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Androgens in men st...
Androgens in men study (AIMS): Protocol for meta-analyses of individual participant data investigating associations of androgens with health outcomes in men
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- Yeap, B. B. (författare)
- University of Western Australia, Crawley
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- Marriott, R. J. (författare)
- University of Western Australia, Crawley
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- Adams, R. J. (författare)
- Flinders University
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- Antonio, L. (författare)
- Catholic University of Leuven
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- Ballantyne, C. M. (författare)
- Baylor College of Medicine
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- Bhasin, S. (författare)
- Harvard Medical School
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- Cawthon, P. M. (författare)
- California Pacific Medical Center
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- Couper, D. J. (författare)
- University of North Carolina
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- Dobs, A. S. (författare)
- Johns Hopkins University
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- Flicker, L. (författare)
- University of Western Australia, Crawley
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- Karlsson, Magnus (författare)
- Lund University,Lunds universitet,Ortopedi - klinisk och molekylär osteoporosforskning,Forskargrupper vid Lunds universitet,Orthopedics - Clinical and Molecular Osteoporosis Research,Lund University Research Groups
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- Martin, S. A. (författare)
- University of Adelaide
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- Matsumoto, A. M. (författare)
- VA Puget Sound Health Care System,Washington University School of Medicine
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- Mellström, Dan, 1945 (författare)
- Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för invärtesmedicin och klinisk nutrition,Centre for Bone and Arthritis Research,Institute of Medicine, Department of Internal Medicine and Clinical Nutrition,Sahlgrenska Academy
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- Norman, P. E. (författare)
- University of Western Australia, Crawley
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- Ohlsson, Claes, 1965 (författare)
- Gothenburg University,Göteborgs universitet,Centre for Bone and Arthritis Research,Institutionen för medicin, avdelningen för invärtesmedicin och klinisk nutrition,Institute of Medicine, Department of Internal Medicine and Clinical Nutrition,Sahlgrenska Academy
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- Orwoll, E. S. (författare)
- Oregon Health & Science University
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- O'Neill, T. W. (författare)
- University of Manchester,Manchester University NHS Foundation Trust
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- Shores, M. M. (författare)
- Washington University School of Medicine,VA Puget Sound Health Care System
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- Travison, T. G. (författare)
- Beth Israel Deaconess Medical Center,Harvard Medical School
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- Vanderschueren, D. (författare)
- Catholic University of Leuven
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- Wittert, G. A. (författare)
- University of Adelaide
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- Wu, F. C. W. (författare)
- University of Manchester
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- Murray, K. (författare)
- University of Western Australia, Crawley
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(creator_code:org_t)
- 2020-05-11
- 2020
- Engelska.
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Ingår i: BMJ Open. - : BMJ. - 2044-6055. ; 10:5
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https://bmjopen.bmj....
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http://dx.doi.org/10... (free)
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https://gup.ub.gu.se...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- Introduction This study aims to clarify the role(s) of endogenous sex hormones to influence health outcomes in men, specifically to define the associations of plasma testosterone with incidence of cardiovascular events, cancer, dementia and mortality risk, and to identify factors predicting testosterone concentrations. Data will be accrued from at least three Australian, two European and four North American population-based cohorts involving approximately 20 000 men. Methods and analysis Eligible studies include prospective cohort studies with baseline testosterone concentrations measured using mass spectrometry and 5 years of follow-up data on incident cardiovascular events, mortality, cancer diagnoses or deaths, new-onset dementia or decline in cognitive function recorded. Data for men, who were not taking androgens or drugs suppressing testosterone production, metabolism or action; and had no prior orchidectomy, are eligible. Systematic literature searches were conducted from 14 June 2019 to 31 December 2019, with no date range set for searches. Aggregate level data will be sought where individual participant data (IPD) are not available. One-stage IPD random-effects meta-analyses will be performed, using linear mixed models, generalised linear mixed models and either stratified or frailty-augmented Cox regression models. Heterogeneity in estimates from different studies will be quantified and bias investigated using funnel plots. Effect size estimates will be presented in forest plots and non-negligible heterogeneity and bias investigated using subgroup or meta-regression analyses. Ethics and dissemination Ethics approvals obtained for each of the participating cohorts state that participants have consented to have their data collected and used for research purposes. The Androgens In Men Study has been assessed as exempt from ethics review by the Human Ethics office at the University of Western Australia (file reference number RA/4/20/5014). Each of the component studies had obtained ethics approvals; please refer to respective component studies for details. Research findings will be disseminated to the scientific and broader community via the publication of four research articles, with each involving a separate set of IPD meta-analyses (articles will investigate different, distinct outcomes), at scientific conferences and meetings of relevant professional societies. Collaborating cohort studies will disseminate findings to study participants and local communities. PROSPERO registration number CRD42019139668. © Author(s) (or their employer(s)) 2020. Re-use permitted under CC BY. Published by BMJ.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Endokrinologi och diabetes (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Endocrinology and Diabetes (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Hälsovetenskap -- Folkhälsovetenskap, global hälsa, socialmedicin och epidemiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Health Sciences -- Public Health, Global Health, Social Medicine and Epidemiology (hsv//eng)
Nyckelord
- epidemiology
- general endocrinology
- sex steroids & HRT
- androgen
- androstanolone
- estradiol
- luteinizing hormone
- sex hormone binding globulin
- testosterone
- Article
- clinical outcome
- clinical protocol
- cognitive defect
- dementia
- disease association
- follow up
- frailty
- human
- malignant neoplasm
- mass spectrometry
- men's health
- meta analysis
- reference value
- systematic review
- testosterone metabolism
- testosterone synthesis
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
Hitta via bibliotek
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BMJ Open
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Till lärosätets databas
- Av författaren/redakt...
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Yeap, B. B.
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Marriott, R. J.
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Adams, R. J.
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Antonio, L.
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Ballantyne, C. M ...
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Bhasin, S.
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visa fler...
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Cawthon, P. M.
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Couper, D. J.
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Dobs, A. S.
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Flicker, L.
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Karlsson, Magnus
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Martin, S. A.
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Matsumoto, A. M.
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Mellström, Dan, ...
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Norman, P. E.
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Ohlsson, Claes, ...
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Orwoll, E. S.
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O'Neill, T. W.
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Shores, M. M.
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Travison, T. G.
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Vanderschueren, ...
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Wittert, G. A.
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Wu, F. C. W.
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Murray, K.
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- Om ämnet
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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och Klinisk medicin
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och Endokrinologi oc ...
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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och Hälsovetenskap
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och Folkhälsovetensk ...
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BMJ Open
- Av lärosätet
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Göteborgs universitet
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Lunds universitet