Sökning: onr:"swepub:oai:gup.ub.gu.se/296151" > Reference intervals...
Fältnamn | Indikatorer | Metadata |
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000 | 08427naa a2200997 4500 | |
001 | oai:gup.ub.gu.se/296151 | |
003 | SwePub | |
008 | 240528s2020 | |||||||||||000 ||eng| | |
009 | oai:DiVA.org:umu-180275 | |
009 | oai:DiVA.org:liu-174306 | |
009 | oai:DiVA.org:uu-441103 | |
009 | oai:prod.swepub.kib.ki.se:146151326 | |
009 | oai:lup.lub.lu.se:bbee6383-6f24-4ded-b244-64435614964d | |
024 | 7 | a https://gup.ub.gu.se/publication/2961512 URI |
024 | 7 | a https://doi.org/10.1530/EJE-19-08722 DOI |
024 | 7 | a https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-1802752 URI |
024 | 7 | a https://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-1743062 URI |
024 | 7 | a https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-4411032 URI |
024 | 7 | a http://kipublications.ki.se/Default.aspx?queryparsed=id:1461513262 URI |
024 | 7 | a https://lup.lub.lu.se/record/bbee6383-6f24-4ded-b244-64435614964d2 URI |
040 | a (SwePub)gud (SwePub)umud (SwePub)liud (SwePub)uud (SwePub)kid (SwePub)lu | |
041 | a eng | |
042 | 9 SwePub | |
072 | 7 | a ref2 swepub-contenttype |
072 | 7 | a art2 swepub-publicationtype |
100 | 1 | a Bäcklund, Nilsu Umeå University,Umeå universitet,Avdelningen för medicin,Department of Public Health and Clinical Medicine, Umeå University, Umeå, Sweden,Umeå Univ, Dept Publ Hlth & Clin Med, Umeå, Sweden4 aut0 (Swepub:umu)niba0024 |
245 | 1 0 | a Reference intervals of salivary cortisol and cortisone and their diagnostic accuracy in Cushing's syndrome |
264 | 1 | b Bioscientifica,c 2020 |
500 | a This study was supported by a donation to Umeå University for research on pituitary disease. | |
520 | a Objective: The challenge of diagnosing Cushing's syndrome (CS) calls for high precision biochemical screening. This study aimed to establish robust reference intervals for, and compare the diagnostic accuracy of, salivary cortisol and cortisone in late-night samples and after a low-dose (1 mg) dexamethasone suppression test (DST). Design and methods: Saliva samples were collected at 08:00 and 23:00 h, and at 08:00 h, after a DST, from 22 patients with CS and from 155 adult reference subjects. We also collected samples at 20:00 and 22:00 h from 78 of the reference subjects. Salivary cortisol and cortisone were analysed with liquid chromatography-tandem mass spectrometry. The reference intervals were calculated as the 2.5th and 97.5th percentiles of the reference population measurements. Diagnostic accuracies of different tests were compared, based on areas under the receiver-operating characteristic curves. Results: The upper reference limits of salivary cortisol and cortisone at 23:00 h were 3.6 nmol/L and 13.5 nmol/L, respectively. Using these reference limits, CS was detected with a sensitivity (95% CI) of 90% (70-99%) and specificity of 96% (91-98%) for cortisol, and a 100% (84-100%) sensitivity and 95% (90-98%) specificity for cortisone. After DST, cortisol and cortisone upper reference limits were 0.79 nmol/L and 3.5 nmol/L, respectively. CS was detected with 95% (75-100%) sensitivity and 96% (92-99%) specificity with cortisol, and 100% (83-100%) sensitivity and 94% (89-97%) specificity with cortisone. No differences in salivary cortisol or cortisone levels were found between samples collected at 22:00 and 23:00 h. Conclusion: Salivary cortisol and cortisone in late-night samples and after DST showed high accuracy for diagnosing CS, salivary cortisone being slightly, but significantly better. © 2020 European Society of Endocrinology Printed in Great Britain. | |
650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Endokrinologi och diabetes0 (SwePub)302052 hsv//swe |
650 | 7 | a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Endocrinology and Diabetes0 (SwePub)302052 hsv//eng |
650 | 7 | a NATURVETENSKAPx Kemix Analytisk kemi0 (SwePub)104012 hsv//swe |
650 | 7 | a NATURAL SCIENCESx Chemical Sciencesx Analytical Chemistry0 (SwePub)104012 hsv//eng |
650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Annan medicin och hälsovetenskapx Gerontologi, medicinsk/hälsovetenskaplig inriktning0 (SwePub)305022 hsv//swe |
650 | 7 | a MEDICAL AND HEALTH SCIENCESx Other Medical and Health Sciencesx Gerontology, specialising in Medical and Health Sciences0 (SwePub)305022 hsv//eng |
653 | a cortisone | |
653 | a dexamethasone | |
653 | a hydrocortisone | |
653 | a adult | |
653 | a aged | |
653 | a area under the curve | |
653 | a chemistry | |
653 | a circadian rhythm | |
653 | a Cushing syndrome | |
653 | a female | |
653 | a human | |
653 | a male | |
653 | a mass screening | |
653 | a middle aged | |
653 | a procedures | |
653 | a receiver operating characteristic | |
653 | a reference value | |
653 | a saliva | |
653 | a sensitivity and specificity | |
653 | a tandem mass spectrometry | |
653 | a time factor | |
653 | a very elderly | |
653 | a young adult | |
653 | a Aged | |
653 | a 80 and over | |
653 | a Area Under Curve | |
653 | a Humans | |
653 | a Reference Values | |
653 | a ROC Curve | |
653 | a Time Factors | |
700 | 1 | a Brattsand, Göranu Umeå University,Umeå universitet,Klinisk kemi,Department of Medical Biosciences, Clinical Chemistry, Umeå University, Umeå, Sweden,Umeå Univ, Dept Med Biosci, Clin Chem, Umeå, Sweden4 aut0 (Swepub:umu)gobr0001 |
700 | 1 | a Israelsson, Marlenu Umeå University,Umeå universitet,Klinisk kemi,Department of Medical Biosciences, Clinical Chemistry, Umeå University, Umeå, Sweden,Umeå Univ, Dept Med Biosci, Clin Chem, Umeå, Sweden4 aut0 (Swepub:umu)mais0016 |
700 | 1 | a Ragnarsson, Oskar,d 1971u Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för invärtesmedicin och klinisk nutrition,Institute of Medicine, Department of Internal Medicine and Clinical Nutrition,Department of Internal Medicine and Clinical Nutrition, Institute of Medicine at Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden; Department of Endocrinology, Sahlgrenska University Hospital, Gothenburg, Sweden,Univ Gothenburg, Inst Med, Dept Internal Med & Clin Nutr, Sahlgrenska Acad, Gothenburg, Sweden; Sahlgrens Univ Hosp, Dept Endocrinol, Gothenburg, Sweden4 aut0 (Swepub:gu)xragos |
700 | 1 | a Burman, Piau Lund University,Lunds universitet,Translationell muskelforskning,Forskargrupper vid Lunds universitet,Translational Muscle Research,Lund University Research Groups,Skåne University Hospital4 aut0 (Swepub:lu)med-bap |
700 | 1 | a Edén Engström, Brittu Uppsala University,Uppsala universitet,Endokrinologi och mineralmetabolism4 aut0 (Swepub:uu)brittee |
700 | 1 | a Høybye, C.u Karolinska Institutet,Karolinska University Hospital4 aut |
700 | 1 | a Berinder, K.u Karolinska Institutet,Karolinska University Hospital4 aut |
700 | 1 | a Wahlberg, Jeanette,d 1969-u Linköping University,Linköpings universitet,Avdelningen för diagnostik och specialistmedicin,Medicinska fakulteten,Region Östergötland, Endokrinmedicinska kliniken,Linköping Univ, Dept Med & Hlth Sci, Dept Endocrinol, Linköping, Sweden4 aut0 (Swepub:liu)jeawa98 |
700 | 1 | a Olsson, Tommyu Umeå University,Umeå universitet,Avdelningen för medicin,Department of Public Health and Clinical Medicine, Umeå University, Umeå, Sweden,Umeå Univ, Dept Publ Hlth & Clin Med, Umeå, Sweden4 aut0 (Swepub:umu)tool0003 |
700 | 1 | a Dahlqvist, Peru Umeå University,Umeå universitet,Avdelningen för medicin,Department of Public Health and Clinical Medicine, Umeå University, Umeå, Sweden,Umeå Univ, Dept Publ Hlth & Clin Med, Umeå, Sweden4 aut0 (Swepub:umu)perdat96 |
710 | 2 | a Umeå universitetb Avdelningen för medicin4 org |
773 | 0 | t European Journal of Endocrinologyd : Bioscientificag 182:6, s. 569-582q 182:6<569-582x 0804-4643x 1479-683X |
856 | 4 | u http://dx.doi.org/10.1530/EJE-19-0872y FULLTEXT |
856 | 4 8 | u https://gup.ub.gu.se/publication/296151 |
856 | 4 8 | u https://doi.org/10.1530/EJE-19-0872 |
856 | 4 8 | u https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-180275 |
856 | 4 8 | u https://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-174306 |
856 | 4 8 | u https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-441103 |
856 | 4 8 | u http://kipublications.ki.se/Default.aspx?queryparsed=id:146151326 |
856 | 4 8 | u https://lup.lub.lu.se/record/bbee6383-6f24-4ded-b244-64435614964d |
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