Sökning: onr:"swepub:oai:gup.ub.gu.se/279904" >
The HLA-B-21 dimorp...
The HLA-B-21 dimorphism impacts on NK cell education and clinical outcome of immunotherapy in acute myeloid leukemia
-
- Hallner, Alexander, 1990 (författare)
- Gothenburg University,Göteborgs universitet,Sahlgrenska Cancer Center
-
- Bernson, Elin, 1987 (författare)
- Gothenburg University,Göteborgs universitet,Sahlgrenska Cancer Center
-
- Hussein, Brwa Ali, 1984 (författare)
- Gothenburg University,Göteborgs universitet,Sahlgrenska Cancer Center
-
visa fler...
-
- Sander, Frida Ewald (författare)
- Gothenburg University,Göteborgs universitet,Sahlgrenska Cancer Center
-
- Brune, Mats, 1950 (författare)
- Gothenburg University,Göteborgs universitet,Institutionen för biomedicin,Institute of Biomedicine
-
- Aurelius, Johan, 1980 (författare)
- Gothenburg University,Göteborgs universitet,Sahlgrenska Cancer Center
-
- Martner, Anna, 1979 (författare)
- Gothenburg University,Göteborgs universitet,Sahlgrenska Cancer Center
-
- Hellstrand, Kristoffer, 1956 (författare)
- Gothenburg University,Göteborgs universitet,Sahlgrenska Cancer Center
-
- Bergh Thorén, Fredrik, 1976 (författare)
- Gothenburg University,Göteborgs universitet,Sahlgrenska Cancer Center
-
visa färre...
-
(creator_code:org_t)
- American Society of Hematology, 2019
- 2019
- Engelska.
-
Ingår i: Blood. - : American Society of Hematology. - 0006-4971 .- 1528-0020. ; 133:13, s. 1479-1488
- Relaterad länk:
-
https://ashpublicati...
-
visa fler...
-
https://gup.ub.gu.se...
-
https://doi.org/10.1...
-
visa färre...
Abstract
Ämnesord
Stäng
- Natural killer (NK) cell function is regulated by inhibitory receptors, such as the family of killer immunoglobulin-like receptors (KIRs) and the NKG2A/CD94 heterodimer. These receptors recognize cognate HLA class I molecules on potential target cells, and recent studies imply that an HLA-B dimorphism at position -21 in the gene segment encoding the leader peptide dictates whether NK cell regulation primarily relies on the KIRs or the NKG2A/CD94 receptor. The impact of this HLA-B dimorphism on NK cell-mediated destruction of leukemic cells or on the course of leukemia is largely unknown. In a first part of this study, we compared functions of NK cells in subjects carrying HLA-B -21Mor 21T using interleukin-2 (IL-2)-activated NK cells and leukemic cells from patients with acute myeloid leukemia (AML). Subjects carrying HLA-B -21M harbored better-educated NKG2A1 NK cells and displayed superior capacity to degranulate lytic granules against KIR ligandmatched primary leukemic blasts. Second, we aimed to define the potential impact of HLA-B -21 variation on the course of AML in a phase 4 trial in which patients received IL-2based immunotherapy. In keeping with the hypothesis that 21M may be associated with improved NK cell functionality, we observed superior leukemia-free survival and overall survival in -21M patients than in -21T patients during IL-2based immunotherapy. We propose that genetic variation at HLA-B -21 may determine the antileukemic efficacy of activated NK cells and the clinical benefit of NK cell-activating immunotherapy.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Hematologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Hematology (hsv//eng)
Nyckelord
- mhc class-i
- natural-killer-cells
- hla-c expression
- inhibitory
- receptors
- activation
- relapse
- association
- cd94/nkg2a
- molecules
- infection
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
Hitta via bibliotek
-
Blood
(Sök värdpublikationen i LIBRIS)
Till lärosätets databas
- Av författaren/redakt...
-
Hallner, Alexand ...
-
Bernson, Elin, 1 ...
-
Hussein, Brwa Al ...
-
Sander, Frida Ew ...
-
Brune, Mats, 195 ...
-
Aurelius, Johan, ...
-
visa fler...
-
Martner, Anna, 1 ...
-
Hellstrand, Kris ...
-
Bergh Thorén, Fr ...
-
visa färre...
- Om ämnet
-
- MEDICIN OCH HÄLSOVETENSKAP
-
MEDICIN OCH HÄLS ...
-
och Klinisk medicin
-
och Hematologi
- Artiklar i publikationen
-
Blood
- Av lärosätet
-
Göteborgs universitet