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Haemodynamic effect...
Haemodynamic effects of loud noise in hypertensive patients treated with combined beta-adrenoceptor blockade and precapillary vasodilatation.
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- Eggertsen, Robert, 1948 (författare)
- Gothenburg University,Göteborgs universitet,Medicinska institutionen,Department medicine
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- Andrén, Lennart, 1946 (författare)
- Gothenburg University,Göteborgs universitet,Medicinska institutionen,Department medicine
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- Hansson, Lennart (författare)
- Gothenburg University,Göteborgs universitet,Medicinska institutionen,Department medicine
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(creator_code:org_t)
- 1984-07
- 1984
- Engelska.
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Ingår i: European heart journal. - : Oxford University Press (OUP). - 0195-668X .- 1522-9645. ; 5:7, s. 556-60
- Relaterad länk:
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https://gup.ub.gu.se...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- The effects of acute exposure to noise on central and regional (calf and forearm) haemodynamics were studied during placebo therapy and during combined nonselective beta-adrenoceptor blockade and precapillary vasodilatation in 9 patients with essential hypertension. On placebo therapy a loud noise (105 dBA for 10 min) caused a significant increase in diastolic and mean arterial pressure due to vasoconstriction. There was also a significant increase of vascular resistance in the calf. After combined precapillary vasodilatation and non-selective beta-adrenoceptor blockade, the increase in blood pressure during stimulation with noise was not prevented. Thus, systolic as well as diastolic and mean arterial pressures increased significantly. This indicates a temporary resetting of the baroreceptors, allowing a higher level of blood pressure during stimulation with noise. Such a resetting would involve the central nervous system pathways of the baroreflex and this would explain why the peripherally active therapeutic principle--precapillary vasodilatation and beta-adrenoceptor blockade--was unable to inhibit the blood pressure response induced by noise.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Allmänmedicin (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- General Practice (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine (hsv//eng)
Nyckelord
- Adult
- Female
- Forearm
- blood supply
- Hemodynamics
- drug effects
- Humans
- Hypertension
- drug therapy
- physiopathology
- Leg
- blood supply
- Male
- Middle Aged
- Noise
- adverse effects
- Pressoreceptors
- physiopathology
- Pyridazines
- pharmacology
- Stress
- Physiological
- physiopathology
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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