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Interaction between...
Interaction between chlorhexidine and fluoride in a mouthrinse solution-a 4-day and 6-week randomized clinical pilot study
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Villa, O. (författare)
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- Ramberg, Per, 1949 (författare)
- Gothenburg University,Göteborgs universitet,Institutionen för odontologi,Institute of Odontology
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Fukui, H. (författare)
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visa fler...
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- Emilson, Claes-Göran (författare)
- Gothenburg University,Göteborgs universitet,Institutionen för odontologi,Institute of Odontology
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Papanikolaou, G. (författare)
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Heijl, L. (författare)
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Birkhed, D. (författare)
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visa färre...
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(creator_code:org_t)
- 2017-10-14
- 2018
- Engelska.
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Ingår i: Clin Oral Investig. - : Springer Science and Business Media LLC. - 1432-6981. ; 22:3, s. 1439-1448
- Relaterad länk:
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https://gup.ub.gu.se...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- The aim of the present investigation was to study if there is a reduced clinical effect and fluoride retention of a mouthrinse solution containing both chlorhexidine (CHX) and sodium fluoride (NaF). Two clinical trials were designed as double-blind, randomized, cross-over studies. In study I, 16 healthy subjects were asked to rinse twice daily for 1 min during 4 days of no tooth brushing with four solutions: (1) 0.12% CHX + 0.2% NaF, (2) 0.2% NaF, (3) 0.12% CHX, and (4) placebo. In study II, another 16 healthy subjects rinsed with the same four solutions twice daily after tooth brushing during a 6-week period. Plaque formation, gingivitis, and microbiological samples from plaque and saliva, as well as fluoride retention, were analyzed. Both studies showed that both CHX + NaF and CHX mouthrinses had the same clinical effect with regards to plaque formation and microflora in plaque and saliva. Similarly, fluoride retention was not altered by the CHX + NaF mouthrinse compared to the NaF solution. The combination of CHX and NaF in a mouthrinse showed the same clinical effect as the CHX solution. The retention of fluoride in the oral cavity was not affected by the combination of NaF and CHX. A mouthrinse solution containing a mixture of CHX and NaF may be an interesting product for risk patients for caries and periodontal disease. However, this should be verified in further long-term clinical studies.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Odontologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Dentistry (hsv//eng)
Nyckelord
- Chlorhexidine
- Clinical trial
- Dental plaque
- Fluoride
- Gingivitis
- Microbiology
- Mouthwash
- novo plaque-formation
- streptococcus-mutans
- antimicrobial mouthrinses
- containing dentifrices
- acid production
- caries
- gingivitis
- retention
- sodium
- susceptibility
- Dentistry
- Oral Surgery & Medicine
- dermid as
- 1985
- caries research
- v19
- p64
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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