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Does the antisecret...
Does the antisecretory peptide AF-16 reduce lung oedema in experimental ARDS?
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- Barrueta Tenhunen, Annelie (författare)
- Uppsala universitet,Hedenstiernalaboratoriet
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- Massaro, Fabrizia (författare)
- Uppsala universitet,Hedenstiernalaboratoriet,Anthea Hosp, GVM Care & Res, Cardiac Anesthesia & Intens Care, Bari, Italy
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- Hansson, Hans-Arne, 1939 (författare)
- Gothenburg University,Göteborgs universitet,Institutionen för biomedicin,Institute of Biomedicine,Univ Gothenburg, Inst Biomed, Gothenburg, Sweden
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- Feinstein, R. (författare)
- Natl Vet Inst, Dept Pathol & Wildlife Dis, Uppsala, Sweden
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- Larsson, Anders (författare)
- Uppsala universitet,Klinisk kemi,Hedenstiernalaboratoriet
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- Perchiazzi, Gaetano (författare)
- Uppsala universitet,Hedenstiernalaboratoriet
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(creator_code:org_t)
- 2019-11-08
- 2019
- Engelska.
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Ingår i: Upsala Journal of Medical Sciences. - : Uppsala Medical Society. - 0300-9734 .- 2000-1967. ; 124:4, s. 246-253
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https://doi.org/10.1...
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https://gup.ub.gu.se...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- Background: Acute respiratory distress syndrome (ARDS) is an acute inflammatory condition with pulmonary capillary leakage and lung oedema formation. There is currently no pharmacologic treatment for the condition. The antisecretory peptide AF-16 reduces oedema in experimental traumatic brain injury. In this study, we tested AF-16 in an experimental porcine model of ARDS. Methods: Under surgical anaesthesia 12 piglets were subjected to lung lavage followed by 2 hours of injurious ventilation. Every hour for 4 hours, measurements of extravascular lung water (EVLW), mechanics of the respiratory system, and hemodynamics were obtained. Results: There was a statistically significant (p = 0.006, two-way ANOVA) reduction of EVLW in the AF-16 group compared with controls. However, this was not mirrored in any improvement in the wet-to-dry ratio of lung tissue samples, histology, inflammatory markers, lung mechanics, or gas exchange. Conclusions: This pilot study suggests that AF-16 might improve oedema resolution as indicated by a reduction in EVLW in experimental ARDS.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Anestesi och intensivvård (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Anesthesiology and Intensive Care (hsv//eng)
Nyckelord
- AF-16 antisecretory factor
- ARDS
- extravascular lung water
- pulmonary
- oedema
- acute respiratory-distress
- permeability
- stress
- strain
- AF-16 antisecretory factor
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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