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Moderate- to high i...
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Andersson, Sofia E M,1979Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för reumatologi och inflammationsforskning,Institute of Medicine, Department of Rheumatology and Inflammation Research,Univ Gothenburg, Sahlgrenska Acad, Dept Rheumatol & Inflammat Res, Inst Med, Box 480, S-40530 Gothenburg, Sweden.
(author)
Moderate- to high intensity aerobic and resistance exercise reduces peripheral blood regulatory cell populations in older adults with rheumatoid arthritis
- Article/chapterEnglish2020
Publisher, publication year, extent ...
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2020-05-16
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Springer Science and Business Media LLC,2020
Numbers
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LIBRIS-ID:oai:gup.ub.gu.se/293968
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https://gup.ub.gu.se/publication/293968URI
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https://doi.org/10.1186/s12979-020-00184-yDOI
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https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-414306URI
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Subject category:ref swepub-contenttype
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Subject category:art swepub-publicationtype
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Objective Exercise can improve immune health and is beneficial for physical function in patients with rheumatoid arthritis (RA), but the immunological mechanisms are largely unknown. We evaluated the effect of moderate- to high intensity exercise with person-centred guidance on cells of the immune system, with focus on regulatory cell populations, in older adults with RA. Methods Older adults (>= 65 years) with RA were randomized to either 20-weeks of moderate - to high intensity aerobic and resistance exercise (n = 24) or to an active control group performing home-based exercise of light intensity (n = 25). Aerobic capacity, muscle strength, DAS28 and CRP were evaluated. Blood samples were collected at baseline and after 20 weeks. The frequency of immune cells defined as adaptive regulatory populations, CD4 + Foxp3 + CD25 + CD127- T regulatory cells (Tregs) and CD19 + CD24hiCD38hi B regulatory cells (Bregs) as well as HLA-DR-/lowCD33 + CD11b + myeloid derived suppressor cells (MDSCs), were assessed using flow cytometry. Results After 20 weeks of moderate- to high intensity exercise, aerobic capacity and muscle strength were significantly improved but there were no significant changes in Disease Activity Score 28 (DAS28) or CRP. The frequency of Tregs and Bregs decreased significantly in the intervention group, but not in the active control group. The exercise intervention had no effect on MDSCs. The reduction in regulatory T cells in the intervention group was most pronounced in the female patients. Conclusion Moderate- to high intensity exercise in older adults with RA led to a decreased proportion of Tregs and Bregs, but that was not associated with increased disease activity or increased inflammation.
Subject headings and genre
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Lange, ElviraGothenburg University,Göteborgs universitet,Centrum för personcentrerad vård vid Göteborgs universitet (GPCC),University of Gothenburg Centre for person-centred care (GPCC),Univ Gothenburg, Ctr Person Ctr Care, Gothenburg, Sweden.;Univ Gothenburg, Sahlgrenska Acad, Inst Neurosci & Physiol, Dept Hlth & Rehabil, Gothenburg, Sweden.(Swepub:gu)xlaelv
(author)
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Kucharski, DanielGothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för reumatologi och inflammationsforskning,Institute of Medicine, Department of Rheumatology and Inflammation Research,Univ Gothenburg, Sahlgrenska Acad, Dept Rheumatol & Inflammat Res, Inst Med, Box 480, S-40530 Gothenburg, Sweden.
(author)
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Svedlund, SaraGothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för molekylär och klinisk medicin,Institute of Medicine, Department of Molecular and Clinical Medicine,Univ Gothenburg, Sahlgrenska Acad, Inst Med, Dept Mol & Clin Med, Gothenburg, Sweden.(Swepub:gu)xsveds
(author)
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Önnheim, KarinGothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för reumatologi och inflammationsforskning,Institute of Medicine, Department of Rheumatology and Inflammation Research,Univ Gothenburg, Sahlgrenska Acad, Dept Rheumatol & Inflammat Res, Inst Med, Box 480, S-40530 Gothenburg, Sweden.(Swepub:gu)xgrank
(author)
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Bergquist, MariaUppsala universitet,Klinisk fysiologi(Swepub:uu)marbe919
(author)
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Josefsson, Elisabet,1966Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för reumatologi och inflammationsforskning,Institute of Medicine, Department of Rheumatology and Inflammation Research,Univ Gothenburg, Sahlgrenska Acad, Dept Rheumatol & Inflammat Res, Inst Med, Box 480, S-40530 Gothenburg, Sweden.(Swepub:gu)xjosel
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Lord, J. M.Univ Birmingham, MRC ARUK Ctr Musculoskeletal Ageing Res, Inst Inflammat & Ageing, Birmingham, W Midlands, England.
(author)
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Mårtensson, Inga-Lill,1957Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för reumatologi och inflammationsforskning,Institute of Medicine, Department of Rheumatology and Inflammation Research,Univ Gothenburg, Sahlgrenska Acad, Dept Rheumatol & Inflammat Res, Inst Med, Box 480, S-40530 Gothenburg, Sweden.(Swepub:gu)xmalil
(author)
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Mannerkorpi, Kaisa,1955Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för reumatologi och inflammationsforskning,Institute of Medicine, Department of Rheumatology and Inflammation Research,Univ Gothenburg, Ctr Person Ctr Care, Gothenburg, Sweden.;Univ Gothenburg, Sahlgrenska Acad, Inst Neurosci & Physiol, Dept Hlth & Rehabil, Gothenburg, Sweden.(Swepub:gu)xmannk
(author)
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Gjertsson, Inger,1962Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för reumatologi och inflammationsforskning,Institute of Medicine, Department of Rheumatology and Inflammation Research,Univ Gothenburg, Sahlgrenska Acad, Dept Rheumatol & Inflammat Res, Inst Med, Box 480, S-40530 Gothenburg, Sweden.;Univ Gothenburg, Ctr Person Ctr Care, Gothenburg, Sweden.(Swepub:gu)xgjein
(author)
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Göteborgs universitetInstitutionen för medicin, avdelningen för reumatologi och inflammationsforskning
(creator_code:org_t)
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In:Immunity & Ageing: Springer Science and Business Media LLC17:11742-4933
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