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Updating our defini...
Updating our definitions of Parkinson's disease for a molecular age
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Chen-Plotkin, A. S. (författare)
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- Zetterberg, Henrik, 1973 (författare)
- Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi,Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry
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(creator_code:org_t)
- 2018
- 2018
- Engelska.
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Ingår i: Journal of Parkinson's Disease. - 1877-7171. ; 8:s1
- Relaterad länk:
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https://gup.ub.gu.se...
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visa fler...
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https://doi.org/10.3...
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Abstract
Ämnesord
Stäng
- Clinical definitions of Parkinson's disease (PD) are over 200 years old, while neuropathological definitions-which are still the basis of how we define the disease now-are over 100 years old. We argue that for both clinical care and therapeutic development, these definitions need updating for the molecular age in which we live. We highlight specific instances in which genetic or biochemical biomarkers are increasingly used for clinical trial enrollment in the neurodegenerative diseases, suggesting that molecular definition(s) of PD are already emerging. We review candidate biomarkers for PD-related pathologies and highlight the need for further validation. © 2018 IOS Press and the authors. All rights reserved.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Neurovetenskaper (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Neurosciences (hsv//eng)
Nyckelord
- Alpha-synuclein
- Biomarkers
- Genetic subtypes
- Parkinson's disease
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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