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An intra-neural mic...
An intra-neural microstimulation system for ultra-high field magnetic resonance imaging and magnetoencephalography
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Glover, P. M. (författare)
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- Watkins, Roger H., 1988 (författare)
- Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi,Institute of Neuroscience and Physiology
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O'Neill, G. C. (författare)
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- Ackerley, Rochelle, 1980 (författare)
- Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi,Institute of Neuroscience and Physiology
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Sanchez-Panchuelo, R. (författare)
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McGlone, F. (författare)
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Brookes, M. J. (författare)
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- Wessberg, Johan, 1962 (författare)
- Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för fysiologi,Institute of Neuroscience and Physiology, Department of Physiology
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Francis, S. T. (författare)
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(creator_code:org_t)
- Elsevier BV, 2017
- 2017
- Engelska.
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Ingår i: Journal of Neuroscience Methods. - : Elsevier BV. - 0165-0270. ; 290, s. 69-78
- Relaterad länk:
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https://doi.org/10.1...
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https://gup.ub.gu.se...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- Background: Intra-neural microstimulation (INMS) is a technique that allows the precise delivery of low-current electrical pulses into human peripheral nerves. Single unit INMS can be used to stimulate individual afferent nerve fibres during microneurography. Combining this with neuroimaging allows the unique monitoring of central nervous system activation in response to unitary, controlled tactile input, with functional magnetic resonance imaging (fMRI) providing exquisite spatial localisation of brain activity and magnetoencephalography (MEG) high temporal resolution. New method: INMS systems suitable for use within electrophysiology laboratories have been available for many years. We describe an INMS system specifically designed to provide compatibility with both ultra-high field (7 T) fMRI and MEG. Numerous technical and safety issues are addressed. The system is fully analogue, allowing for arbitrary frequency and amplitude INMS stimulation. Results: Unitary recordings obtained within both the MRI and MEG screened -room environments are comparable with those obtained in 'clean' electrophysiology recording environments. Single unit INMS (current <7 mu A, 200 mu s pulses) of individual mechanoreceptive afferents produces appropriate and robust responses during fMRI and MEG. Comparison with existing method(s): This custom-built MRI- and MEG-compatible stimulator overcomes issues with existing INMS approaches; it allows well-controlled switching between recording and stimulus mode, prevents electrical shocks because of long cable lengths, permits unlimited patterns of stimulation, and provides a system with improved work-flow and participant comfort. Conclusions: We demonstrate that the requirements for an INMS-integrated system, which can be used with both fMRI and MEG imaging systems, have been fully met. (C) 2017 The Author(s). Published by Elsevier B.V.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Fysiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Physiology (hsv//eng)
- TEKNIK OCH TEKNOLOGIER -- Medicinteknik -- Medicinsk laboratorie- och mätteknik (hsv//swe)
- ENGINEERING AND TECHNOLOGY -- Medical Engineering -- Medical Laboratory and Measurements Technologies (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Neurovetenskaper (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Neurosciences (hsv//eng)
Nyckelord
- Instrumentation
- Stimulus generation
- Low-noise amplifier
- Nerve stimulation
- human hand
- intraneural microstimulation
- somatosensory cortex
- sensations
- afferents
- responses
- units
- Biochemistry & Molecular Biology
- Neurosciences & Neurology
- arleston
- sc
- v16
- p1025
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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