karolinska Institutet
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Tiblad, E. (författare)
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- Magalhaes, I. (författare)
- Karolinska Institutet
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- Kaipe, H. (författare)
- Karolinska Institutet
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(creator_code:org_t)
- 2017-07-21
- 2017
- Engelska.
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Ingår i: Scientific Reports. - : Springer Science and Business Media LLC. - 2045-2322. ; 7
- Relaterad länk:
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https://www.nature.c...
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https://gup.ub.gu.se...
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https://doi.org/10.1...
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http://kipublication...
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Abstract
Ämnesord
Stäng
- During pregnancy, the maternal immune system must tolerate the developing foetus, and yet retain a potent antimicrobial response to prevent infections. Mucosal associated invariant T (MAIT) cells recognize microbial-derived vitamin B metabolites presented on the MR1 molecule, but their presence and function at the foetal-maternal interface is not known. We here isolated mononuclear cells from paired samples of peripheral blood (PB), intervillous blood (IVB), and decidua parietalis (DP) following uncomplicated term pregnancies. Interestingly, MAIT cells were highly enriched in IVB compared to PB and DP. The activation status of IVB MAIT cells was similar to that of PB MAIT cells, except for a lower expression of PD-1. Both IVB MAIT cells and conventional T cells were more dominated by an effector memory phenotype compared to PB MAIT cells and T cells. IVB MAIT cells also responded more vigorously with expression of IFN-gamma, granzyme B, and perforin in response to Escherichia coli stimulation compared to PB. MR1 was not expressed in syncytiotrophoblasts, but in placental villous and decidual macrophages. These data indicate that maternal MAIT cells accumulate in the intervillous space of the placenta and that they are highly armed to quickly respond if bacteria are encountered at the foetal-maternal interface.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine (hsv//eng)
Nyckelord
- invariant t-cells
- human term pregnancy
- peripheral-blood
- decidual
- tissue
- immune-system
- activation
- trophoblast
- leukocytes
- expression
- infection
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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