Baroreceptor-induced decrease in muscle blood flow upon propranolol administration.

Lisander, Björn,1940Gothenburg University,Göteborgs universitet,Fysiologiska institutionen,Department of Physiology (författare)

The acute effects of propranolol, 1 mg/kg i.v., were studied in chloralosed, vagotomized cats. The vascularly isolated but innervated calf muscles were perfused from another animal. In one group of experiments, the carotid baroreceptors were exposed to ambient arterial pressure. Here, propranolol caused a fall in heart rate and an increase in resistance of the isolated muscle bed. In other experiments, the carotid sinuses were perfused at a constant pressure. In these animals, no increase in muscle flow resistance was observed after the drug. It is concluded that the increase in total peripheral resistance, seen initially upon propranolol administration, may be reflexly induced via the baroreceptors.

MEDICIN OCH HÄLSOVETENSKAP Medicinska och farmaceutiska grundvetenskaper Fysiologi hsv//swe
MEDICAL AND HEALTH SCIENCES Basic Medicine Physiology hsv//eng
Animals
Cats
Clonidine
pharmacology
Female
Hemodynamics
drug effects
Hexamethonium Compounds
pharmacology
Hindlimb
blood supply
Male
Muscles
blood supply
Pressoreceptors
physiology
Propranolol
pharmacology
Regional Blood Flow
drug effects

Nilsson, Holger,1956Gothenburg University,Göteborgs universitet,Fysiologiska institutionen,Department of Physiology(Swepub:gu)xnilho (författare)
Göteborgs universitetFysiologiska institutionen (creator_code:org_t)

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