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Dyslipidemia in ret...
Dyslipidemia in retinal metabolic disorders
- Article/chapterEnglish2019
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Numbers
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LIBRIS-ID:oai:gup.ub.gu.se/284967
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https://gup.ub.gu.se/publication/284967URI
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https://doi.org/10.15252/emmm.201910473DOI
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Subject category:ref swepub-contenttype
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Subject category:art swepub-publicationtype
Notes
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The light-sensitive photoreceptors in the retina are extremely metabolically demanding and have the highest density of mitochondria of any cell in the body. Both physiological and pathological retinal vascular growth and regression are controlled by photoreceptor energy demands. It is critical to understand the energy demands of photoreceptors and fuel sources supplying them to understand neurovascular diseases. Retinas are very rich in lipids, which are continuously recycled as lipid-rich photoreceptor outer segments are shed and reformed and dietary intake of lipids modulates retinal lipid composition. Lipids (as well as glucose) are fuel substrates for photoreceptor mitochondria. Dyslipidemia contributes to the development and progression of retinal dysfunction in many eye diseases. Here, we review photoreceptor energy demands with a focus on lipid metabolism in retinal neurovascular disorders.
Subject headings and genre
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MEDICIN OCH HÄLSOVETENSKAP Klinisk medicin hsv//swe
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MEDICAL AND HEALTH SCIENCES Clinical Medicine hsv//eng
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dyslipidemia
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FGF21
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photoreceptor
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retinal metabolism
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beta-oxidation
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polyunsaturated fatty-acids
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bevacizumab avastin therapy
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genome-wide
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association
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macular degeneration
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diabetic-retinopathy
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beta-oxidation
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choroidal neovascularization
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cerebrovascular accidents
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retinitis-pigmentosa
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photoreceptor cells
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Research & Experimental Medicine
Added entries (persons, corporate bodies, meetings, titles ...)
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Chen, C. T.
(author)
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Cagnone, G.
(author)
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Heckel, E.
(author)
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Sun, Y.
(author)
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Cakir, B.
(author)
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Tomita, Y.
(author)
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Huang, S.
(author)
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Li, Q.
(author)
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Britton, W.
(author)
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Cho, S. S.
(author)
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Kern, T. S.
(author)
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Hellström, Ann,1959Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi,Institute of Neuroscience and Physiology(Swepub:gu)xheann
(author)
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Joyal, J. S.
(author)
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Smith, L. E. H.
(author)
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Göteborgs universitetInstitutionen för neurovetenskap och fysiologi
(creator_code:org_t)
Related titles
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In:Embo Molecular Medicine: EMBO11:101757-46761757-4684
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- By the author/editor
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Fu, Z. J.
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Chen, C. T.
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Cagnone, G.
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Heckel, E.
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Sun, Y.
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Cakir, B.
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show more...
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Tomita, Y.
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Huang, S.
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Li, Q.
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Britton, W.
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Cho, S. S.
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Kern, T. S.
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Hellström, Ann, ...
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Joyal, J. S.
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Smith, L. E. H.
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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Embo Molecular M ...
- By the university
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University of Gothenburg