Evaluation of in vivo wear of vitamin E-diffused highly crosslinked polyethylene at five years

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Galea, V. P. (author)

Evaluation of in vivo wear of vitamin E-diffused highly crosslinked polyethylene at five years

Article/chapterEnglish2018

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2018

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LIBRIS-ID:oai:gup.ub.gu.se/277926
https://gup.ub.gu.se/publication/277926URI
https://doi.org/10.1302/0301-620X.100B12.BJJ-2018-0371.R1DOI
http://kipublications.ki.se/Default.aspx?queryparsed=id:140306313URI

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Language:English

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Subject category:art swepub-publicationtype

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Aims The primary aim of this study was to compare the wear properties of vitamin E-diffused, highly crosslinked polyethylene (VEPE) and one formulation of moderately crosslinked and mechanically annealed ultra-high molecular weight polyethylene (ModXLPE) in patients five years after primary total hip arthroplasty (THA). The secondary aim was to assess the clinical results of patients treated with VEPE by evaluating patient-reported outcome measures (PROMs), radiological evidence of fixation, and the incidence of mechanical failure. Patients and Methods A total of 208 patients (221 THAs) from four international centres were recruited into a prospective study involving radiostereometric analysis (RSA) and the assessment of clinical outcomes. A total of 193 hips (87%) were reviewed at the five-year follow-up. Of these, 136 (70%) received VEPE (vs ModXLPE) liners and 68 (35%) received ceramic (vs metal) femoral heads. PROMs and radiographs were collected preoperatively and at one, two, and five years postoperatively. In addition, RSA images were collected to measure PE wear postoperatively and at one, two, and five years after surgery. Results We observed similar bedding in one year postoperatively and wear two years postoperatively between the two types of liner. However, there was significantly more penetration of the femoral head in the ModXLPE cohort compared with the VEPE cohort five years postoperatively (p < 0.001). The only variables independently predictive of increased wear were ModXLPE (vs VEPE) liner type (β = 0.22, p = 0.010) and metal (vs ceramic) femoral head (β = 0.21, p = 0.013). There was no association between increased wear and the development of radiolucency (p = 0.866) or PROMs. No patient had evidence of osteolysis. Conclusion Five years postoperatively, patients with VEPE (vs ModXLPE) and ceramic (vs metal) femoral heads had decreased wear. The rates of wear for both liners were very low and have not led to any osteolysis or implant failure due to aseptic loosening. ©2018 The British Editorial Society of Bone & Joint Surgery.

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MEDICIN OCH HÄLSOVETENSKAP Klinisk medicin Ortopedi hsv//swe
MEDICAL AND HEALTH SCIENCES Clinical Medicine Orthopaedics hsv//eng

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Connelly, J. W. (author)
Shareghi, BitaGothenburg University,Göteborgs universitet,Institutionen för kliniska vetenskaper, Avdelningen för ortopedi,Institute of Clinical Sciences, Department of Orthopaedics(Swepub:gu)xshabi (author)
Kärrholm, Johan,1951Gothenburg University,Göteborgs universitet,Institutionen för kliniska vetenskaper, Avdelningen för ortopedi,Institute of Clinical Sciences, Department of Orthopaedics(Swepub:gu)xkarjo (author)
Sköldenberg, O.Karolinska Institutet (author)
Salemyr, M. (author)
Laursen, M. B. (author)
Muratoglu, O. (author)
Bragdon, C. (author)
Malchau, H. (author)
Göteborgs universitetInstitutionen för kliniska vetenskaper, Avdelningen för ortopedi (creator_code:org_t)

Related titles

In:Bone and Joint Journal100B100-B:12, s. 1592-15992049-4394
In:The bone & joint journal100B100-B:12, s. 1592-15992049-4408

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By the author/editor: Galea, V. P.; Connelly, J. W.; Shareghi, Bita; Kärrholm, Johan, ...; Sköldenberg, O.; Salemyr, M.; show more...; Laursen, M. B.; Muratoglu, O.; Bragdon, C.; Malchau, H.; show less...

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MEDICAL AND HEALTH SCIENCES: MEDICAL AND HEAL ...; and Clinical Medicin ...; and Orthopaedics

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By the university: University of Gothenburg; Karolinska Institutet

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