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Biochemical and beh...
Biochemical and behavioral evidence for an interaction between ethanol and calcium channel antagonists.
- Artikel/kapitelEngelska1988
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LIBRIS-ID:oai:gup.ub.gu.se/268808
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https://gup.ub.gu.se/publication/268808URI
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Ämneskategori:ref swepub-contenttype
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Ämneskategori:art swepub-publicationtype
Anmärkningar
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In the present series of experiments we have studied the effects of the dihydropyridine calcium channel antagonist nifedipine on ethanol-induced changes in behavior and dopamine (DA) release and metabolism. The locomotor-stimulatory effect of low doses of ethanol (2.5 g/kg) was antagonized by nifedipine, whereas ethanol-induced sedation observed after higher doses (4.5 g/kg) was potentiated. Biochemical studies indicated that ethanol enhanced the metabolism and release of DA in the striatum and the DA-rich limbic regions measured by post mortem analyses of DA-metabolites by HPLC with electrochemical detection and by in vivo voltammetry in anaesthetized rats, respectively. Pretreatment with nifedipine antagonized the stimulatory effects of ethanol on the DA-system. Nifedipine reduced the preference for ethanol, estimated by the relative intake of ethanol (6% v/v) and water in a free-choice situation, suggesting an influence of nifedipine not only on the stimulatory but also on the positive reinforcing effects of ethanol. The present results suggest that the locomotor-stimulatory and positive reinforcing effects of ethanol as well as its enhancing effect on dopaminergic activity may involve an enhancement of calcium mediated mechanisms.
Ämnesord och genrebeteckningar
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SAMHÄLLSVETENSKAP Psykologi hsv//swe
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SOCIAL SCIENCES Psychology hsv//eng
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Animals
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Calcium Channel Blockers
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pharmacology
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Dopamine
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metabolism
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Dose-Response Relationship
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Drug
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Drug Interactions
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Ethanol
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pharmacology
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Female
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Male
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Mice
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Motor Activity
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drug effects
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Nifedipine
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pharmacology
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Rats
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Rats
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Inbred Strains
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Time Factors
Biuppslag (personer, institutioner, konferenser, titlar ...)
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Fahlke, Claudia,1964Gothenburg University,Göteborgs universitet,Psykologiska institutionen,Department of Psychology(Swepub:gu)xfahcl
(författare)
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Hulthe, P
(författare)
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Hård, E
(författare)
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Johannessen, K
(författare)
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Snape, B
(författare)
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Svensson, L
(författare)
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Göteborgs universitetPsykologiska institutionen
(creator_code:org_t)
Sammanhörande titlar
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Ingår i:Journal of neural transmission74:3, s. 181-93
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