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Grey and white matt...
Grey and white matter differences in Chronic Fatigue Syndrome – A voxel-based morphometry study
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Finkelmeyer, A. (författare)
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He, J. (författare)
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- Maclachlan, Laura (författare)
- Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för samhällsmedicin och folkhälsa, enheten för arbets-och miljömedicin,Institute of Medicine, Department of Public Health and Community Medicine, Section of Occupational and environmental medicine
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Watson, S. (författare)
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Gallagher, P. (författare)
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Newton, J. L. (författare)
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Blamire, A. M. (författare)
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(creator_code:org_t)
- Elsevier BV, 2018
- 2018
- Engelska.
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Ingår i: NeuroImage: Clinical. - : Elsevier BV. - 2213-1582. ; 17, s. 24-30
- Relaterad länk:
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https://doi.org/10.1...
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https://gup.ub.gu.se...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- Objective Investigate global and regional grey and white matter volumes in patients with Chronic Fatigue Syndrome (CFS) using magnetic resonance imaging (MRI) and recent voxel-based morphometry (VBM) methods. Methods Forty-two patients with CFS and thirty healthy volunteers were scanned on a 3-Tesla MRI scanner. Anatomical MRI scans were segmented, normalized and submitted to a VBM analysis using randomisation methods. Group differences were identified in overall segment volumes and voxel-wise in spatially normalized grey matter (GM) and white matter (WM) segments. Results Accounting for total intracranial volume, patients had larger GM volume and lower WM volume. The voxel-wise analysis showed increased GM volume in several structures including the amygdala and insula in the patient group. Reductions in WM volume in the patient group were seen primarily in the midbrain, pons and right temporal lobe. Conclusion Elevated GM volume in CFS is seen in areas related to processing of interoceptive signals and stress. Reduced WM volume in the patient group partially supports earlier findings of WM abnormalities in regions of the midbrain and brainstem. © 2017 The Author(s)
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Neurologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Neurology (hsv//eng)
Nyckelord
- Amygdala
- Chronic Fatigue Syndrome
- Insula
- Midbrain
- Voxel-based morphometry
- adult
- anterior commissure
- Article
- brain size
- capsula interna
- cerebrospinal fluid
- clinical article
- controlled study
- corpus callosum
- disease severity
- external capsule
- female
- gray matter
- hippocampus
- human
- male
- medial temporal lobe
- mesencephalon
- middle aged
- middle temporal gyrus
- nuclear magnetic resonance imaging
- operculum (brain)
- pons
- priority journal
- putamen
- pyramidal tract
- superior temporal gyrus
- symptom
- temporal gyrus
- temporal lobe
- voxel based morphometry
- white matter
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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