Sökning: onr:"swepub:oai:gup.ub.gu.se/272050" > Systemic cytokines ...
Fältnamn | Indikatorer | Metadata |
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000 | 04644naa a2200553 4500 | |
001 | oai:gup.ub.gu.se/272050 | |
003 | SwePub | |
008 | 240910s2018 | |||||||||||000 ||eng| | |
024 | 7 | a https://gup.ub.gu.se/publication/2720502 URI |
024 | 7 | a https://doi.org/10.1111/nmo.133782 DOI |
040 | a (SwePub)gu | |
041 | a eng | |
042 | 9 SwePub | |
072 | 7 | a ref2 swepub-contenttype |
072 | 7 | a art2 swepub-publicationtype |
100 | 1 | a Bennet, Seanu Gothenburg University,Göteborgs universitet,Institutionen för medicin,Institute of Medicine4 aut |
245 | 1 0 | a Systemic cytokines are elevated in a subset of patients with irritable bowel syndrome but largely unrelated to symptom characteristics |
264 | c 2018-05-24 | |
264 | 1 | b Wiley,c 2018 |
520 | a BackgroundSerum levels of pro-inflammatory cytokines tend to be increased in irritable bowel syndrome (IBS) patients, or subgroups thereof. Still, the link between cytokine levels and IBS symptoms is unclear. We aim to determine systemic cytokine levels in IBS patients and healthy subjects (HS), confirm the presence of a subset of patients with an increased immune activity and to establish if cytokines are linked to IBS symptoms and pathophysiological factors. MethodsSerum levels of interleukin (IL)-1, IL-6, IL-8, tumor necrosis factor (TNF), and IL-10 were measured. All subjects reported IBS symptoms using validated questionnaires and underwent colonic sensorimotor testing. Multivariate supervised orthogonal partial least squares-discriminant analysis (OPLS-DA) and unsupervised principal component analysis (PCA) and hierarchical cluster analysis (HCA) were implemented. Key ResultsIrritable bowel syndrome patients (n=246) had higher serum levels of IL-1, IL-6, IL-8, TNF, and IL-10 compared to HS (n=21); however, serum cytokine profiles could not discriminate patients from HS. Moreover, cytokine levels were not correlated with symptoms among patients. Supervised OPLS-DA identified 104 patients (40% of patients) and unsupervised HCA analysis identified 49 patients (20%) with an increased immune activity indicated by elevated levels of serum cytokines compared to HS and the other patients. However, irrespective of how patients with increased immune activity were identified they were symptomatically similar to patients with no indication of increased immune activity. Conclusions & InferencesSerum cytokines are elevated in IBS patients compared to HS. Immune activation characterizes a subset of patients, but modest associations between cytokine profile and symptoms suggest immune activity does not directly influence symptoms in IBS. | |
650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Gastroenterologi0 (SwePub)302132 hsv//swe |
650 | 7 | a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Gastroenterology and Hepatology0 (SwePub)302132 hsv//eng |
653 | a cytokines | |
653 | a IBS | |
653 | a symptom | |
653 | a functional gastrointestinal disorders | |
653 | a placebo-controlled trial | |
653 | a quality-of-life | |
653 | a immune activation | |
653 | a gut microbiota | |
653 | a mast-cells | |
653 | a ibs | |
653 | a validation | |
653 | a disease | |
653 | a questionnaire | |
653 | a Gastroenterology & Hepatology | |
653 | a Neurosciences & Neurology | |
700 | 1 | a Palsson, O.4 aut |
700 | 1 | a Whitehead, W. E.4 aut |
700 | 1 | a Barrow, D. A.4 aut |
700 | 1 | a Törnblom, Hans,d 1966u Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för invärtesmedicin och klinisk nutrition,Institute of Medicine, Department of Internal Medicine and Clinical Nutrition4 aut0 (Swepub:gu)xtornh |
700 | 1 | a Öhman, Lena,d 1967u Gothenburg University,Göteborgs universitet,Institutionen för biomedicin, avdelningen för mikrobiologi och immunologi,Institutionen för medicin, avdelningen för invärtesmedicin och klinisk nutrition,Institute of Biomedicine, Department of Microbiology and Immunology,Institute of Medicine, Department of Internal Medicine and Clinical Nutrition4 aut0 (Swepub:gu)xohmal |
700 | 1 | a Simrén, Magnus,d 1966u Gothenburg University,Göteborgs universitet,Institutionen för medicin,Institute of Medicine4 aut0 (Swepub:gu)xsimrm |
700 | 1 | a van Tilburg, M. A. L.4 aut |
710 | 2 | a Göteborgs universitetb Institutionen för medicin4 org |
773 | 0 | t Neurogastroenterology and Motilityd : Wileyg 30:10q 30:10x 1350-1925x 1365-2982 |
856 | 4 | u https://cdr.lib.unc.edu/downloads/pn89dd08t |
856 | 4 8 | u https://gup.ub.gu.se/publication/272050 |
856 | 4 8 | u https://doi.org/10.1111/nmo.13378 |
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